Comparative assessment of the bioavailability, efficacy and safety of a modified - release (MR) carbonyl iron tablet and oral conventional iron preparation in adult Indian patients with nutritional iron deficiency anaemia

Journal of the Indian Medical Association

Volumn 103, Issue 6, 2005, Pages 338-342

  Adsul, B B ^a,b   Desai, Anish ^a   Gawde, Ashish ^a   Baliga, Vidyagauri ^a  

^a Glenmark Pharmaceuticals Limited   (India)

^b LOKMANYA TILAK MUNICIPAL GENERAL HOSPITAL   (India)

Author keywords

Carbonyl iron; Ferrous fumarate; Modified release formulation

Indexed keywords

CARBONYL IRON; FERRITIN; FERROUS FUMARATE; HEMOGLOBIN; IRON; FERROUS ION; IRON CARBONYL COMPOUNDS; ORGANOMETALLIC COMPOUND;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG CHOICE; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG TOLERABILITY; EPIGASTRIC PAIN; FEMALE; HEADACHE; HEARTBURN; HEMOGLOBIN DETERMINATION; HUMAN; IRON DEFICIENCY ANEMIA; IRON INTAKE; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; NAUSEA; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TASTE DISORDER; ADOLESCENT; BIOAVAILABILITY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHASE 3 CLINICAL TRIAL;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; ANEMIA, IRON-DEFICIENCY; BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; FEMALE; FERROUS COMPOUNDS; HUMANS; IRON; MALE; MIDDLE AGED; ORGANOMETALLIC COMPOUNDS;

EID: 27744556403     PISSN: 00195847     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Hercberg S, Galan P - Nutritional anaemias. Baillieres Clin Haematol 1992; 5: 143-68.
2. Agarwal KN - Functional consequences of nutritional anaemia. Proc Nutr Soc India 1991; 37: 127-32.
3. Thangaleela T, Vijayalakshmi P - Impact of anaemia in pregnancy. Indian J Nutr Dietetics 1994; 31: 251-6.
4. Hillman RS - Hematopoietic agents: growth factors, minerals and vitamins. In: Hardman JG, Limbird LE, editors. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw-Hill, 2001: 1487-752.
5. Devasthali SD, Gordeuk VR, Brittenham GM, Bravo JR. Hughes MA, Keating LJ - Bioavailability of carbonyl iron: a randomized, double-blind study. Eur J Haematol 1991; 46: 272-8.
6. Huebers HA, Brittenham GM, Csiba E, Finch CA - Absorption of carbonyl iron. J Lab Clin Med 1986; 108: 473-8.
7. Nakamura T, Mori M, Awai M - Process of carbonyl iron absorption from the rat duodenal mucosa. Acta Pathol Jpn 1988; 38: 1377-90.
8. Gordeuk VR, Brittenham GM, Hughes M, Keating LJ, Opplt JJ - High-dose carbonyl iron for iron-deficiency anemia: a randomized double-blind trial. Am J Clin Nutr 1987; 46: 1029-34.
9. Gordeuk VR, Brittenham GM, Bravo J, Hughes MA, Keating LJ - Prevention of iron deficiency with carbonyl iron in female blood donors. Transfusion 1990; 30: 239-45.
10. Gordeuk VR, Brittenham GM, Hughes MA, Keating LJ - Carbonyl iron for short-term supplementation in female blood donors. Transfusion 1987; 27: 80-5.
11. International Committee for Standardization in Haematology (Iron panel) - Recommendations for measurement of serum iron in human blood. Br J Haematol 1978; 38: 291-4.
12. International Committee for Standardization in Haematology (Iron panel) - Recommendations for measurement of total and unsaturated iron-binding capacity in serum. Br J Haematol 1978; 38: 281-7.
13. Haskins D, Stevens AR Jr, Finch CA - Iron metabolism: iron stores in man as measured by phlebotomy. J Clin Invest 1952; 31: 543-7.
14. Wheby MS - Effect of iron therapy on serum ferritin levels in iron-deficiency anemia. Blood 1980; 56: 138-40.