Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 1, 2006, Pages 49-54

  Pereira, Raquel ^a   Gaudon, Claudine ^b   Iglesias, Beatriz ^a   Germain, Pierre ^b   Gronemeyer, Hinrich ^b   De Lera, Angel R ^a  

^a UNIVERSITY OF VIGO   (Spain)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Nuclear receptors; PPAR; Stille reactions; Suzuki reactions; Thiazoles

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; CB676475; GLOBIN; HYDROXYBENZOIC ACID DERIVATIVE; LIGAND; LIPID; PALLADIUM; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; QUINAZOLINE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CATALYSIS; DRUG POTENCY; DRUG SYNTHESIS; LIPID OXIDATION; SUBSTITUTION REACTION; CELL LINE; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; DRUG POTENTIATION; GENETIC PROCEDURES; GENETIC TRANSCRIPTION; GENETICS; HELA CELL; HUMAN; PROMOTER REGION; REPORTER GENE; SYNTHESIS; TIME; TRANSACTIVATION;

CATALYSIS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GENES, REPORTER; GENETIC TECHNIQUES; GLOBINS; HELA CELLS; HUMANS; HYDROXYBENZOIC ACIDS; LIGANDS; LIPIDS; MODELS, CHEMICAL; PALLADIUM; PPAR DELTA; PPAR-BETA; PROMOTER REGIONS (GENETICS); QUINAZOLINES; THIAZOLES; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 27744549593     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.060     Document Type: Article

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