Effects of levobupivacaine and ropivacaine on rat sciatic nerve blood flow

British Journal of Anaesthesia

Volumn 95, Issue 5, 2005, Pages 696-700

  Bouaziz, H ^a   Iohom, G ^a   Estebe J P ^b   Campana, W M ^b   Myers, R R ^b  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anaesthetics local, levobupivacaine; Anaesthetics local, lidocaine; Anaesthetics local, ropivacaine; Blood, flow; Model, rat; Toxicity, nerve

Indexed keywords

ADRENALIN; LEVOBUPIVACAINE; LIDOCAINE; PLACEBO; ROPIVACAINE; SODIUM CHLORIDE;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CLINICAL PRACTICE; CONTROLLED STUDY; DOPPLER FLOWMETRY; DOSE RESPONSE; FEMALE; HISTOPATHOLOGY; ISCHEMIA; LOCAL ANESTHESIA; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

EID: 27744529939     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aei242     Document Type: Article

References (26)

1. Myers RR, Heckman HM. Effects of local anesthesia on nerve blood flow: studies using lidocaine with and without epinephrine. Anesthesiology 1989; 71: 757-62
2. Myers RR, Murakami H, Powell HC. Reduced nerve blood flow in edematous neuropathies: A biomechanical mechanism. Microvasc Res 1986; 32: 145-51
3. Myers RR, Kalichman MW, Reisner LS, Powell HC. Neurotoxicity of local anesthetics: Altered perineural permeability, edema and nerve fiber injury. Anesthesiology 1986; 64: 29-35
4. Cederholm J, Evers H, Lofstrom JB. Effect of intradermal injection of saline or a local anesthetic agent on skin blood flow - a methodological study in man. Acta Anaesthesiol Scand 1991; 35: 208-15
5. Aps C, Reynolds F. An intradermal study of the local anaesthetic and vascular effects of the isomers of bupivacaine. Br J Clin Pharmacol 1978; 6: 63-8
6. Kristensen JD, Karlsten R, Gordh T. Spinal cord blood flow after intrathecal injection of ropivacaine and bupivacaine with or without epinephrine in rats. Acta Anaesthesiol Scand 1998; 42: 685-90
7. Rundquist I, Smith QR, Michel ME, Ask P, Oberg A, Rapoport SI. Sciatic nerve blood flow measured by laser Doppler flowmetry and [14C]iodoantipyrine. Am J Physiol 1985; 248: H311-7
8. Shepard AP, Riedel GL, Kiel JW, Haumschild DJ, Maxwell LC. Evaluation of an infrared laser-Doppler blood flowmeter. Am J Physiol 1987; 252: C832-9
9. Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR. Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology 1995; 82: 1013-25
10. Dyhre H, Lang M, Wallin R, Renck H. The duration of action of bupivacaine, levobupivacaine, ropivacaine and pethidine in peripheral nerve block in the rat. Acta Anaesthesiol Scand 1997; 41: 1346-52
11. Sugimoto H, Monafo WW, Eliasson SG. Regional sciatic nerve and muscle blood flow in conscious and anesthetized rats. Am J Physiol 1986; 251: H1211-6
12. Sladky JT, Greenberg JH, Brown MJ. Regional perfusion in normal and ischemic rat sciatic nerves. Ann Neurol 1985; 17: 191-5
13. Sharbrough FW, Messick JM, Sundt TM. Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid endarterectomy. Electroencephalogr Clin Neurophysiol 1973; 34: 61-9
14. Branston NM, Symon L, Crockard HA, Pasztor E. Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp Neurol 1974; 45: 195-208
15. Popitz-Bergez FA, Leeson S, Strichartz GR, Thalhammer JG. Relation between functional deficit and intraneural local anesthetic during peripheral nerve block. Anesthesiology 1995; 83: 583-92
16. Newton DJ, Burke D, Khan F, et al. Skin blood flow changes in response to intradermal injection of bupivacaine and levobupivacaine, assessed by laser Doppler imaging. Reg Anesth Pain Med 2000; 25: 626-31
17. Newton D, McLeod G, Khan F, Belch JJF. The effect of adjuvant epinephrine concentration on the vasoactivity of the local anesthetics bupivacaine and levobupivacaine in human skin. Reg Anesth Pain Med 2004; 29: 307-11
18. Kopacz DJ, Carpenter RL, Mackey DC. Effect of ropivacaine on cutaneous capillary blood flow in pigs. Anesthesiology 1989; 71: 69-74
19. Millay DJ, Larrabee WJ, Carpenter RL. Vasoconstriction in facial plastic surgery. Arch Otolaryngol Head Neck Surg 1991; 117: 160-3
20. Nakamura K, Toda H, Kakuyama M, et al. Direct vascular effect of ropivacaine in femoral artery and vein of the dog. Acta Anaesthesiol Scand 1993; 37: 269-73
21. Burke D, Joypaul V, Fyffe Thomson M. Circumcision supplemented by dorsal penile nerve block with 0.75% ropivacaine: A complication. Reg Anesth Pain Med 2000; 25: 424-7
22. Marcus ML, Heistad DD, Eberhardt JC, et al. Regulation of total and regional spinal cord blood flow. Circ Res 1977; 41: 128-34
23. Crosby G. Local spinal cord blood flow and glucose utilization during spinal anesthesia with bupivacaine in conscious rats. Anesthesiology 1985; 63: 55-60
24. Lundborg G. Structure and function of the intraneural microvessels as related to trauma, edema formation and nerve function. J Bone Joint Surg 1975; 57A: 938-48
25. Lundborg G. Ischemic nerve injury. Experimental studies on intraneural microvascular pathophysiology and nerve function in a limb subjected to temporary circulatory arrest. Scand J Plast Reconstr Surg 1970; 6: 3-113
26. Norton S. Is behavior or morphology a more sensitive indicator of central nervous system toxicity? Environ Health Perspect 1978; 26: 21-7