A simulation study of power in thorough QT/QTc studies and a normal approximation for planning purposes

Drug Information Journal

Volumn 39, Issue 4, 2005, Pages 447-455

  Hosmane, Balakrishna ^a   Locke, Charles ^b  

^a NORTHERN ILLINOIS UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Power; QT; Simulation; Thorough QT QTc study

Indexed keywords

ANTIARRHYTHMIC AGENT; NEW DRUG; PLACEBO;

COVARIANCE; DRUG EFFECT; DRUG SAFETY; DRUG SCREENING; HUMAN; MEASUREMENT; NORMAL DISTRIBUTION; PLANNING; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; REVIEW; RISK ASSESSMENT; SIMULATION; STATISTICAL ANALYSIS; VARIANCE;

EID: 27744551029     PISSN: 00928615     EISSN: None     Source Type: Journal    
DOI: 10.1177/009286150503900411     Document Type: Review

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