Immunological peculiarities of extremely preterm infants: A challenge for the prevention of nosocomial sepsis

Jornal de Pediatria

Volumn 81, Issue 1 SUPPL. 1, 2005, Pages

  Rego, Maria A C ^a,b   Mussi Pinhata, Marisa Márcia ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Immunity; Immunotherapy; Nosocomial infection; Premature infant

Indexed keywords

CD11B ANTIGEN; CD16 ANTIGEN; CD18 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; COLONY STIMULATING FACTOR 1; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5B; EMOLLIENT AGENT; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; G ACTIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; INTERLEUKIN 8; L SELECTIN; LEUKOTRIENE B4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PADGEM PROTEIN; UNINDEXED DRUG;

B LYMPHOCYTE; CELLULAR IMMUNITY; COMPLEMENT SYSTEM; CYTOKINE PRODUCTION; FETUS DEVELOPMENT; HOSPITAL HYGIENE; HOSPITAL INFECTION; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNOTHERAPY; INNATE IMMUNITY; MEDLINE; NATURAL KILLER CELL; NEUTROPHIL CHEMOTAXIS; PASSIVE IMMUNIZATION; PHAGOCYTE; PREMATURITY; REVIEW; SEPSIS; T LYMPHOCYTE; CROSS INFECTION; FEMALE; FETUS; IMMUNOLOGY; NEWBORN; PREGNANCY; VERY LOW BIRTH WEIGHT;

CROSS INFECTION; FEMALE; FETUS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; PREGNANCY; SEPSIS;

