A laboratory algorithm with homocysteine as the primary parameter reduces the cost of investigation of folate and cobalamin deficiency

Clinical Chemistry and Laboratory Medicine

Volumn 43, Issue 10, 2005, Pages 1065-1068

  Schedvin, Göran ^a   Jones, Ian ^a   Hultdin, Johan ^b   Nilsson, Torbjörn K ^a  

^a ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cost effect analysis; Cost minimisation analysis; Homocysteine; Laboratory alogrithm

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ALGORITHM; ANALYTICAL PARAMETERS; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; COST BENEFIT ANALYSIS; COST CONTROL; CYANOCOBALAMIN DEFICIENCY; FOLIC ACID DEFICIENCY; HEALTH CARE COST; HEALTH CARE PLANNING; HUMAN; INTERMETHOD COMPARISON; LABORATORY TEST; MAJOR CLINICAL STUDY; MEDICAL ASSESSMENT; MEDICAL RECORD; PRESCRIPTION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; SWEDEN;

ALGORITHMS; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; RESEARCH; SWEDEN; VITAMIN B 12;

EID: 27744487356     PISSN: 14346621     EISSN: 14346621     Source Type: Journal    
DOI: 10.1515/CCLM.2005.186     Document Type: Article

References (10)

1. Begg D, Fischer S, Dornbusch R. Economics, 6th ed. London: McGraw-Hill, 2000.
2. Pindyck RS, Rubinfeld DL, editors. Microeconomics, 6th ed. Upper Saddle River, NJ: Prentice Hall, 2005.
3. McPake B, Kumaranayake L, Normand C, editors. Health economics, an international perspective, 1st ed. London: Routledge, 2002.
4. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004;50:13-32.
5. Stabler SP, Marcell PD, Podell ER, Allen RH. Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromategraphy-mass spectrometry. Anal Biochem 1987;162: 185-96.
6. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methyl malonic acid and total homecysteine concentrations. Am J Hematol 1990;34:99-107.
7. Lökk J, Nilsson M, Norberg B, Hultdin J, Sandström H, Westman G. Shifts in B12 opinions in primary health care of Sweden. Scand J Public Health 2001;29:122-8.
8. Price CP. Evidence-based laboratory medicine: supporting decision-making. Clin Chem 2000;46:1041-50.
9. Holleland G, Schneede J, Ueland PM, Lund PK, Refsum H, Sandberg S. Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies. Clin Chem 1999;45: 189-98
10. Nallamothu BK, Fendrick AM, Rubenfire M, Saint S, Bandekar RR, Omenn GS. Potential clinical and economic effects of homocyst(e)ine lowering, Arch Intern Med 2000;160:3406-12.