Proton nuclear magnetic resonance spectroscopy (NMR) methods for determining the purity of reference drug standards and illicit forensic drug seizures

Journal of Forensic Sciences

Volumn 50, Issue 6, 2005, Pages 1342-1360

  Hays, Patrick A ^a,b  

^a Drug Enforcement Administration   (United States)

^b DEA Special Testing and Research Laboratory   (United States)

Author keywords

Drug analysis; Forensic science; NMR; Nuclear magnetic resonance spectroscopy; Quantitative; Reference standard authentication

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ACID; COCAINE; DEUTERIUM OXIDE; DIAMORPHINE; HYDROGEN; ILLICIT DRUG; MALEIC ACID; METHAMPHETAMINE; SOLVENT; WATER;

ACCURACY; ARTICLE; CORRELATION COEFFICIENT; DRUG DETERMINATION; DRUG PURITY; DRUG SOLUBILITY; FORENSIC SCIENCE; HYDRATION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ASSAY; REPRODUCIBILITY; STANDARD;

EID: 27844543753     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: 10.1520/jfs2005124     Document Type: Article

References (14)

1. Groombridge CJ. NMR spectroscopy in forensic science. (Academic Press) Annual Reports on NMR Spectroscopy 1996;32:215-97.
2. 1H NMR: Development and potential of a method for natural products analysis. J Nat Prod 2005;68:133-49.
3. Alexander TG, Koch SA. The role of nuclear magnetic resonance in the analysis of pharmaceuticals. JAOAC 1965;48(3):618-21.
4. Rackham DM. Quantitative analysis in pharmacy and pharmaceutical chemistry by nuclear magnetic resonance spectroscopy. Talanta 1970;17:895-906.
5. Sobol SP, Barron RP, Kram TC. The use of NMR and mass spectral data in the forensic laboratory. JAOAC 1972;55(4):866-73.
6. Rackham DM. Recent applications of quantitative nuclear magnetic resonance spectroscopy in pharmaceutical research. Talanta 1976;23:269-74.
7. Kram TC. Analysis of illicit drug exhibits by hydrogen-1 nuclear magnetic resonance spectroscopy. J Forensic Sci 1978;23(3):456-69.
8. Huizer H. The use of gas chromatography for the detection and quantitation of abused drugs. In: Gough T, editor. The analysis of drugs of abuse. Chichester: Wiley, 1991;23-92.
9. Larsen AK, Weilbo D. In: Tebbett I, editor. Gas chromatography in forensic science. Chichester: Ellis Horwood, 1992;27-51.
10. Wittwer JD. Adsorption chromatography and the use of silica. In: Lurie IS, Wittwer JD, editors. High performance liquid chromatography in forensic chemistry. New York: Marcel Dekker, 1983;53-160.
11. Caddy B. The use of high performance liquid chromatography for the detection and quantitation of abused drugs. In: Gough T, editor. The analysis of drugs of abuse. Chichester: Wiley, 1991;121-73.
12. Thormann W, Wey AB, Lurie IS, Gerber H, Byland C, Malik N, Hochmeister M, Gehrig C. Capillary electrophoresis in clinical and forensic analysis: Recent advance and breakthrough to routine applications. Electrophoresis 1999;20:3203-36.
13. Lurie IS, Hays PA, Parker K. Capillary electrophoresis analysis of a wide variety of seized drugs using the same capillary with dynamic coatings. Electrophoresis 2004;25:1580-91.
14. Hays PA. Authentication procedures for reference drug standards. Microgram 1994;27:14.