Characterization of [3H]-forskolin binding sites in young and adult rat brain cortex: Identification of suramin as a competitive inhibitor of [3H]-forskolin binding

Canadian Journal of Physiology and Pharmacology

Volumn 83, Issue 7, 2005, Pages 573-581

  Stöhr, Jiri ^b   Novotny, Jiri ^a   Svoboda, Petr ^b  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b NONE

Author keywords

Development; Forskolin binding; Rat brain cortex; Suramin

Indexed keywords

ADENYLATE CYCLASE; ALUMINUM FLUORIDE; BACLOFEN; FORSKOLIN; GUANOSINE TRIPHOSPHATE DERIVATIVE; ISOPRENALINE; MAGNESIUM CHLORIDE; MAGNESIUM ION; SURAMIN; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG RECEPTOR; GUANYLYLIMIDODIPHOSPHATE; MAGNESIUM;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BRAIN CORTEX; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFECT; ENZYME ACTIVITY; MALE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; RAT; AGING; ANIMAL; CELL MEMBRANE; METABOLISM; WISTAR RAT;

ADRENERGIC BETA-AGONISTS; AGING; ANIMALS; BACLOFEN; BINDING, COMPETITIVE; CELL MEMBRANE; CEREBRAL CORTEX; FORSKOLIN; GABA AGONISTS; GUANYLYL IMIDODIPHOSPHATE; ISOPROTERENOL; MAGNESIUM; MALE; RATS; RATS, WISTAR; RECEPTORS, DRUG; SURAMIN;

EID: 27744563294     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y05-048     Document Type: Article

References (40)

