Pharmacokinetics of glutathione and its metabolites in normal subjects

Journal of Korean Medical Science

Volumn 20, Issue 5, 2005, Pages 721-726

  Hong, Sae Yong ^a   Gil, Hyo Wook ^a   Yang, Jong Oh ^a   Lee, Eun Young ^a   Kim, Hyung Kee ^a   Kim, Soo Hyun ^b   Chung, Young Ho ^b   Hwang, Soo Kyung ^b   Lee, Zee Won ^b  

^a Soonchunhyang University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

Cysteine; Cystine; Glutathione; Methionine; Paraquat; Pharmacokinetics; Reactive Oxygen Species

Indexed keywords

EID: 27744596068     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.2005.20.5.721     Document Type: Article

References (26)

1. Proudfoot AT, Prescott LF, Jarvie DR. Haemodialysis for paraquat poisoning. Hum Toxicol 1987; 6: 69-74.
2. Okonek S, Hofmann A, Henningsen B. Efficacy of gut lavage, hemodialysis, and hemoperfusion in the therapy of paraquat or diquat intoxication. Arch Toxicol 1976; 36: 43-51.
3. Meredith TJ, Vale JA. Treatment of paraquat poisoning in man: methods to prevent absorption. Hum Toxicol 1987; 6: 49-55.
4. Okonek S. Hemoperfusion in toxicology. Basic considerations of its effectiveness. Clin Toxicol 1981; 18: 1185-98.
5. Lock EA, Smith LL, Rose MS. Inhibition of paraquat accumulation in rat lung slices by a component of rat plasma and a variety of drugs and endogenous amines. Biochem Pharmacol 1976; 25: 1769-72.
6. Ross JH, Krieger RI. Structure-activity correlations of amines inhibiting active uptake of paraquat (methyl viologen) into rat lung slices. Toxicol Appl Pharmacol 1981; 59: 238-49.
7. Kitazawa Y, Matsubara M, Takeyama N, Tanaka T. The role of xanthine oxidase in paraquat intoxication. Arch Biochem Biophys 1991; 288: 220-4.
8. Webb DB, Williams MV, Davies BH, James KW. Resolution after radiotherapy of severe pulmonary damage due to paraquat poisoning. Br Med J (Clin Res Ed) 1984; 288: 1259-60.
9. Lin JL, Leu ML, Liu YC, Chen GH. A prospective clinical trial of pulse therapy with glucocorticoid and cyclophosphamide in moderate to severe paraquat-poisoned patients. Am J Respir Crit Care Med 1999; 159: 357-60.
10. Bus JS, Cagen SZ, Olgaard M, Gibson JE. A mechanism of paraquat toxicity in mice and rats. Toxicol Appl Pharmacol 1976; 35: 501-13.
11. Hagen TM, Brown LA, Jones DP. Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells. Biochem Pharmacol 1986; 35: 4537-42.
12. Brown LA, Bai C, Jones DP. Glutathione protection in alveolar type II cells from fetal and neonatal rabbits. Am J Physiol 1992; 262: L305-12.
13. Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983; 52: 711-60.
14. Jurima-Romet M, Barber RF, Demeester J, Shek PN. Distribution studies of liposome-encapsulated glutathione administered to the lung. Int J Pharm 1990; 63: 227-35.
15. Smith LJ, Anderson J, Shamsuddin M. Glutathione localization and distribution after intratracheal instillation. Implications for treatment. Am Rev Respir Dis 1992; 145: 153-9.
16. Reed DJ, Ellis WW, Meek RA. The inhibition of gamma-glutamyl transpeptidase and glutathione mtabolism of isolated rat kidney cells by L-(alpha S, 5S)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazole-acetic acid (AT-125; NSC-163501). Biochem Biophys Res Commun 1980; 94: 1273-7.
17. Rajpert-De Meyts E, Shi M, Chang M, Robison TW, Groffen J, Heisterkamp N, Forman HJ. Transfection with gamma-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione. Toxicol Appl Pharmacol 1992; 114: 56-62.
18. Mudd SH, Levy JL. Disorders of transsulphuration. In Stanbury, J.B., editor. Metabolic bases of inherited disease (5th ed.). McGraw-Hill, New York, 1982; 522-59.
19. Stipanuk MH, Benevenga NJ. Effect of cystine on the metabolism of methionine in rats. J Nutr 1977; 107: 1455-67.
20. Storch KJ, Wagner DA, Burke JF, Young VR. [1-13C; methyl-2H3] methionine kinetics in humans: methionine conservation and cystine sparing. Am J Physiol 1990; 258: E790-8.
21. Young VR, Wagner DA, Burini R, Storch, KJ. Methionine kinetics and balance at the 1985 FAO/WHO/UNU intake requirement in adult men studied with L-[2H3-methyl-1-13C]methionine as a tracer. Am J Clin Nutr 1991; 54: 377-85.
22. Aebi S, Assereto R, Lauterburg BH. High-dose intravenous glutathione in man. Pharmacokinetics and effects on cyst(e)ine in plasma and urine. Eur J Clin Invest 1991; 21: 103-10.
23. 2 by transforming growth factor-β in Swiss 3T3 fibroblasts. Cell Signal 1999; 11: 677-83.
24. Neuschwander-Tetri BA, Roll FJ. Glutathione measurement by high-performance liquid chromatography separation and fluorometric detection of the glutathione-orthophthalaldehyde adduct. Anal Biochem 1989; 179: 236-41.
25. Cereser C, Guichard J, Drai J, Bannier E, Garcia I, Boget S, Parvaz P, Revol A. Quantitation of reduced and total glutathione at the femtomole level by high-performance liquid chromatography with fluorescence detection: application to red blood cells and cultured fibroblasts. J Chromatogr B Biomed Sci Appl 2001; 752: 123-32.
26. Tarr GE. Methods of protein measurement. In: Shively, J.E. editor. Microcharacterization. Humana Press, USA 1986; 155-94.