RCTs in psychiatry: Challenges and the future

Epidemiologia e Psichiatria Sociale

Volumn 14, Issue 3, 2005, Pages 127-131

  Walwyn, Rebecca ^b   Wessely, Simon ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

LITHIUM; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; VALPROIC ACID;

ACCURACY; BEHAVIOR; BIPOLAR DISORDER; CLINICAL TRIAL; COMORBIDITY; DEPRESSION; EDITORIAL; HUMAN; MENTAL DISEASE; MENTAL HEALTH; OUTCOMES RESEARCH; PREDICTION; PSYCHIATRY; PSYCHOTHERAPIST; QUALITATIVE ANALYSIS; SCHIZOPHRENIA; VALIDATION PROCESS;

EID: 27744562788     PISSN: 1121189X     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1121189X00006369     Document Type: Editorial

References (18)

1. Burns T., Creed F., Fahy T., Thompson, S., Tyrer P. & White I. (1999). Intensive versus standard case management for severe psychotic illness: A randomised trial. Lancet 353 (9171), 2185-2189.
2. Collins R., Peto R., Gray R. & Parish S. (1996). Large scale randomized evidence: Trials and overviews. In Oxford Textbook of Medicine, 3rd ed. (Ed. D. Weatherall, J. Ledingham and D. Warrell), pp. 21-32. Oxford University Press: Oxford.
3. Crawford M.J., Weaver T., Rutter D., Sensky T. & Tyrer P. (2002). Evaluating new treatments in psychiatry: The potential value of combining qualitative and quantitative research methods. International Review of Psychiatry 14(1), 6-11.
4. Everitt B. & Wessely S. (2003). Clinical Trials in Psychiatry. Oxford University Press: Oxford.
5. Geddes J. (2002). Can we conduct some large simple trials in bipolar disorder? Bipolar Disorder 4, Suppl 1, 62-63.
6. Gilbody S., Wahlbeck K. & Adams C. (2002). Randomized controlled trials in schizophrenia: a critical perspective on the literature. Acta Psychiatrica Scandinavica 105(4), 243-251.
7. Horton R. (2001). The clinical trial: deceitful, disputable, unbelievable, unhelpful, and shameful-what next? (Keynote Address). Society for Clinical Trials Annual Meeting.
8. Hotopf M., Lewis G. & Normand C. (1997). Putting trials on trial - the costs and consequences of small trials in depression: a systematic review of methodology. Journal of Epidemiology and Community Health 51(4), 354-358.
9. Johnson T. (1998). Clinical trials in psychiatry: Background and statistical perspective. Statistical Methods in Medical Research 7(3), 209-234.
10. Kroenke K., West S.L., Swindle R., Gilsenan A., Eckert G.J., Dolor R., Slang P., Zhou X.-H., Hays R. & Weinberger M. (2001). Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: A randomized trial. Journal of the American Medical Association 286(23), 2947-2955.
11. McKee M., Britton A., Black N., McPherson K., Sanderson C. & Bain C. (1999). Methods in health services research: Interpreting the evidence: Choosing between randomised and non-randomised studies. British Medical Journal 319(7205), 312-315.
12. MRC (2002). A framework for development and evaluation of RCTs for complex interventions to improve health. Retrieved May 3, 2005 from http://www.mrc.ac.uk/pdf-mrc_cpr.pdf
13. Persons J.B. & Silberschatz G. (1998). Are results of randomized controlled trials useful to psychotherapists? Journal of Consulting and Clinical Psychology 66(1), 126-135.
14. Rothwell P. (1995). Can overall results of clinical trials be applied to all patients? Lancet 345(8965), 1616-1619.
15. Stephenson J. & Imrie J. (1998). Why do we need randomised controlled trials to assess behavioural interventions? British Medical Journal 316(7131), 611-613.
16. Swartz M.S., Swanson J.W., Hiday V.A., Wagner H.R., Burns B.J. & Borum R. (2001). A randomized controlled trial of outpatient commitment in North Carolina. Psychiatric Services 52(3), 325-329.
17. Thornley B. & Adams C. (1998). Content and quality of 2000 controlled trials in schizophrenia over 50 years. British Medical Journal 317(7167), 1181-1184.
18. Tollefson G.D., Beasley C.M. Jr, Tran P.V., Street J.S., Krueger J.A., Tamura R.N., Graffeo K.A. & Thieme M.E. (1997). Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: Results of an international collaborative trial. American Journal of Psychiatry 154(4), 457-465.