Smoking and HLA-DR shared epitope alleles in rheumatoid arthritis: Comment on the article by Padyukov et al [1]

Arthritis and Rheumatism

Volumn 52, Issue 11, 2005, Pages 3675-3676

  Mattey, Derek L ^a   Hutchinson, David ^b  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^b ROYAL CORNWALL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA DR ANTIGEN;

ALLELE; CIGARETTE SMOKING; DISEASE ASSOCIATION; GENETIC RISK; HIGH RISK POPULATION; HUMAN; LETTER; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SMOKING;

ARTHRITIS, RHEUMATOID; EPITOPES; GENETIC PREDISPOSITION TO DISEASE; HLA-DR ANTIGENS; PEPTIDES, CYCLIC; RHEUMATOID FACTOR; SMOKING;

EID: 27744509318     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21504     Document Type: Letter

References (5)

1. Padyukov L, Silva C, Stolt P, Alfredsson L, Klareskog L, for the Epidemiological Investigation of Rheumatoid Arthritis Study Group. A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004;50:3085-92.
2. Mattey DL, Dawes PT, Clarke S, Fisher J, Brownfield A, Thomson W, et al. Relationship among the HLA-DRB1 shared epitope, smoking, and rheumatoid factor production in rheumatoid arthritis. Arthritis Rheum 2002;47:403-7.
3. Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E. Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol 2003;171:538-41.
4. Mattey DL, Nixon NB, Hutchinson DG. Rheumatoid factor and HLA-DRB1*0401, but not cigarette smoking, are independently associated with antibodies to cyclic citrullinated peptides in rheumatoid arthritis. Rheumatology (Oxford) 2005;44 Suppl 1:i100.
5. Mattey DL. Hutchinson D, Dawes PT, Nixon NB, Clarke S, Fisher J, et al. Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus. Arthritis Rheum 2002;46:640-6.