Fed-batch production of (S)-flurbiprofen in lipase-catalyzed dispersed aqueous phase reaction system induced by succinyl β-cyclodextrin and its extractive purification

Journal of Molecular Catalysis B: Enzymatic

Volumn 37, Issue 1-6, 2005, Pages 109-111

  Shin, Gab Sang ^a   Lee, Kwang Woo ^a   Lee, Yong Hyun ^a  

^a Kyungpook National University   (South Korea)

Author keywords

(R,S) Flurbiprofen ethyl ester; (S) Flurbiprofen; Extractive purification; Fed batch; Inclusion complex; Lipase; Succinyl cyclodextrin

Indexed keywords

CATALYSIS; ENZYME KINETICS; ESTERS; INCLUSIONS; PURIFICATION; REACTION KINETICS;

(R,S)-FLURBIPROVEN ETHYL ESTERS; (S)-FLURBIPROFEN; EXTRACTIVE PURIFICATION; FED-BATCH; INCLUSION COMPLEX; LIPASE;

ENZYMES;

2 PROPANOL; ACETIC ACID ETHYL ESTER; BETA CYCLODEXTRIN; BICARBONATE; ESTER DERIVATIVE; FLURBIPROFEN; TRIACYLGLYCEROL LIPASE;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); DISPERSION; ENANTIOMER; PRECIPITATION; PURIFICATION;

EID: 27944434203     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2005.08.006     Document Type: Article

References (15)

1. P.J. Hayball Drugs 52 1996 47
2. M.F. Landoni, and A. Soraci Curr. Drug. Metab. 2 2001 37
3. M. Petesen Curr. Opin. Biotechnol. 10 1999 593
4. J.D. Stewart Curr. Opin. Chem. Biol. 5 2001 120
5. I.J. Colton, S.N. Ahmed, and R.J. Kazlauskas J. Org. Chem. 60 1995 212
6. E.G. Lee, H.S. Won, and B.H. Chung Process Biochem. 37 2001 293
7. Y.Y. Liu, J.H. Xu, and Y. Hu J. Mol. Catal. B Enzym. 10 2000 523
8. A. Ghanem, and V. Schurig Tetrahedron: Asymmetry 12 2001 2761
9. Y. Mine, K. Fukunaga, K. Itoh, M. Yoshimoto, K. Nakao, and Y. Sugimura J. Biosci. Bioeng. 95 2003 441
10. S.H. Kim, T.K. Kim, G.S. Shin, K.W. Lee, H.D. Shin, and Y.H. Lee Biotechnol. Lett. 26 2004 965
11. K.W. Lee, H.A. Bae, G.S. Shin, Y.H. Lee, Enzym. Microb. Technol., in press.
12. G.S. Shin, K.W. Lee, T.K. Kim, H.D. Shin, and Y.H. Lee J. Mol. Catal. B Enzym. 33 2005 93
13. C.S. Chang, S.W. Tasi, and K. Jimmy Biotechnol. Bioeng. 64 1998 120
14. S. Fanali J. Chromatogr. A 875 2000 89
15. C. de Garcia Venturini, J. Andreaus, V.G. Machado, and C. Machado Org. Biomol. Chem. 7 2005 1751