EID: 27744533076     PISSN: 00217557     EISSN: 00217557     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. Ferrieri P. Neonatal susceptibility and immunity to major bacterial pathogens. Rev Infect Dis. 1990;12(Suppl 4):S394-400.
2. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110:285-91.
3. Rede Brasileira de Pesquisas Neonatais. Uso antenatal de corticosteróide e evolução clínica de recém-nascidos pré-termo. J Pediatr (Rio J). 2004;80:277-84.
4. Celini MN. Epidemiologia da infecção bacteriana hospitalar na unidade de terapia intensiva neonatal do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo [dissertação]. Ribeirão Preto (SP): Universidade de São Paulo, 2003.
5. Nagata E, Brito AS, Matsuo T. Nosocomial infections in a neonatal intensive care unit: incidence and risk factors. Am J Infec Control. 2002;30:26-31.
6. Baltimore RS. Neonatal nosocomial infections. Semin Perinatol. 1998;22:25-32.
7. Abbas AK, Litchtman AH, Pober JS. General properties of immune response: cellular and molecular immunology. 3rd ed. Philadelphia: Abbas, AK; 1997. p. 4-33.
8. Sompayrac L. How the immune system works. 1st ed. Malden, MA: Blackwell Science, Inc.; 1999.
9. Cartlidge P. The epidermal barrier. Semin Neonatol. 2000;5: 273-80.
10. Seidel BM, Schulze B, Schubert S, Borte M. Oral mucosal immunocompetence in preterm infants in the first 9 months of life. Eur J Pediatr. 2000;159:789.
11. Kuitunen M, Savilahti E. Mucosal IgA, mucosal cow's milk antibodies, serum cow's milk antibodies and gastrointestinal permeability in infants. Pediatr Allergy Immunol. 1995;6:30-5.
12. Saiman L. Risk factors for hospital-acquired infections in the neonatal intensive care unit. Semin Perinatol. 2002;26:315-21.
13. Rognum TO, Thrane S, Stoltenberg L, Vege A, Brandtzaeg P. Development of intestinal mucosal immunity in fetal life and the first postnatal months. Pediatr Res. 1992;32:145-9.
14. Schelonka RL, Infante AJ. Neonatal immunology. Semin Perinatol. 1998;22:2-14.
15. Miyano A, Miyamichi T, Nakayama M, Kitajima H, Shimizu A. Differences among acute, subacute, and chronic chorioamnionitis based on levels of inflammation-associated proteins in cord blood. Pediatr Dev Pathol. 1998;1:513-21.
16. Urlichs F, Speer CP. Neutrophil function in preterm and term infants. Neo Rev. 2004;10:e417-42.
17. Roncarolo MG. Immuno responses of cord blood cells. Bone Marrow Transplant. 1998;22(Suppl 1):S55.
18. Garcia AM, Fadel SA, Cao S, Sarzotti M. T cell immunity in neonates. Immunol Res. 2000;22:177-90.
19. Trivedi HN, HayGlass KT, Gangur V, Allardice JG, Embree JE, Plummer FA. Analysis of neonatal T cell and antigen presenting cell functions. Hum Immunol. 1997;57:69-79.
20. Carr R, Huizinga TW. Low soluble FcRIII receptor demonstrates reduced neutrophil reserves in preterm neonates. Arch Dis Child Fetal Neonatal Ed. 2000;83:F160
21. Ohls RK, Li Y, Abdel-Mageed A, Buchanan G Jr, Mandell L, Christensen RD. Neutrophil pool sizes and granulocyte colony-stimulating factor production in human mid-trimester fetuses. Pediatr Res. 1995;37:806-11.
22. Lorant DE, Li W, Tabatabaei N, Carver MK, Albertine KH. P-selectin expression by endothelial cells is decreased in neonatal rats and human premature infants. Blood. 1999;94:600-9.
23. Kansas GS. Selectins and their ligands: current concepts and controversies. Blood. 1996;88:3259-87.
24. Buhrer C, Stibenz D, Graulich J, Gernhold U, Butcher EC, Dudenhausen JW, et al. Soluble L-selectin (sCD62L) umbilical cord plasma levels increase with gestational age. Pediatr Res. 1995;38:336-41.
25. Kim SK, Keeney SE, Alpard SK, Schmalstieg FC. Comparison of L-selectin and CD11b on neutrophils of adults and neonates during the first month of life. Pediatr Res. 2003;53:132-6.
26. Abughali N, Berger M, Tosi MF. Deficient total cell content of CR3 (CD11b) in neonatal neutrophils. Blood. 1994;83:1086-92.
27. Taniuchi S, Kinoshita Y, Yamamoto A, Fujiwara T, Hattori K, Hasui M, et al. Heterogeneity in F-actin polymerization of cord blood polymorphonuclear leukocytes stimulated by N-formyl-methionyl-leucyl-phenylalanine. Pediatr Int. 1999;41:37-41.
28. Wolach B, Ben Dor M, Chomsky O, Gavrieli R, Shinitzky M. Improved chemotactic ability of neonatal polymorphonuclear cells induced by mild membrane rigidification. J Leukoc Biol. 1992;51:324-8.
29. Levy O, Martin S, Eichenwald E, Ganz T, Valore E, Carroll SF, et al. Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics. 1999;104:1327-33.
30. Nupponen I, Pesonen E, Andersson S, Makela A, Turunen R, Kautiainen H, et al. Neutrophil activation in preterm infants who have respiratory distress syndrome: extracellular release of bactericidal/permeability-increasing protein in newborn infants. Pediatrics. 2002;110:36-41.
31. Driscoll MS, Thomas VL, Ramamurthy RS, Casto DT. Longitudinal evaluation of polymorphonuclear leukocyte chemiluminescence in premature infants. J Pediatr. 1990;116:429-34.
32. Drossou V, Kanakoudi F, Tzimouli V, Sarafidis K, Taparkou A, Bougiouklis D, et al. Impact of prematurity, stress and sepsis on the neutrophil respiratory burst activity of neonates. Biol Neonate. 1997;72:201-9.
33. Bjorkqvist M, Jurstrand M, Bodin L, Fredlund H, Schollin J. Defective neutrophil oxidative burst in preterm newborns on exposure to coagulase-negative staphylococci. Pediatr Res. 2004;55:966-71.
34. Kohl S, Sigouroudinia M, Engleman EG. Adhesion defects of antibody-mediated target cell binding of neonatal natural killer cells. Pediatr Res. 1999;46:755-9.
