Structure-activity relationships of 2α-substituted androstenedione analogs as aromatase inhibitors and their aromatization reactions

Journal of Steroid Biochemistry and Molecular Biology

Volumn 97, Issue 4, 2005, Pages 353-359

  Numazawa, Mitsuteru ^a   Handa, Wakako ^a   Hasegawa, Chie ^a   Takahashi, Madoka ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

2 Alkyl androgens; 2 Halogeno androgens; Aromatase inhibitor; Aromatization; Gas chromatography mass spectrometry; Structure activity relationship

Indexed keywords

ANDROSTENEDIONE DERIVATIVE; AROMATASE INHIBITOR; BROMINE; CHLORINE; FLUORINE; STEROID;

AROMATIZATION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME INACTIVATION; ENZYME SUBSTRATE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MICROSOME; PLACENTA; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANDROSTENEDIONE; AROMATASE INHIBITORS; BINDING SITES; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MASS SPECTROMETRY; MICROSOMES; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OXYGEN; PLACENTA; PROTEIN BINDING; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744476294     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.06.029     Document Type: Article

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