Pathogenesis of Haemophilic Synovitis and Arthropathy

The Haemophilic Joints: New Perspectives

Volumn , Issue , 2007, Pages 12-16

  Roosendaal, G ^a   Lafeber, F P J G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Haemophilia; Haemophilic arthropathy; Haemophilic synovitis; Pathogenesis; X chromosome linked disease

Indexed keywords

EID: 27744456809     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470986929.ch2     Document Type: Chapter

References (29)

1. Creveld van S, Hoedemaker PJ, Kingma MJ, Wagenvoort CA. Degeneration of joints in haemophiliacs under treatment by modern methods. J Bone Joint Surg Br 1971; 53-B: 296-302.
2. Madhok R, Bennett D, Sturrock RD, Forbes CD. Mechanisms of joint damage in an experimental model of haemophilic arthritis. Arthritis Rheum 1988; 31: 1148-55.
3. Stein H, Duthie RB. The pathogenesis of chronic haemophilic arthropathy. J Bone Joint Surg Br 1981; 63-B: 601-9.
4. Madhok R, York J, Sturrock RD. Haemophilic arthritis. Ann Rheum Dis 1991; 50: 588-91.
5. Hoaglund FT. Experimental hemarthrosis: the response of canine knees to injections of autologous blood. J Bone Joint Surg Am 1967; 49-A: 285-98.
6. Zeman DH, Roberts ED, Shoji H, Miwa T. Experimental haemarthrosis in rhesus monkeys: morphometric, biochemical and metabolic analyses. J Comp Pathol 1991; 104: 129-39.
7. Wolf CR, Mankin HJ. The effect of experimental hemarthrosis on articular cartilage of rabbit knee joints. J Bone Joint Surg Am 1965; 47-A: 1203-10.
8. Roy S, Ghadially FN. Pathology of experimental haemarthrosis. Ann Rheum Dis 1966; 25: 402-15.
9. Fischer K, van der Bom JG, Mauser-Bunschoten EP etal. The effects of postponing prophylactic treatment on long-term outcome in patients with severe hemophilia. Blood 2002; 99: 2337-41.
10. van den Berg HM, Fischer K, Mauser-Bunschoten EP et al. Longterm outcome of individualised prophylactic treatment of children with severe haemophilia. Br J Haematol 2001; 112: 561-5.
11. Fischer K, van der Bom JG, Mauser-Bunschoten EP et al. Changes in treatment strategies for severe haemophilia over the last 3 decades: effects on clotting factor consumption and arthropathy. Haemophilia 2001; 7: 446-52.
12. Mainardi CL, Levine PH, Werb Z, Harris ED. Proliferative synovitis in hemophilia: biochemical and morphologic observations. Arthritis Rheum 1978; 21: 137-44.
13. Pelletier J-P, Martel-Pelletier J, Ghandur-Mnaymneh L, Howell DS, Frederick Woessner J. Role of synovial membrane inflammation in cartilage matrix breakdown in the Pond-Nuki model of osteoarthritis. Arthritis Rheum 1985; 28: 554-61.
14. Abrahams TG, Pavlov H, Bansal M, Bullough P. Concentric joints space narrowing of the hip associated with hemosiderotic synovitis (HS) including pigmented villonodular synovitis (PVNS). Skeletal Radiol 1988; 17: 37-45.
15. France MP, Gupta SK. Non-haemophilic hemosiderotic synovitis of the shoulder: a case report. Clin Orthop 1991; 262: 132-6.
16. Morris CJ, Blake DR, Wainwright AC, Steven MM. Relationship between iron deposits and tissue damage in the synovium: an ultra structural study. Ann Rheum Dis 1986; 45: 21-6.
17. Blake DR, Gallagher PJ, Potter AR, Bell MJ, Bacon PA. The effect of synovial iron on the progression of rheumatoid disease: a histologic assessment of patients with early rheumatoid synovitis. Arthritis Rheum 1984; 27: 495-501.
18. Roosendaal G, Vianen ME, Wenting MJG et al. Iron deposits and catabolic properties of synovial tissue from patients with haemophilia. J Bone Joint Surg Br 1998; 80-B: 540-5.
19. Roosendaal G, van Rinsum AC, Vianen ME et al. Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease. Histopathology 1999; 34: 144-53.
20. Roosendaal G, Vianen ME, van den Berg HM, Lafeber FP, Bijlsma JW. Cartilage damage as a result of hemarthrosis in a human in vitro model. J Rheumatol 1997; 24: 1350-4.
21. Roosendaal G, Vianen ME, Marx JJM et al. Blood-induced joint damage: a human in vitro study. Arthritis Rheum 1999; 42: 1025-32.
22. Lafeber FP, van der Kraan PM, van Roy JL, Huber Bruning O, Bijlsma JW. Articular cartilage explant culture: an appropriate in vitro system to compare osteoarthritic and normal human cartilage. Connect Tissue Res 1993; 29: 287-99.
23. Niibayashi H, Shimizu K, Suzuki K et al. Proteoglycan degradation in hemarthrosis: intra-articular, autologous blood injection in rat knees. Acta Orthop Scand 1995; 66: 73-9.
24. Bates EJ, Lowther DA, Handley CJ. Oxygen free-radicals mediate an inhibition of proteoglycan synthesis in cultured articular cartilage. Ann Rheum Dis 1984; 43: 462-9.
25. Burkhardt H, Schwingel M, Menninger H, Macartney HW, Tschesche H. Oxygen radicals as effectors of cartilage destruction: direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes. Arthritis Rheum 1986; 29: 379-87.
26. Roosendaal G, Tekoppele JM, Vianen ME et al. Blood-induced joint damage: a canine in vivo study. Arthritis Rheum 1999; 42: 1033-9.
27. Roosendaal G, Tekoppele JM, Vianen ME et al. Articular cartilage is more susceptible to blood-induced cartilage damage at young age than old age. J Rheumatol 2000; 27: 1740-4.
28. Convery FR, Woo SL, Akeson WH et al. Experimental hemarthro- sis in the knee of the mature canine. Arthritis Rheum 1976; 19: 59-67.
29. Parsons JR, Zingler BM, McKeon JJ. Mechanical and histological studies of acute joint hemorrhage. Orthopedics 1987; 10: 1019-26.