Value of new prostate cancer markers: Alpha méthylacyl CoA racemase (P504S) and p63;Intérêt des nouveaux marqueurs histologiques du cancer de prostate: Alpha méthylacyl CoA racemase (P504S) et p63

Progres en Urologie

Volumn 15, Issue 4, 2005, Pages 611-615

  Molinié, Vincent ^a   Hervé, Jean Marie ^b   Lugagne, Pierre Marie ^b   Yonneau, Laurent ^b   Ellard, Stéphane ^b   Lebret, Thierry ^b   Botto, Henry ^b  

^a SAINT JOSEPH HOSPITAL   (France)

^b FOCH HOSPITAL   (France)

Author keywords

A m thylacyl CoA racemase; Diagnosis; p63; Prostate cancer

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; ALPHA-METHYLACYL-COA RACEMASE; CKAP4 PROTEIN, HUMAN; ISOMERASE; MEMBRANE PROTEIN;

CHEMISTRY; HUMAN; MALE; PATHOLOGY; PROSTATE TUMOR; REVIEW;

HUMANS; MALE; MEMBRANE PROTEINS; PROSTATIC NEOPLASMS; RACEMASES AND EPIMERASES;

EID: 27644578474     PISSN: 11667087     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. VILLERS A., POMMIER P., BATAILLARD A., ET AL. : Summary of the Standards, Options and Recommendations for the management of patients with nonmetastatic prostate cancer (2001). Br. J. Cancer, 2003 ; 89 : S50-8.
2. MOLINIE V. : Néoplasies intra épithéliales prostatiques. Ann. Pathol., 2001; 21 : 245-254.
3. OLIAI B.R., KAHANE H., EPSTEIN J.I. :Can basal cells be seen in adenocarcinoma of the prostate ? an immunohistochemical study using high molecular weight cytokeratin (clone 34betaE12) antibody. Am. J. Surg. Pathol., 2002 ; 26 : 1151-1160.
4. ABRAHAMS N.A., ORMSBY A.H., BRAINARD J. Validation of cytokeratin 5/6 as an effective substitute for keratin 903 in the differentiation of benign from malignant glands in prostate needle biopsies. Histopathology, 2002 ; 41 : 35-41.
5. GOWN A.M., VOGEL A.M. : Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues. Am. J. Pathol., 1984 ; 114 : 309-321.
6. BRAWER M.K., PEEHL D.M., STAMEY T.A., BOSTWICK D.G. : Keratin immunoreactivity in the benign and neoplastic human prostate. Cancer Res., 1985 ; 45 : 3663-3667.
7. HEDRICK L., EPSTEIN J.I. : Use of keratin 903 as an adjunct in the diagnosis of prostate carcinoma. Am. J. Surg. Pathol., 1989 ; 13 : 389-396.
8. WOJNO K.J., EPSTEIN J.I. : The utility of basal cell-specific anti-cytokeratin antibody (34 beta E12) in the diagnosis of prostate cancer. A review of 228 cases. Am. J. Surg. Pathol., 1995 ; 19 : 251-260.
9. CHU P.G., WEISS L.M. : Keratin expression in human tissues and neoplasms. Histopathology, 2002 ; 40 : 403-439.
10. SHAH R.B., ZHOU M., LEBLANC M., SNYDER M., RUBIN M.A. : Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer. Am. J. Surg. Pathol., 2002 ; 26 : 1161-1168.
11. SIGNORETTI S., WALTREGNY D., DILKS J., ISAAC B., LIN D., GARRAWAY L., YANG A., MONTIRONI R., MCKEON F., LODA M. p63 is a prostate basal cell marker and is required for prostate development. Am. J. Pathol., 2000 ; 157 : 1769-1775.
12. YANG A., MCKEON F. : P63 and P73: P53 mimics, menaces and more. Nat. Rev. Mol. Cell Biol., 2000 ; 1 : 199-207.
13. PARSONS J.K., GAGE W.R., NELSON W.G., DE MARZO A.M. : p63 protein expression is rare in prostate adenocarcinoma: implications for cancer diagnosis and carcinogenesis. Urology, 2001 ; 58 : 619-624.
14. RUBIN M.A., ZHOU M., DHANASEKARAN S.M., VARAMBALLY S., BARETTE T.R., SANDA M.G., PIENTA K.J., GHOSH D., CHINNAIYAN A.M. alpha-méthylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. Jama, 2002 ; 287 : 1662-1670.
15. MOLINIE V.H.J., LEBRET T., LUGAGNE-DELPON P.M., SAPORTA F., YONNEAU L., BOTTO H., BAGLIN A.C. : Apport d'un cocktail d'anticorps (p63 + p504s) dans le diagnostic de cancer de prostate. Ann. Pathol. 2004.
16. EVANS A.J. : Alpha-méthylacyl CoA racemase (P504S): overview and potential uses in diagnostic pathology as applied to prostate needle biopsies. J. Clin. Pathol., 2003 ; 56 : 892-897.
17. XU J., STOLK J.A., ZHANG X., SILVA S.J., HOUGHTON R.L., MATSUMURA M., VEDVICK T.S., LESLIE K.B., BADARO R., REED S.G. Identification of differentially expressed genes in human prostate cancer using subtraction and microarray. Cancer Res., 2000 ; 60 : 1677-1682.
18. WELSH J.B., SAPINOSO L.M., SU A.I., KERN S.G., WANG-RODRIGUEZ J., MOSKALUL C.A., FRIERSON H.F., HAMPTON G.M. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res., 2001 ; 61 : 5974-5977.
