The binding of human carbonic anhydrase II by functionalized folded polypeptide receptors

Chemistry and Biology

Volumn 12, Issue 11, 2005, Pages 1245-1252

  Andersson, Theresa ^a   Lundquist, Martin ^a   Dolphin, Gunnar T ^a   Enander, Karin ^b   Jonsson, Bengt Harald ^a   Nilsson, Jonas W ^a   Baltzer, Lars ^b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE II; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; CARBONIC ANHYDRASE II; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 27744519931     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2005.08.018     Document Type: Article

References (18)

1. A. Fersht Forces between molecules and binding energies Structure and Mechanism in Protein Science. 1999 W.H. Freeman and Company New York 324 348
2. A. Lombardi, J.W. Bryson, G. Ghirlanda, and W.F. DeGrado Design of a synthetic receptor for the calmodulin-binding domain of calcineurin J. Am. Chem. Soc. 119 1997 12378 12379
3. H.S. Park, Q. Lin, and A.D. Hamilton Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction Proc. Natl. Acad. Sci. USA 99 2002 5105 5109
4. K. Enander, G.T. Dolphin, L.K. Andersson, B. Liedberg, I. Lundström, and L. Baltzer Designed, folded polypeptide scaffolds that combine key biosensing events of recognition and reporting J. Org. Chem. 67 2002 3120 3123
5. L.K. Andersson, G.T. Dolphin, and L. Baltzer Multifunctional folded polypeptides from peptide synthesis and site-selective self-functionalisation - practical scaffolds in aqueous solution ChemBioChem 3 2002 741 751
6. K. Enander, G.T. Dolphin, and L. Baltzer Designed, functionalized helix-loop-helix motifs that bind human Carbonic Anhydrase II - a new class of synthetic receptor molecules J. Am. Chem. Soc. 126 2004 4464 4465
7. P.W. Taylor, and R.W. King Kinetics of complex formation between human carbonic anhydrases and aromatic sulfonamides Biochemistry 9 1970 2638 2645
8. K. Enander, G.T. Dolphin, B. Liedberg, I. Lundström, and L. Baltzer A versatile polypeptide platform for integrated recognition and reporting - affinity arrays for protein-ligand interaction analysis Chem. Eur. J. 10 2004 2375 2385
9. W.H. Miller, A.M. Dessert, and R.O. Roblin Heterocyclic sulfonamides as carbonic anhydrase inhibitors J. Am. Chem. Soc. 72 1950 4893 4896
10. S.B. Shuker, P.J. Hajduk, R.P. Meadows, and S.W. Fesik Discovering high-affinity ligands for proteins: SAR by NMR Science 274 1996 1531 1534
11. R.A. Venters, B.T. Farmer, C.A. Fierke, and L.D. Spicer Characterizing the use of perdeuteration in NMR studies of large proteins:13C,15N and 1H assignments of human carbonic anhydrase II J. Mol. Biol. 264 1996 1101 1116
12. E.A. Eriksson, T.A. Jones, and A. Liljas Refined structure of human carbonic anhydrase II at 2.0 Å resolution Proteins 4 1988 274 282
13. R.S. Alexander, D.W. Christianson, A. Jain, and G.M. Whitesides Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors J. Med. Chem. 37 1994 2100 2105
14. L.G. Mårtensson, P. Jonasson, P.O. Freskgard, M. Svensson, U. Carlsson, and B.-H. Jonsson Contribution of individual tryptophan residues to the fluorescence spectrum of native and denatured forms of human carbonic anhydrase II Biochemistry 34 1995 1011 1021
15. L.E. Kay, P. Keifer, and T. Saarinen Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity J. Am. Chem. Soc. 114 1992 10663 10665
16. F. Delaglio, S. Grzesiek, G.W. Vuister, G. Zhu, J. Pfeifer, and A. Bax NMRPipe: a multidimensional spectral processing system based on UNIX pipes J. Biomol. NMR 6 1995 277 293
17. Goddard, T.D., and Kneller, D.G. (2004). SPARKY 3 (computer program). University of California, San Francisco.
18. R. Koradi, M. Billeter, and K. Wutrich MOLMOL: A program for display and analysis of macromolecular structures J. Mol.Graphics 14 1996 51 55