Ezetimibe/simvastatin (Vytorin) for hypercholesterolemia

American Family Physician

Volumn 72, Issue 10, 2005, Pages

  Goldman Levine, Jennifer D ^a,b,c   Bohlman, Lyle G ^b  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Pharmacy ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; ANTIFUNGAL AGENT; ATORVASTATIN; EZETIMIBE; EZETIMIBE PLUS SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; LIVER ENZYME; MACROLIDE; MEVINOLIN; PYRROLE DERIVATIVE; SIMVASTATIN; UNCLASSIFIED DRUG;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; DIET; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; HEADACHE; HUMAN; HYPERCHOLESTEROLEMIA; INFLUENZA; LOW DRUG DOSE; MYALGIA; MYOPATHY; PAIN; RHABDOMYOLYSIS; SHORT SURVEY; UPPER RESPIRATORY TRACT INFECTION;

ANTILIPEMIC AGENTS; AZETIDINES; CLINICAL TRIALS; DRUG COMBINATIONS; HUMANS; HYPERCHOLESTEROLEMIA; SIMVASTATIN;

EID: 27844560120     PISSN: 0002838X     EISSN: 0002838X     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (7)

1. Vytorin (ezetimibe/simvastatin). Package insert. North Wales, Pa. Merck/Schering-Plough Pharmaceuticals. March 2005. Accessed online August 22, 2005, at: http://www.vytorin.com/vytorin/shared/documents/vytorin_pi.pdf.
2. Ballantyne CM, Blazing MA, King TR, Brady WE, Palmisano J. Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia. Am J Cardiol 2004;93:1487-94.
3. Davidson MH, McGarry T, Bettis R, Melani L, Lipka LJ LeBeaut AP, et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 2002;40:2125-34.
4. Feldman T, Koren M, Insull W Jr, McKenney J, Schrott H, Lewin A, et al. Treatment of high-risk patients with ezetimibe plus simvastatin co-administration versus simvastatin alone to attain National Cholesterol Education Program Adult Treatment Panel III low-density lipoprotein cholesterol goals. Am J Cardiol 2004;93:1481-6.
5. Goldberg AC, Sapre A, Liu J, Capece R, Mitchel YB; Ezetimibe Study Group. Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: a randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2004;79:620-9.
6. Ballantyne CM, Abate N, Yuan Z, King TR, Palmisano J. Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: the Vytorin Versus Atorvastatin (VYVA) study. Am Heart J 2005;149:464-73.
7. Zocor (simvastatin). Package insert. Whitehouse Station, N.J. Merck & Co, Inc. August 2005. Accessed online August 22, 2005, at: http://www.zocor. com/zocor/shared/documents/english/pi.pdf.