35. McDonald T, Sneed J, Valenski WR, Dockter M, Cooke R, Herrod HG. Natural killer cell activity in very low birth weight infants. Pediatr Res. 1992;31:376-80.
36. Lee SM, Suen Y, Chang L, Bruner V, Qian J, Indes J, et al. Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and upregulation of interferon-gamma, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells. Blood. 1996;88:945-54.
37. Splawski JB, Jelinek DF, Lipsky PE. Delineation of the functional capacity of human neonatal lymphocytes. J Clin Invest. 1991;87:545-53.
38. Herrod HG, Cooke RJ, Valenski WR, Herman J, Dockter ME. Evaluation of lymphocyte phenotype and phytohemagglutinin response in healthy very low birth weight infants. Clin Immunol Immunopathol. 1991;60:268-77.
39. Veber MB, Cunningham-Rundles S, Schulman M, Mandel F, Auld PA. Acute shift in immune response to microbial activators in very-low-birth-weight infants. Clin Exp Immunol. 1991;83:391-5.
40. Kameda T, Koyama M, Matsuzaki N, Taniguchi T, Saji F, Tanizawa O. Localization of three subtypes of Fc gamma receptors in human placenta by immunohistochemical analysis. Placenta. 1991;12:15-26.
41. Morell A, Sidiropoulos D, Herrmann U, Christensen KK, Christensen P, Prellner K, et al. IgG subclasses and antibodies to group B streptococci, pneumococci, and tetanus toxoid in preterm neonates after intravenous infusion of immunoglobulin to the mothers. Pediatr Res. 1986;20:933-6.
42. Nagao AT, Costa-Carvalho BT, Arslanian C, Sole D, Naspitz C, Carneiro-Sampaio MM. Placental transfer of IgG antibodies against Haemophilus influenzae type b capsular polysaccharide in Brazilian term and preterm newborns. J Trop Pediatr. 1999;45:171-3.
43. Landor M. Maternal-fetal transfer of immunoglobulins. Ann Allergy Asthma Immunol. 1995;74:279-83.
44. Hanson LA, Silfverdal SA, Korotkova M, Erling V, Strombeck L, Olcen P, et al. Immune system modulation by human milk. Adv Exp Med Biol. 2002;503:99-106.
45. Elass E, Masson M, Mazurier J, Legrand D. Lactoferrin inhibits the lipopolysaccharide-induced expression and proteoglycan-binding ability of interleukin-8 in human endothelial cells. Infect Immun. 2002;70:1860-6.
46. Lawrence RA. Milk banking: the influence of storage procedures and subsequent processing on immunologic components of human milk. Adv Nutr Res. 2001;10:389-404.
47. Edwards WH, Conner JM, Soll RF. The effect of prophylactic ointment therapy on nosocomial sepsis rates and skin integrity in infants with birth weights of 501 to 1000 g. Pediatrics. 2004;113:1195-203
48. Conner JM, Soll RF, Edwards WH. Topical ointment for preventing infection in preterm infants. Cochrane Database Syst Rev. 2004(1):CD001150.
49. Baker CJ, Melish ME, Hall RT, Casto DT, Vasan U, Givner LB. Intravenous immune globulin for the prevention of nosocomial infection in low-birth-weight neonates. The Multicenter Group for the Study of Immune Globulin in Neonates. N Engl J Med. 1992;327:213-9.
50. Fanaroff AA, Korones SB, Wright LL, Wright EC, Poland RL, Bauer CB, et al. A controlled trial of intravenous immune globulin to reduce nosocomial infections in very-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med. 1994;330:1107-13.
51. Ohlsson A, Lacy JB. Intravenous immunoglobulin for preventing infection in preterm and/or low-birth-weight infants. Cochrane Database Syst Rev. 2004;(1):CD000361.
52. Suri M, Harrison L, van de Ven C, Cairo MS. Immunotherapy in the prophylaxis and treatment of neonatal sepsis. Curr Opin Pediatr. 2003;15:155-60.
53. Chirico G, Ciardelli L, Cecchi P, De Amici M, Gasparoni A, Rondini G. Serum concentration of granulocyte colony stimulating factor in term and preterm infants. Eur J Pediatr. 1997;156:269-71.
54. Banerjea MC, Speer CP. The current role of colony-stimulating factors in prevention and treatment of neonatal sepsis. Semin Neonatol. 2002;7:335-49.
55. Carr R, Modi N, Dore C. G-CSF and GM-CSF for treating or preventing neonatal infections. Cochrane Database Syst Rev 2003;(3):CD003066.
56. Carr R, Modi N, Dore CJ, El-Rifai R, Lindo D. A randomized, controlled trial of prophylactic granulocyte-macrophage colony-stimulating factor in human newborns less than 32 weeks gestation. Pediatrics. 1999;103:796-802.
57. Kocherlakota P, La Gamma EF. Preliminary report: rhG-CSF may reduce the incidence of neonatal sepsis in prolonged preeclampsia-associated neutropenia. Pediatrics. 1998;102:1107-11.
58. Munoz FM, Englund JA. A step ahead. Infant protection through maternal immunization. Pediatr Clin North Am. 2000;47:449-63.
59. Weisman LE, Schuman RF, Lukomska E, Stinson JR, Parks O, Fischer GW. Effectiveness and pharmacokinetics of an anti-lipoteichoic acid humanized chimeric monoclonal antibody. Pediatr Res. 2001;301A.
60. Weisman LE, Mandy GT, Garcia-Prats JA, Nesin M, Schneider JH, Johnson KE. Safety and pharmacokinetics of a human chimeric anti-staphylococcal monoclonal antibody for prevention of coagulase negative staphylococcal infection in very low birth weight infants: preliminary report. Pediatr Res. 2003;315A.
61. Boyce JM, Pittet D. Guideline for Hand Hygiene in Health-Care Settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/ IDSA Hand Hygiene Task Force. Infect Control Hosp Epidemiol. 2002;23:S3-40.
62. Mussi-Pinhata MM, Nascimento SD. Neonatal nosocomial infections. J Pediatr (Rio J). 2001;77(Suppl 1):S81-96.
63. Kilbride HW. Evaluation and development of potentially better practices to prevent neonatal nosocomial bacteremia. Pediatrics. 2003;111:e504-18.