A cancer-specific transcriptional signature in human neoplasia

Journal of Clinical Investigation

Volumn 115, Issue 11, 2005, Pages 3015-3025

  Nicassio, Francesco ^a,b   Bianchi, Fabrizio ^a,b   Capra, Maria ^a,b   Vecchi, Manuela ^a,b   Confalonieri, Stefano ^a,b   Bianchi, Marco ^a   Pajalunga, Deborah ^c   Crescenzi, Marco ^c   Bonapace, Ian Marc ^a,b,d   Di Fiore, Pier Paolo ^a,b,e  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d UNIVERSITY OF INSUBRIA   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

E1A PROTEIN; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL TRANSFORMATION; COLON ADENOCARCINOMA; COLON CANCER; CONTROLLED STUDY; EMBRYO; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE CELL REENTRY INDUCED GENE; UPREGULATION; VALIDATION PROCESS;

ADENOVIRUS E1A PROTEINS; ANIMALS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HT29 CELLS; HUMANS; MICE; MUSCLE FIBERS; NEOPLASMS; NIH 3T3 CELLS; RNA, MESSENGER;

EID: 27644572680     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI24862     Document Type: Article

References (51)

1. Ramaswamy, S., et al. 2001. Multiclass cancer diagnosis using tumor gene expression signatures. Proc. Natl. Acad. Sci. U. S. A. 98:15149-15154.
2. Ramaswamy, S., and Golub, T.R. 2002. DNA microarrays in clinical oncology. J. Clin. Oncol. 20:1932-1941.
3. Iafrate, A.J., et al. 2004. Detection of large-scale variation in the human genome. Nat. Genet. 36:949-951.
4. Jones, C., et al. 2004. Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes. Clin. Cancer Res. 10:5988-5997.
5. Pollack, J.R., et al. 2002. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc. Natl. Acad. Sci. U. S. A. 99:12963-12968.
6. Andres, V., and Walsh, K. 1996. Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis. J. Cell Biol. 132:657-666.
7. Tiainen, M., et al. 1996. Terminally differentiated skeletal myotubes are not confined to G0 but can enter G1 upon growth factor stimulation. Cell Growth Differ. 7:1039-1050.
8. Pajalunga, D., et al. 1999. E2F activates late-G1 events but cannot replace E1A in inducing S phase in terminally differentiated skeletal muscle cells. Oncogene. 18:5054-5062.
9. Huh, M.S., Parker, M.H., Scime, A., Parks, R., and Rudnicki, M.A. 2004. Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J. Cell Biol. 166:865-876.
10. Camarda, G., et al. 2004. A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells. J. Cell Biol. 167:417-423.
11. Deng, C., Zhang, P., Harper, J.W., Elledge, S.J., and Leder, P. 1995. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82:675-684.
12. Sage, J., Miller, A.L., Perez-Mancera, P.A., Wysocki, J.M., and Jacks, T. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424:223-228.
13. Kirshenbaum, L.A., and Schneider, M.D. 1995. Adenovirus E1A represses cardiac gene transcription and reactivates DNA synthesis in ventricular myocytes, via alternative pocket protein- and p300-binding domains. J. Biol. Chem. 270:7791-7794.
14. Crescenzi, M., Soddu, S., and Tato, F. 1995. Mitotic cycle reactivation in terminally differentiated cells by adenovirus infection. J. Cell. Physiol. 162:26-35.
15. Whyte, P., et al. 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature. 334:124-129.
16. Bandara, L.R., and La Thangue, N.B. 1991. Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor. Nature. 351:494-497.
17. Howe, J.A., Mymryk, J.S., Egan, C., Branton, P.E., and Bayley, S.T. 1990. Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis. Proc. Natl. Acad. Sci. U. S. A. 87:5883-5887.
18. Guilhot, C., Benchaibi, M., Flechon, J.E., and Samarut, J. 1993. The 12S adenoviral E1A protein immortalizes avian cells and interacts with the avian RB product. Oncogene. 8:619-624.
19. Faha, B., Harlow, E., and Lees, E. 1993. The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J. Virol. 67:2456-2465.
20. Shi, Y., et al. 2003. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature. 422:735-738.
21. Deleu, L., Shellard, S., Alevizopoulos, K., Amati, B., and Land, H. 2001. Recruitment of TRRAP required for oncogenic transformation by E1A. Oncogene. 20:8270-8275.
