Stability of heparin and physical compatibility of heparin/antibiotic solutions in concentrations appropriate for antibiotic lock therapy

Journal of Antimicrobial Chemotherapy

Volumn 56, Issue 5, 2005, Pages 951-953

  Robinson, Joan L ^a,b   Tawfik, Gerda ^b   Saxinger, Lynora ^a   Stang, Linda ^a   Etches, Wai ^a   Lee, Bonita ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b STOLLERY CHILDREN S HOSPITAL   (Canada)

Author keywords

Ampicillin; Cefazolin; Heparin; Piperacillin; Stability; Vancomycin

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CEFAZOLIN; HEPARIN; PIPERACILLIN; VANCOMYCIN;

ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; OUTCOMES RESEARCH; PARTIAL THROMBOPLASTIN TIME; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STABILITY;

AMPICILLIN; ANTI-BACTERIAL AGENTS; CEFAZOLIN; DRUG COMBINATIONS; DRUG INCOMPATIBILITY; DRUG INTERACTIONS; DRUG STABILITY; HEPARIN; HUMANS; PARTIAL THROMBOPLASTIN TIME; PIPERACILLIN; VANCOMYCIN;

EID: 27744454558     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dki311     Document Type: Article

References (9)

1. Mermel LA, Farr BM, Sheretz RJ et al. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis 2001; 32: 1249-72.
2. de Neef M, Heijboer H, van Woensel JB et al. The efficacy of heparinization in prolonging patency of arterial and central venous catheters in children: A randomized double-blind trial. Pediatr Hematol Oncol 2002; 19: 553-60.
3. Jacobs J, Kletter D, Superstine E et al. Intravenous infusion of heparin and penicillins. J Clin Pathol 1973; 26: 742-6.
4. Henrickson KJ, Powell KR, Schwartz C. A dilute solution of vancomycin and heparin retains antibacterial and anticoagulant activities. J Infect Dis 1988; 157: 600-1.
5. Saxinger L, Williams KE, Lyon M et al. Stability of antibiotics in heparin at 37°C: Towards antibiotic locks for central venous catheter related infections. In: Programs and Abstracts of the Thirty-ninth Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, 1999. Abstract 626, American Society for Microbiology, Washington, DC, USA.
6. Vercaigne LM, Sitar DS, Penner SB et al. Antibiotic-heparin lock: In vitro antibiotic stability combined with heparin in a central venous catheter. Pharmacotherapy 2000; 20: 394-9.
7. Najari A, Rusho WJ. Compatibility of commonly used bone marrow transplant drugs during Y site delivery. Am J Health Syst Pharm 1997; 54: 181-4.
8. Segarra-Newnham M, Martin-Cooper EM. Antibiotic lock technique: A review of the literature. Ann Pharmacother 2005; 39: 311-8.
9. Trissel LA. Handbook on Injectable Drugs. 12th edn. Bethesda, MD: American Society of Health System Pharmacists Inc., 2003.