Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous disease

Journal of Investigative Dermatology

Volumn 125, Issue 4, 2005, Pages 705-710

  Goebel, W Scott ^a   Mark, Lawrence A ^a   Billings, Steven D ^a   Meyers, Justin L ^a   Pech, Nancy ^a   Travers, Jeffrey B ^a   Dinauer, Mary C ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Chronic granulomatous disease; Inflammation; Neutrophil; Skin; Transgenic knockout

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE REPLACEMENT THERAPY; GENE THERAPY; GENE TRANSFER; GRANULOMA; GRANULOMATOSIS; HEMATOPOIETIC STEM CELL; INFLAMMATION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; REDUCTION; WILD TYPE; X CHROMOSOME LINKAGE; ANIMAL; ASPERGILLUS FUMIGATUS; C57BL MOUSE; DERMATITIS; GENETIC LINKAGE; GENETICS; RETROVIRUS; X CHROMOSOME;

ANIMALS; ASPERGILLUS FUMIGATUS; DERMATITIS; FEMALE; GENE THERAPY; GRANULOMA; GRANULOMATOUS DISEASE, CHRONIC; LINKAGE (GENETICS); MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NADPH OXIDASE; RETROVIRIDAE; X CHROMOSOME;

EID: 27744577299     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23908.x     Document Type: Article

References (18)

1. Barese CN, Goebel WS, Dinauer MC: Gene therapy for chronic granulomatous disease. Expert Opin Biol Ther 4:1423-1434, 2004
2. Bjorgvinsdottir H, Ding C, Pech N, Gifford M, Li L, Dinauer M: Retroviral-mediated gene transfer of gp91phox into bone marrow cells rescues in host defense against Aspergillus fumigatus in murine X-linked chronic granulomatous disease. Blood 89:41-48, 1997
3. Brown JR, Goldblatt D, Buddle J, Morton L, Thrasher AJ: Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). J Leukoc Biol 73:591-599, 2003
4. Dinauer M: The phagocyte system and disorders of granulopoiesis and granulocyte function. In: Nathan D, Orkin S, Ginsburg D, Look A (eds). Nathan and Oski's Hematology of Infancy and Childhood. Philadelphia: W.B. Saunders Company, 2003; p 923-1010
5. Dinauer M, Li L, Bjorgvinsdottir H, Ding C, Pech N: Long-term correction of phagocyte NADPH oxidase activity by retroviral-mediated gene transfer in murine X-linked chronic granulomatous disease. Blood 94:914-922, 1999
6. Dinauer MC, Gifford MA, Pech N, Li LL, Emshwiller P: Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease. Blood 97:3738-3745, 2001
7. Dohil M, Prendiville JS, Crawford RI, Speert DP: Cutaneous manifestations of chronic granulomatous disease. A report of four cases and review of the literature. J Am Acad Dermatol 36:899-907, 1997
8. Foster C, Lehrnbecher T, Mol F, et al: Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. J Clin Invest 102:2146-2155, 1998
9. Gallin J, Buescher E, Seligmann B, Nath J, Gaither T, Katz P: Recent advances in chronic chronic granulomatous disease. Ann Int Med 99:657-674, 1983
10. Mardiney M, Jackson S, Spratt S, Li F, Holland S, Malech H: Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease. Blood 89:2268-2275, 1997
11. Morgenstern D, Gifford M, Li L, Doerschuk C, Dinauer M: Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. J Exp Med 185:207-218, 1997
12. Ottonello L, Frumento G, Arduino N, Bertolotto M, Dapino P, Mancini M, Dallegri F: Differential regulation of spontaneous and immune complex-induced neutrophil apoptosis by proinflammatory cytokines. Role of oxidants, bax and caspase-3. J Leukoc Biol 72:125-132, 2002
13. Petersen JE, Hiran TS, Goebel WS, et al: Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease. J Invest Dermatol 118:424-429, 2002
14. Pollock J, Williams D, Gifford M, et al: Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet 9:202-209, 1995
15. Rupec RA, Petropoulou T, Belohradsky BH, Walchner M, Liese JG, Plewing G, Messer G: Lupus erythematosus tumidus and chronic discoid lupus erythematosus in carriers of X-linked chronic granulomatous disease. Eur J Dermatol 10:184-189, 2000
16. Segal A: The NADPH oxidase and chronic granulomatous disease. Mol Med Today 2:129-135, 1996
17. Segal B, Leto T, Gallin J, Malech H, Holland S: Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore) 79:170-200, 2000
18. Segal BH, Kuhns DB, Ding L, Gallin JI, Holland SM: Thioglycollate peritonitis in mice lacking c5, 5-lipoxygenase, or p47phox: Complement, leukotrienes, and reactive oxidants in acute inflammation. J Leukoc Biol 71:410-416, 2002