1. Alousi, A.A., Jasper, J.R., Insel, P.A., and Motulsky, H.J. 1991. Stoichiometry of receptor-Gs-adenylate cyclase interactions. FASEB. J. 5: 2300-2303.
2. Beindl, W., Mitterauer, T., Hohenegger, M., Ijzerman, A.P., Nanoff, C., and Freissmuth, M. 1996. Inhibition of receptor/G protein coupling by suramin analogues. Mol. Pharmacol. 50: 415-423.
3. Butler, S.J., Kelly, E.C., McKenzie, F.R., Guild, S.B., Wakelam, M.J., and Milligan, G. 1988. Differential effects of suramin on the coupling of receptors to individual species of pertussistoxin-sensitive guanine-nucleotide- binding proteins. Biochem. J. 251: 201-205.
4. Daly, J.W., Padgett, W., and Seamon, K.B. 1982. Activation of cyclic AMP-generating systems in brain membranes and slices by the diterpene forskolin: augmentation of receptor-mediated responses. J. Neurochem. 38: 532-544.
5. Dessauer, C.W., Tesmer, J.J., Sprang, S.R., and Gilman, A.G. 1998. Identification of a Giα binding site on type V adenylyl cyclase. J. Biol. Chem. 273: 25831-25839.
6. Firsching, A., Nickel, P., Mora, P., and Allolio, B. 1995. Antiproliferative and angiostatic activity of suramin analogues. Cancer Res. 55: 4957-4961.
7. 3H]forskolin binding in the rat brain by guanylyl-5'-imidodiphosphate and sodium fluoride: comparison with the distribution of guanine nucleotide binding sites. J. Pharmacol. Exp. Ther. 239: 952-958.
8. 3H] forskolin binding sites in the rat brain. Brain Res. 361: 351-360.
9. 3H]forskolin binding sites in the irisciliary body of the albino rabbit. Life Sci. 42: 1307-1314.
10. Huang, R.R., Dehaven, R.N., Cheung, A.H., Diehl, R.E., Dixon, R.A., and Strader, C.D. 1990. Identification of allosteric antagonists of receptor-guanine nucleotide-binding protein interactions. Mol. Pharmacol. 37: 304-310.
11. Ihnatovych, I, Novotny, J., Haugvicova, R., Bourova, L., Mares, P., and Svoboda, P. 2002a. Ontogenetic development of the G protein-mediated adenylyl cyclase signalling in rat brain. Brain Res. Dev. Brain Res. 133: 69-75.
12. Ihnatovych, I, Novotny, J., Haugvicova, R., Bourova, L., Mares, P., and Svoboda, P. 2002b. Opposing changes of trimeric G protein levels during ontogenetic development of rat brain. Brain Res. Dev. Brain Res. 133: 57-67.
13. Insel, P.A., and Ostrom, R.S. 2003. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell. Mol. Neurobiol. 23: 305-314.
14. 3H]forskolin binding sites. Biochem. Pharmacol. 35: 2247-2251.
15. Jennings, F.W., Rodgers, J., Bradley, B., Gettinby, G., Kennedy, P.G., and Murray, M. 2002. Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen. Parasitol. Int. 51: 381-388.
16. Kaur, M., Reed, E., Sartor, O., Dahut, W., and Figg, W.D. 2002. Suramin's development: what did we learn? Invest. New Drugs. 20: 209-219.
17. Keshles, O., and Levitzki, A. 1984. The ontogenesis of beta-adrenergic receptors and of adenylate cyclase in the developing rat brain. Biochem. Pharmacol. 33: 3231-3233.
18. Khaled, Z., Rideout, D., O'Driscoll, K.R., Petrylak, D., Cacace, A., Patel, R., et al. 1995. Effects of suramin-related and other clinically therapeutic polyanions on protein kinase C activity. Clin. Cancer Res. 1: 113-122.
19. Klinger, M., Freissmuth, M., Nickel, P., Stabler-Schwarzbart, M., Kassack, M., Suko, J., et al. 1999. Suramin and suramin analogs activate skeletal muscle ryanodine receptor via a calmodulin binding site. Mol. Pharmacol. 55: 462-472.
20. Klinger, M., Bofill-Cardona, E., Mayer, B., Nanoff, C., Freissmuth, M., and Hohenegger, M. 2001. Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem. J. 355: 827-833.
21. Matsuoka, I., Suzuki, Y., Defer, N., Nakanishi, H., and Hanoune, J. 1997. Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain. J. Neurochem. 68: 498-506.
22. Mills, G.B., Zhang, N., May, C., Hill, M., and Chung, A. 1990. Suramin prevents binding of interleukin 2 to its cell surface receptor: a possible mechanism for immunosuppression. Cancer Res. 50: 3036-3042.
23. Minniti, C.P., Maggi, M., and Helman, L.J. 1992. Suramin inhibits the growth of human rhabdomyosarcoma by interrupting the insulin-like growth factor II autocrine growth loop. Cancer Res. 52: 1830-1835.
24. Musser, B., Mudumbi, R.V., Liu, J., Olson, R.D., and Vestal, R.E. 1999. Adenosine Al receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. J. Pharmacol. Exp. Ther. 288: 446-454.
25. 3H] forskolin binding to human platelet membranes by GppNHp, NaF, and prostaglandin E1. FEBS. Lett. 183: 349-352.
26. Nelson, C.A., and Seamon, K.B. 1986. Binding of [3H]forskolin to human platelet membranes. Regulation by guanyl-5'-yl imido-diphosphate, NaF, and prostaglandins E1 and D2. J. Biol. Chem. 261: 13469-13473.
27. 3H]forskolin binding to rat cerebral cortical membranes. Prog. Neuropsycho-pharmacol. Biol. Psychiatry. 15: 709-716.
28. Poat, J.A., Cripps, H.E., and Iversen, L.L. 1988. Differences between high-affinity forskolin binding sites in dopamine-rich and other regions of rat brain. Proc. Natl. Acad. Sci. U. S. A. 85: 3216-3220.
29. Post, S.R., Hilal-Dandan, R., Urasawa, K., Brunton, L.L., and Insel, P.A. 1995. Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem. J. 311: 75-80.
30. Post, S.R., Aguila-Buhain, O., and Insel, P.A. 1996. A key role for protein kinase A in homologous desensitization of the beta 2-adrenergic receptor pathway in S49 lymphoma cells. J. Biol. Chem. 271: 895-900.
31. Ross, B., Dawson, D., Dewar, D., Macrae, M., Knowler, J., and McCulloch, J. 1993. Effects of post-mortem delay on high affinity forskolin binding sites and adenylate cyclase activity in rat and human striatum and cerebral cortex. Brain Res. 629: 225-230.
32. Ryan, C.W., Vokes, E.E., Vogelzang, N.J., Janisch, L., Kobayashi, K., and Ratain, M.J. 2002. A phase I study of suramin with once- or twice-monthly dosing in patients with advanced cancer. Cancer Chemother. Pharmacol. 50: 1-5.
33. Seamon, K.B., and Daly, J.W. 1981. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucleotide Res. 7: 201-224.
34. Seamon, K.B., and Daly, J.W. 1985. High-affinity binding of forskolin to rat brain membranes. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 19: 125-135.
35. Seamon, K.B., Padgett, W., and Daly, J.W. 1981. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc. Natl. Acad. Sci. U. S. A. 78: 3363-3367.
36. 3H]forskolin to rat brain membranes. Proc. Natl. Acad. Sci. U. S. A. 81: 5081-5085.
37. Seamon, K.B., Vaillancourt, R., and Daly, J.W. 1985. Modulation of forskolin binding to rat brain membranes. J. Cyclic Nucleotide Protein Phosphorylation Res. 10: 535-549.
38. 3H]forskolin binding sites in the human caudate nucleus. Brain Res. 610: 156-161.
39. Sutkowski, E.M., Tang, W.J., Broome, C.W., Robbins, J.D., and Seamon, K.B. 1994. Regulation of forskolin interactions with type I, II, V, and VI adenylyl cyclases by Gsα. Biochemistry, 33: 12852-12859.
40. Zhang, Y.L., Keng, Y.F., Zhao, Y, Wu, L., and Zhang, Z.Y. 1998. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. J. Biol. Chem. 273: 12281-12287.