Severe hypothermia in association with sodium valproate overdose

New Zealand Medical Journal

Volumn 118, Issue 1223, 2005, Pages

  Robinson, Philip C ^a   Abbott, Chris G ^b  

^a WELLINGTON HOSPITAL   (New Zealand)

^b NELSON HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMYLASE; CREATINE KINASE; GLUCOSE; HEMOGLOBIN; NALOXONE; PARACETAMOL; SALICYLIC ACID; SODIUM; THIAMINE; VALPROIC ACID; GABAERGIC RECEPTOR AFFECTING AGENT;

ADULT; APNEA; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTICLE; ARTIFICIAL VENTILATION; BLADDER IRRIGATION; BRADYCARDIA; CASE REPORT; CORE TEMPERATURE; CREATINE KINASE BLOOD LEVEL; DISEASE SEVERITY; DRUG OVERDOSE; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY; EXTUBATION; GLASGOW COMA SCALE; HEART ATRIUM FIBRILLATION; HOSPITAL ADMISSION; HUMAN; HYPOGLYCEMIA; HYPOTENSION; HYPOTHERMIA; INTENSIVE CARE UNIT; INTUBATION; MALE; PH; RESUSCITATION; SINUS RHYTHM; THERMOREGULATION; CHEMICALLY INDUCED DISORDER; INTOXICATION; METHODOLOGY; TREATMENT OUTCOME; WARMING;

ADULT; GABA AGENTS; HUMANS; HYPOTHERMIA; MALE; OVERDOSE; REWARMING; TREATMENT OUTCOME; VALPROIC ACID;

EID: 27744571267     PISSN: 11758716     EISSN: 11758716     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Zachariah SB, Zachariah BS, Ananda R, Stewart JT. Hypothermia and thermoregulatory derangements induced by valproic acid. Neurology. 2000;55:150.
2. Nagarajan L. & Williams S. Hypothermia and thermoregulatory derangements induced by valproic acid [response]. Neurology. 2001;56:139.
3. Ginefri-Gayet M and Gayet J. Hypothermia induced by infusion of methioine sulfoximime into the dorsal raphe nucleus of the rat: involvement of 5-HT1A and GABA-B receptors. European Journal of Pharmacology. 1993;235:189-96.
4. Queva C, Bremner-Dianelsen M, Edlund A et al. Effects of GABA agonists on body temperature regulation in (1))-/- mice. British Journal of Pharmacology. 2003;140:315-22.
5. Serrano JS, Minano FJ, Sancibrian M and Duran JA. Involvement of bucuculline-insensitive receptors in the hypothermia effect of GABA and its agonists. General Pharmacology. 1985:16:505-8.
6. Epilim EC data sheet, New Zealand Medicines and Medical Devices Safety Authority. Wellington: Medsafe New Zealand. Available online. URL: http://www.medsafe.govt.nz/profs/Datasheet/e/Epilimtabsyrliq.htm Accessed September 2005.
7. Sodium Valproate Toxinz Sheet. Dunedin: National Poisons Centre, New Zealand. Search at http://www.toxinz.com (not archived)
8. Garnier R, Fournier E. Intoxication aigue par le valproate de sodium. Nouv Presse Med. 1982;11:678.
9. Spiller HA, Krenzelok EP, Klein-Schwartz W, et al. Multicenter case series of valproic acid ingestion: serum concentrations and toxicity. J Toxicol Clin Toxicol. 2000;38:755-60.
10. Isbister GK, Balit CR, Dawson AH, Whyte IM. Valproate Poisoning: a comparative cohort study of self poisonings. Br J Clin Pharm. 2003;55:398-404.