Cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis: A randomized comparative study

Journal of Urology

Volumn 174, Issue 6, 2005, Pages 2235-2238

  Sairanen, Jukka ^a,g   Tammela, Teuvo L J ^b   Leppilahti, Mikael ^c   Multanen, Markku ^d   Paananen, Ilkka ^e   Lehtoranta, Kari ^f   Ruutu, Mirja ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c SEINÄJOKI CENTRAL HOSPITAL   (Finland)

^d Kymenlaakson Sairaanhoitopiiri   (Finland)

^e OULU UNIVERSITY HOSPITAL   (Finland)

^f PÄIJÄT HÄME CENTRAL HOSPITAL   (Finland)

^g Maria Hospital   (Finland)

Author keywords

Cyclosporine, pentosan sulfuric polyester, drug therapy; Cystitis, interstitial

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMINOTRANSFERASE; BCG VACCINE; BILIRUBIN; CHOLESTEROL; CIMETIDINE; CYCLOSPORIN A; DIMETHYL SULFOXIDE; HYALURONIC ACID; HYDROXYCHLOROQUINE; HYDROXYZINE; NEUROLEPTIC AGENT; PENTOSAN POLYSULFATE; TRAMADOL;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FATIGUE; FEMALE; FLUSHING; FOLLOW UP; GASTROINTESTINAL SYMPTOM; GINGIVA HYPERPLASIA; HEADACHE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INTERSTITIAL CYSTITIS; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MYALGIA; NEPHROTOXICITY; PARESTHESIA; PELVIS PAIN SYNDROME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; URINARY FREQUENCY;

EID: 27744511754     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000181808.45786.84     Document Type: Article

References (15)

1. Gillenwater, J. Y. and Wein, A. J.: Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on interstitial cystitis, National Institutes of Health, Bethesda, Maryland, August 28-29,1987. J Urol, 140: 203, 1988
2. Rovner, E., Propert, K. J., Brensinger, C., Wein, A. J., Foy, M., Kirkemo, A. et al: Treatments used in women with interstitial cystitis: the interstitial cystitis data base (ICDB) study experience. The Interstitial Cystitis Data Base Study Group. Urology, 56: 940, 2000
3. Holm-Bentzen, M., Jacobsen, F., Nerstrom, B., Lose, G., Kristensen, J. K., Pedersen, R. H. et al: A prospective double-blind clinically controlled multicenter trial of sodium pentosanpolysulfate in the treatment of interstitial cystitis and related painful bladder disease. J Urol, 138: 503, 1987
4. Mulholland, S. G., Hanno, P., Parsons, C. L., Sant, G. R. and Staskin, D. R.: Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study. Urology, 35: 552, 1990
5. Parsons, C. L., Benson, G., Childs, S. J., Hanno, P., Sant, G. R. and Webster, G.: A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate. J Urol, 150: 845, 1993
6. Sairanen, J., Forsell, T. and Ruutu, M.: Long-term outcome of patients with interstitial cystitis treated with low dose cyclosporine A. J Urol, 171: 2138, 2004
7. O'Leary, M. P., Sant, G. R., Fowler, F. J., Jr., Whitmore, K. E. and Spolarich-Kroll, J.: The interstitial cystitis symptom index and problem index. Urology, 49: 58, 1997
8. Forsell, T., Ruutu, M., Isoniemi, H., Ahonen, J. and Alfthan, O.: Cyclosporine in severe interstitial cystitis. J Urol, 155: 1591, 1996
9. Propert, K. J., Payne, C., Kusek, J. W. and Nyberg, L. M.: Pitfalls in the design of clinical trials for interstitial cystitis. Urology, 60: 742, 2002
10. Sant, G. R., Propert, K. J., Hanno, P. M., Burks, D., Culkin, D., Diokno, A. C. et al: A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. J Urol, 170: 810, 2003
11. Parsons, C. L.: Epithelial coating techniques in the treatment of interstitial cystitis. Urology, 49: 100, 1997
12. Matsuda, S. and Koyasu, S.: Mechanisms of action of cyclosporine. Immunopharmacology, 47: 119, 2000
13. Krishnaswamy, G., Kelley, J., Johnson, D., Youngberg, G., Stone, W., Huang, S. K. et al: The human mast cell: functions in physiology and disease. Front Biosci, 6: D1109, 2001
14. Christmas, T. J.: Lymphocyte sub-populations in the bladder wall in normal bladder, bacterial cystitis and interstitial cystitis. Br J Urol, 73: 508, 1994
15. Peeker, R., Enerbäck, L., Fall, M. and Aldenborg, F.: Recruitment, distribution and phenotypes of mast cells in interstitial cystitis. J Urol, 163: 1009, 2000