Traceless solid-phase synthesis of N1,N7-disubstituted purines

Journal of Combinatorial Chemistry

Volumn 7, Issue 5, 2005, Pages 734-738

  Fu, Han ^a   Lam, Yulin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PURINE DERIVATIVE;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; METHODOLOGY; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; PURINES;

EID: 27744591719     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc050058f     Document Type: Article

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16. 3 in refluxing methanol enabled both N1-alkylation and transesterification to occur. This was evidenced by the quaternized product, 3-(1,7-dibutyl-6-oxo-1,6-dihydro-purin-9-yl)-propionic acid methyl ester salt, 13 obtained.