Alternative delivery of insulin via eye drops

Diabetes Technology and Therapeutics

Volumn 7, Issue 5, 2005, Pages 695-698

  Xuan, B ^a,b   McClellan, D A ^a   Moore, R ^a   Chiou, G C Y ^b,c  

^a Brazos Valley Family Practice Residency   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

^c TEXAS A AND M UNIVERSITY SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EYE DROPS; FUSIDIC ACID; GLYCOCHOLIC ACID; INSULIN; KETAMINE; XYLAZINE;

ACIDITY; ALKALINITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GLUCOSE MONITORING; DEVICE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG INSTILLATION; GLUCOSE BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ABSORPTION; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS; DRUG INTERACTIONS; FEMALE; FUSIDIC ACID; GLYCOCHOLIC ACID; HUMANS; INSULIN; OPHTHALMIC SOLUTIONS; RABBITS;

EID: 27644572827     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/dia.2005.7.695     Document Type: Article

References (7)

1. Chiou GCY, Chuang CY, Chang MS: Reduction of blood glucose concentration with insulin eye drops. Diabetes Care 1988;11:750-751.
2. Chiou GCY, Chuang CY, Chang MS: Systemic delivery of insulin through eyes to lower the glucose concentration. J Ocul Pharmacol 1989;5:81-91.
3. Chiou GCY, Chuang CY: Improvement of systemic absorption of insulin through eyes with absorption enhancers. J Pharm Sci 1989;78:815-818.
4. Chiou GCY, Shen ZF, Zheng YQ: Adjustment of blood sugar levels with insulin and glucagon eye drops in nomal and diabetic rabbits. J Ocul Pharmacol 1990;6:233-241.
5. Chiou GCY, Li BHP: Chronic systemic delivery of insulin through the ocular route. J Ocul Pharmacol 1993;9:85-90.
6. Schwade ND, Abritton FD, Liu SXL, Chiou GCY: Comparison of systemic absorption with punctum sealed and via normal eye with punctum opened. Drug Deliv 1993;1:139-142.
7. Liu SXL, Chiou GCY: Feasibility of insulin eye drops for human use. J Ocul Pharmacol 1994;10:587-590.