Black walnut extract-induced laminitis in horses is associated with heterogeneous dysfunction of the laminar microvasculature

Equine Veterinary Journal

Volumn 37, Issue 6, 2005, Pages 546-551

  Peroni, J F ^a   Harrison, W E ^a   Moore, J N ^a   Graves, J E ^a   Lewis, S J ^a   Krunkosky, T M ^a   Robertson, T P ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Black walnut; Horse; Laminar; Laminitis; Microvessels

Indexed keywords

EQUIDAE; EQUUS CABALLUS; JUGLANS; JUGLANS NIGRA;

EID: 27744458570     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516405775314781     Document Type: Article

References (20)

1. Adair, H.S., Goble, D.O., Schmidhammer, J.L. and Shires, G.M. (2000) Laminar microvascular flow, measured by means of laser Doppler flowmetry, during the prodromal stages of black walnut-induced laminitis in horses. Am. J. vet. Res. 61, 862-868.
2. Allen, D., Clark, E.S., Moore, J.N. and Prasse, K.W. (1990) Evaluation of equine digital Starling forces and hemodynamics during early laminitis. Am. J. vet. Res. 51, 1930-1934.
3. Anon (2001) Report of the AVMA panel on euthanasia. J. Am. vet. med. Ass. 218, 669-696.
4. Bailey, S.R. and Elliott, J. (1998) Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for pathogenesis of acute laminitis. Equine vet. J. 30, 124-130.
5. Baxter, G.M., Laskey, R.E., Tackett, R.L., Moore, J.N. and Allen, D. (1989) In vitro reactivity of digital arteries and veins and to vasoconstrictive mediators in healthy horses and in horses with early laminitis. Am. J. vet. Res. 50, 508-517.
6. Curro, F.A., Greenberg, S., Verbeuren, T.J. and Vanhoutte, P.M. (1978) Interaction between alpha adrenergic and serotonergic activation of canine saphenous veins. J. Pharmacol. expt. Ther. 207, 936-949.
7. Eaton, S.A., Allen, D., Eades, S.C. and Schneider, D.A. (1995) Digital Starling forces and hemodynamics during early laminitis induced by an aqueous extract of black walnut (Juglans nigra) in horses. Am. J. vet. Res. 56, 1338-1344.
8. Elliott, J. (1997) Alpha-adrenoceptors in equine digital veins: Evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction. J. vet. Pharmacol. Therap. 20, 308-317.
9. Galey, F.D., Twardock, A.R., Goetz, T.E., Schaeffer, D.J., Hall, J.O. and Beasley, V.R. (1990) Gamma scintigraphic analysis of the distribution of perfusion of blood in the equine foot during black walnut (Juglans nigra)-induced laminitis. Am. J. vet. Res. 51, 688-695.
10. Hood, D.M. (1999) The pathophysiology of developmental and acute laminitis. Vet. Clin. N. Am.: Equine Pract. 15, 321-334.
11. Hood, D.M., Amoss, M.S. and Grosenbaugh, D.A. (1990) Equine laminitis: a potential model of Raynaud's phenomenon. Angiol. 41, 270-277.
12. Hood, D.M., Grosenbaugh, D.A., Mostafa, M.B., Morgan, S.J. and Thomas, B.C. (1993) The role of vascular mechanisms in the development of acute equine laminitis. J. vet. Int. Med. 7, 228-234.
13. Leach, R.M., Twort, C.H., Cameron, I.R. and Ward, J.P. (1992) A comparison of the pharmacological and mechanical properties in vitro of large and small pulmonary arteries of the rat. Clin. Sci. (Lond.) 82, 55-62.
14. Mulvany, M.J. and Halpern, W. (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41, 19-26.
15. Obel, N. (1948) Studies on the Histopathology of Acute Laminits, Almqvist and Wiksells Boktryckteri AK, Uppsala, Sweden. pp 1-50.
16. Robinson, N.E., Scott, J.B., Dabney, J.M. and Jones, G.A. (1976) Digital vascular responses and permeability in equine alimentary laminitis. Am. J. vet. Res. 37, 1171-1176.
17. Schneider, D.A., Parks, A.H., Eades, S.C. and Tackett, R.L. (1999) Palmar digital vessel relaxation in healthy horses and in horses given carbohydrate. Am. J. vet. Res. 60, 233-239.
18. Wallenstein, S., Zucker, C.L. and Fleiss, J.L. (1980) Some statistical methods useful in circulation research. Circ. Res. 47, 1-9.
19. Winer, B.J. (1971) Design and analysis of factorial experiments: completely randomized design. In: Statistical Principles of Experimental Design, McGraw-Hill, New York. pp 752-809.
20. Zellers, T.M. and Vanhoutte, P.M. (1989) Heterogeneity of endothelium-dependent and independent responses among large and small porcine pulmonary arteries. Pulm. Pharmacol. 2, 201-208.