Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 1, 2006, Pages 77-80

  Sehon, Clark ^a   McClure, Kelly ^a   Hack, Michael ^a   Morton, Magda ^a   Gomez, Laurent ^a   Li, Lina ^a   Barrett, Terrance D ^a   Shankley, Nigel ^a   Breitenbucher, J Guy ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Additivity; CCK1; Cholecystokinin; Combinatorial; QSAR

Indexed keywords

CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; PYRAZOLE DERIVATIVE;

ARTICLE; COMBINATORIAL CHEMISTRY; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; RECEPTOR BINDING; SOLID; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

CHEMISTRY, PHARMACEUTICAL; CHOLECYSTOKININ; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; MODELS, STATISTICAL; PEPTIDE LIBRARY; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PYRAZOLES; RECEPTOR, CHOLECYSTOKININ A; REGRESSION ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744583278     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.041     Document Type: Article

References (7)

1. For recent comprehensive reviews of CCK pharmacology and medicinal chemistry see R. Herranz Med. Res. Rev. 23 2003 559
2. P. Tullio, J. Delarge, and B. Pirotte Exp. Opin. Investig. Drugs 9 2000 129
3. G. Varga Curr. Opin. Invest. Drugs 3 2002 621
4. K. McClure, L. Huang, C. Sehon, M. Hack, M. Morton, T. Barrett, N. Shankley, and J.G. Breitenbucher Bioorg. Med. Chem. Lett. 2005 accompanying paper
5. D.-M. Shen, M. Shu, and K.T. Chapman Org. Lett. 2 2000 2789
6. K. Plucinska, T. Kataoka, M. Yodo, W.L. Cody, J.X. He, C. Humblot, G.H. Lu, E. Lunney, T.C. Major, R.T. Panek, P. Schelkum, R. Skeean, and G.R. Marshall J. Med. Chem. 36 1993 1902
7. A. Cammareta J. Med. Chem. 15 1972 573