A semi-automated procedure for the determination of caspofungin in human plasma using solid-phase extraction and HPLC with fluorescence detection using secondary ionic interactions to obtain a highly purified extract

Journal of Liquid Chromatography and Related Technologies

Volumn 28, Issue 18, 2005, Pages 2895-2908

  Bi, Sheng ^a   Schwartz, M S ^a   Desai, R B ^a   Miller, A R ^a   Matuszewski, B K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Caspofungin; Fluorescence detection; HPLC; Secondary ionic interactions; Solid phase extraction

Indexed keywords

AUTOMATION; DRUG PRODUCTS; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PLASMAS; PROGRAM PROCESSORS; ROBOTICS;

CASPOFUNGIN; FLUORESCENCE DETECTION; HPLC; SECONDARY IONIC INTERACTIONS; SOLID-PHASE EXTRACTION;

BODY FLUIDS;

AMMONIUM DERIVATIVE; CASPOFUNGIN; HYDROXIDE; METHANOL; TRIFLUOROACETIC ACID; WATER;

ACCURACY; ARTICLE; AUTOMATION; CALIBRATION; CENTRIFUGATION; COVARIANCE; DISSOLUTION; ELUTION; EVAPORATION; EXTRACT; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MOLECULAR INTERACTION; PLASMA; PURIFICATION; ROBOTICS; SOLID PHASE EXTRACTION;

EID: 27744568294     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070500271915     Document Type: Article

References (8)

1. Bartizal, K. Cutaneous Antifungal Agents; Rippon, J., Ed.; Marcel Dekker, Inc: New York, 1993; Chap. 29.
2. Bartizal, K.; Flattery, A.; Lynch, L.; Pacholok, C.; Gill, C.; Rosen, H.; Scott, P.; Kropp, H. Interscience Conference on Antimicrobial Agents and Chemotherapy, 36th Congress, New Orleans, Louisiana, 9/15/1996; Abstract F32.
3. Smith, J.; Abruzzo, G.; Gill, C.; Flattery, A.; Kong, L.; Rosen, H.; Kropp, H.; Bartizal, K. Interscience Conference on Antimicrobial Agents and Chemotherapy, 36th Congress, Louisiana, 9/15/1996; Abstract F41.
4. Flattery, A.; Abruzzo, G.; Smith, J.; Gill, D.; Rosen, H.; Kropp, H.; Bartizal, K. Interscience Conference on Antimicrobial Agents and Chemotherapy, 36th Congress, Louisiana, 9/15/1996; Abstract F40.
5. Hajdu, R.; Pelak, B.; Sundelof, J.; Thompson, R.; Rosen, H.; Kropp, H. Interscience Conference on Antimicrobial Agents and Chemotherapy, 36th Congress, Louisiana, 9/15/1996; Abstract F44.
6. Schwartz, M.; Kline, W.; Matuszewski, B. Analytica Chimica Acta 1997, 352, 299-307.
7. Chavez-Eng, C.M.; Schwartz, M.; Constanzer, M.L.; Matuszewski, B. J. Chromatogr. B 1999, 721, 229-238,
8. Wells, D.A. LC GC 1999, 17, 600.