An illustration that statistical design mitigates environmental variation and ensures unambiguous study conclusions

Animal Welfare

Volumn 14, Issue 4, 2005, Pages 361-365

  Gore, K H ^a   Stanley, Phil J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Animal welfare; Environmental variation; Latin Square; Reduction; Statistical design; Three Rs

Indexed keywords

ANALYTICAL ERROR; ANIMAL EXPERIMENT; ANIMAL TESTING REDUCTION; ANIMAL TESTING REFINEMENT; ANIMAL TESTING REPLACEMENT; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; ETHICS; EXPERIMENTAL ANIMAL WELFARE; FEMALE; MEDICAL RESEARCH; METHODOLOGY; MOUSE; NONHUMAN; RANDOMIZATION; STATISTICAL ANALYSIS;

ANIMALIA;

EID: 27844593062     PISSN: 09627286     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Cochran WG and Cox GM 1957 Experimental Designs, 2nd Edition. John Wiley & Son: New York, USA
2. Cox DR 1958 Planning of Experiments. John Wiley & Son: New York, USA
3. Festing MFW, Overend P, Gaines Das R, Cortina Borja M and Berdoy M 2002 The Design of Animal Experiments. Laboratory Animal Handbooks Number 14. RSM Press: London, UK
4. Russell WMS and Burch RL 1959 (reprinted 1992) The Principles of Humane Experimental Technique. Universities Federation for Animal Welfare: Wheathampstead, UK
5. Steel RGD and Torrie JH 1980 Principles and Procedures of Statistics, 2nd Edition. McGraw-Hill: New York, USA