22. Fuchs, M., et al. 2001. The p400 complex is an essential E1A transformation target. Cell. 106:297-307.
23. Ghosh, M.K., and Harter, M.L. 2003. A viral mechanism for remodeling chromatin structure in G0 cells. Mol. Cell. 12:255-260.
24. Alevizopoulos, K., Catarin, B., Vlach, J., and Amati, B. 1998. A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1). EMBO J. 17:5987-5997.
25. Reid, J.L., Bannister, A.J., Zegerman, P., Martinez-Balbas, M.A., and Kouzarides, T. 1998. E1A directly binds and regulates the P/CAF acetyltransferase. EMBO J. 17:4469-4477.
26. Dorsman, J.C., et al. 1995. The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains. J. Virol. 69:2962-2967.
27. Goodman, R.H., and Smolik, S. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14:1553-1577.
28. Babiss, L.E., et al. 1986. Mutations in the E1a gene of adenovirus type 5 alter the tumorigenic properties of transformed cloned rat embryo fibroblast cells. Proc. Natl. Acad. Sci. U. S. A. 83:2167-2171.
29. Subramanian, T., Kuppuswamy, M., Nasr, R.J., and Chinnadurai, G. 1988. An N-terminal region of adenovirus E1a essential for cell transformation and induction of an epithelial cell growth factor. Oncogene. 2:105-112.
30. Chen, D., et al. 2004. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell. 5:539-551.
31. Classon, M., and Harlow, E. 2002. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer. 2:910-917.
32. MacPherson, D., et al. 2004. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 18:1681-1694.
33. Puri, P.L., et al. 1997. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell. 1:35-45.
34. Braun, T., Bober, E., and Arnold, H.H. 1992. Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5. Genes Dev. 6:888-902.
35. Tiainen, M., Spitkovsky, D., Jansen-Durr, P., Sacchi, A., and Crescenzi, M. 1996. Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms. Mol. Cell. Biol. 16:5302-5312.
36. Caruso, M., Martetti, F., Giordano, A., and Felsani, A. 1993. Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein. Oncogene. 8:267-278.
37. Bagchi, S., Raychaudhuri, P., and Nevins, J.R. 1990. Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription-factor: a novel mechanism for E1A trans-activation. Cell. 62:659-669.
38. Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J., and Berns, A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14:994-1004.
39. Vernell, R., Helin, K., and Muller, H. 2003. Identification of target genes of the p16INK4A-pRB-E2F pathway. J. Biol. Chem. 278:46124-46137.
40. Muller, H., et al. 2001. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15:267-285.
41. Ramaswamy, S., Ross, K.N., Lander, E.S., and Golub, T.R. 2003. A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33:49-54.
42. van't Veer, L.J., et al. 2002. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 415:530-536.
43. Kraus, M.H., Popescu, N.C., Amsbaugh, S.C., and King, C.R. 1987. Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 6:605-610.
44. van de Vijver, M.J., et al. 2002. A gene-expression signature as a predictor of survival in breast cancer. N. Eng. J. Med. 347:1999-2009.
45. Spartz, A.K., Herman, R.K., and Shaw, J.E. 2004. SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice. Mol. Cell. Biol. 24:6811-6823.
46. Spike, C.A., Shaw, J.E., and Herman, R.K. 2001. Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans. Mol. Cell. Biol. 21:4985-4995.
47. Isono, K., et al. 2001. Molecular cloning, genetic mapping, and expression of the mouse Sf3b1 (SAP155) gene for the U2 snRNP component of spliceosome. Mamm. Genome. 12:192-198.
48. Charrasse, S., Lorca, T., Doree, M., and Larroque, C. 2000. The Xenopus XMAP215 and its human homologue TOG proteins interact with cyclin B1 to target p34cdc2 to microtubules during mitosis. Exp. Cell Res. 254:249-256.
49. Gergely, F., Draviam, V.M., and Raff, J.W. 2003. The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev. 17:336-341.
50. Soond, S.M., Terry, J.L., Colbert, J.D., and Riches, D.W. 2003. TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB. Mol. Cell. Biol. 23:8334-8344.
51. de Hoog, C.L., Foster, L.J., and Mann, M. 2004. RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. Cell. 117:649-662.