19. LUO J., ZHA S., GAGE W.R., DUDNN T.A., HICKS J.L., BENNET C.J., EWING C.M., PLATZ E.A., FERDINANDUSSE S., WANDERS R.J., TRENT J.M., ISAACS W.B., DE MARZO A.M. Alpha-méthylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res., 2002 ; 62 : 2220-2226.
20. SCHMITZ W., ALBERS C., FINGERHUT R., CONZELMANN E. : Purification and characterization of an alpha-méthylacyl-CoA racemase from human liver. Eur. J. Biochem., 1995 ; 231 : 815-822.
21. ZHENG S.L., CHANG B.L., FAITH D.A., JOHNSON J.R., ISAACS S.D., HAWKINS G.A., TURNER A., WILEY K.E., BLEECKER E;R., WALSH P.C., MEYERS D.A., ISAACS W.B., XU J. Sequence variants of alpha-méthylacyl-CoA racemase are associated with prostate cancer risk. Cancer Res., 2002 ; 62 : 6485-6488.
22. AMERY L., FRANSEN M., DE NYS K., MANNAERTS G.P., VAN VELDHOVEN P.P. : Mitochondrial and peroxisomal targeting of 2-methy-lacyl-CoA racemase in humans. J. Lipid. Res., 2000 ; 41 : 1752-1759.
23. VAN VELDHOVEN P.P., CROES K., CASTEELS M., MANNAERTS G.P.: 2-methylacyl racemase: a coupled assay based on the use of pristanoyl-CoA oxidase/peroxidase and reinvestigation of its subcellular distribution in rat and human liver. Biochim. Biophys. Acta, 1997 ; 1347 : 62-68.
24. FERDINANDUSSE S., DENIS S., CLAYTON PT, GRAHAM A., REES J.E., ALLEN J.T., McLEAN B.N., BROWN A.Y., VREKEN P., WATERHAM H.R., WANDERS R.J. Mutations in the gene encoding peroxisomal alpha-méthylacyl-CoA racemase cause adult-onset sensory motor neuropathy. Nat. Genet., 2000 ; 24 : 188-191.
25. LEAV I., McNEAL J.E., HO S.M., JIANG Z. : Alpha-méthylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone. Hum. Pathol., 2003 ; 34: 228-233.
26. TRETIAKOVA M.S., SAHOO S., TAKAHASHI M., TURKYILMAZ M., VOGELZANG N., LIN F., KRAUSZ T., TEH BIN T., YANG X. Expression of alpha-méthylacyl-CoA racemase in papillary renal cell carcinoma. Am. J. Surg. Pathol., 2004 ; 28 : 69-76.
27. JIANG Z., FANGER G.R., BANNER B.F., WODA B.A., ALGATE P., DRESSER K., XU J., REED S.G., ROCK K.L., CHU P.G. A dietary enzyme: alpha-méthylacyl-CoA racemase/P504S is overexpressed in colon carcinoma. Cancer Detect. Prev., 2003 ; 27 : 422-426.
28. JIANG Z., WU C.L., WODA B.A., DRESSER K., XU J., FANGER G., YANG X. P504S/alpha-méthylacyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am. J. Surg. Pathol., 2002 ; 26 : 1169-1174.
29. BEACH R., GOWN A.M., DE PERALTA-VENTURINA M.N., FOLPE A.L., YAZIJI H., SALLES P.G., GRIGNON D.J., FANGER G.R., AMIN M.B. : P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies. Am. J. Surg. Pathol., 2002 ; 26 : 1588-1596.
30. JIANG Z., FANGER G.R., WODA B.A., BANNER B., ALGATE P., DRESSER K., XU J., CHU P. Expression of alpha-méthylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: astudy of 761 cases. Hum. Pathol., 2003 ; 34 : 792-796.
31. JIANG Z., WODA B.A., ROCK K.L., XU Y., SAVAS K., KHAN A., PIHAN G., CAI F., BABCOCOOK J., RATHANASWAMI P., REED S., XU J., FANGE G. P504S : a new molecular marker for the detection of prostate carcinoma. Am. J. Surg. Pathol., 2001 ; 25 : 1397-1404.
32. JIANG Z., ICZKOWSKI K.A., WODA B.A., TRETIAKOVA M., YANG X.J. : P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Am. J. Clin. Pathol., 2004 ; 121 : 99-107.
33. ZHOU M., CHINNAIYAN A.M., KLEER C.G., LUCAS P.C., RUBIN M.A.: Alpha-méthylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions. Am. J. Surg. Pathol., 2002 ; 26 : 926-931.
34. YANG X.J., WU C.L., WODA B.A., DRESSER K., TRETIAKOVA M., FANGER G., JIANG Z. Expression of alpha-méthylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate. Am. J. Surg. Pathol., 2002 ; 26 : 921-925.
35. ICZKOWSKI K.A., CHEN H.M., YANG X.J., BEACH R.A. : Prostate cancer diagnosed after initial biopsy with atypical small acinar proliferation suspicious for malignancy is similar to cancer found on initial biopsy. Urology, 2002 ; 60 : 851-854.
36. KUNJU L.P., RUBIN M.A., CHINNAIYAN A.M., SHAH R.B. : Diagnostic usefulness of monoclonal antibody P504S in the workup of atypical prostatic glandular proliferations. Am. J. Clin. Pathol., 2003 ; 120 : 737-745.
37. NELSON W.G., DE MARZO A.M., ISAACS W.B. : Prostate cancer. N. Engl. J. Med., 2003 ; 349 : 366-381.
38. MOLINIE V., FROMONT G., SIBONY M., VIEILLEFOND A., VASSILIU V., COCHAND-PRIOLLET B., HERVE J.M., LEBRET T., BAGLIN A.C. : Diagnostic utility of a p63/alpha-methyl-CoA-racemase (p504s) cocktail in atypical foci in the prostate. Mod. Pathol., 2004 ; 17 : 1180-1190.