Carnitine palmitoyltransferase I in liver of periparturient dairy cows: Effects of prepartum intake, postpartum induction of ketosis, and periparturient disorders

Journal of Dairy Science

Volumn 88, Issue 11, 2005, Pages 3851-3859

  Dann, H M ^a,b   Drackley, J K ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b William H Miner Agricultural Research Institute   (United States)

Author keywords

Carnitine palmitoyltransferase I; Ketosis; Lipid metabolism; Liver

Indexed keywords

BOS TAURUS; BOVINAE;

EID: 27644572044     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(05)73070-8     Document Type: Article

References (34)

1. Aiello, R. J., T. M. Kenna, and J. H. Herbein. 1984. Hepatic gluconeogenesis and ketogenic interrelationships in the lactating cow. J. Dairy Sci. 67:1707-1715.
2. Andersen, J. B., D. G. Mashek, T. Larsen, M. O. Nielsen, and K. L. Ingvartsen. 2002. Effects of hyperinsulinaemia under euglycaemic condition on liver fat metabolism in dairy cows in early and mid-lactation. J. Vet. Med. A 49:65-71.
3. Bahaa, A. O., M. R. Murphy, D. E. Morin, S. L. Spahr, J. K. Drackley, T. K. El-Neweehy, and A. A. Abd El-Samee. 1997. Induction of ketosis by feed restriction and treatment of ketosis with glucose or propylene glycol. J. Dairy Sci. 80(Suppl. 1):166. (Abstr.)
4. Brindle, N. P. J., V. A. Zammit, and C. I. Pogson. 1985. Regulation of carnitine palmitoyltransferase activity by malonyl-CoA in mitochondria from sheep liver, a tissue with a low capacity for fatty acid synthesis. Biochem. J. 232:177-182.
5. Bremer, J. 1981. The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA. Biochim. Biophys. Acta 665:628-631.
6. Butler, S. M., A. Faulkner, V. A. Zammit, and R. G. Vernon. 1988. Fatty acid metabolism of the perfused caudate lobe from livers of fed and fasted non-pregnant and fasted late pregnant ewes. Comp. Biochem. Physiol. 91B:25-31.
7. Chow, J. C., and B. W. Jesse. 1992. Interactions between gluconeogenesis and fatty acid oxidation in isolated sheep hepatocytes. J. Dairy Sci. 75:2142-2148.
8. Dann, H. M., G. N. Douglas, T. R. Overton, and J. K. Drackley. 2000. Carnitine palmitoyltransferase activity in liver of periparturient dairy cows. J. Dairy Sci. 83(Suppl. 1):1056. (Abstr.)
9. Dann, H. M., D. E. Morin, G. A. Bollero, M. R. Murphy, and J. K. Drackley. 2005. Prepartum intake, postpartum induction of ketosis, and periparturient disorders affect the metabolic status of dairy cows. J. Dairy Sci. 88:3249-3264.
10. Drackley, J. K. 1999. Biology of dairy cows during the transition period: The final frontier? J. Dairy Sci. 82:2259-2273.
11. Drackley, J. K., T. R. Overton, and G. N. Douglas. 2001. Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. J. Dairy Sci. 84(E. Suppl.):E100-E112.
12. Drynan, L., P. A. Quant, and V. A. Zammit. 1996. The role of changes in the sensitivity of hepatic mitochondrial overt carnitine palmitoyltransferase in determining the onset of the ketosis of starvation in the rat. Biochem. J. 318:767-770.
13. Duffield, T. 2000. Subclinical ketosis in lactating dairy cattle. Vet. Clin. North Am. Food Anim. Pract. 16:231-253.
14. Eaton, S., K. Bartlett, and M. Pourfarzam. 1996. Mammalian mitochondrial β-oxidation. Biochem. J. 320:345-357.
15. Goff, J. P., and R. L. Horst. 1997. Physiological changes at parturition and their relationship to metabolic disorders. J. Dairy Sci. 80:1260-1268.
16. Grantham, B. D., and V. A. Zammit. 1988. Role of carnitine palmitoyltransferase I in the regulation of hepatic ketogenesis during the onset and reversal of chronic diabetes. Biochem. J. 249:409-414.
17. Greenawalt, J. W. 1974. The isolation of outer and inner mitochondrial membranes. Methods Enzymol. 31:310-323.
18. Guzmán, M., G. Velasco, and M. J. H. Geelen. 2000. Do cytoskeletal components control fatty acid translocation into liver mitochondria? Trends Endocrinol. Metab. 11:49-53.
19. Hatcher, L., and E. J. Stepanski. 1994. A Step-by-Step Approach to Using the SAS® System for Univariate and Multivarate Statistics. SAS Institute Inc., Cary, NC.
20. Hughes, J. P. 1962. A simplified instrument for obtaining liver biopsies in cattle. Am. J. Vet. Res. 23:1111-1112.
21. Jesse, B. W., R. S. Emery, and J. W. Thomas. 1986. Control of bovine hepatic fatty acid oxidation. J. Dairy Sci. 69:2290-2297.
22. Kerner, J., and C. Hoppel. 2000. Fatty acid import into mitochondria. Biochim. Biophys. Acta 1486:1-17.
23. Knapp, J. R. 1990. Lactation ketosis: Evaluation of current concepts. Ph.D. Diss., University of California, Davis.
24. Littell, R. C., G. A. Milliken, W. W. Stroup, and R. D. Wolfinger. 1996. SAS System for Mixed Models. SAS Institute Inc., Cary, NC.
25. Louet, J. F., C. Le May, J. P. Pegorier, J. F. Decaux, and J. Girard. 2001. Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids. Biochem. Soc. Trans. 29:310-315.
26. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193:265-275.
27. McGarry, J. D., and N. F. Brown. 1997. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244:1-14.
28. Mersmann, H. J., J. Goodman, J. M. Houk, and S. Anderson. 1972. Studies on the biochemistry of mitochondria and cell morphology in the neonatal swine hepatocyte. J. Cell Biol. 53:335-347.
29. Mizutani, H., T. Sako, N. Takemura, J. Koyama, M. Yamaguchi, and S. Motoyoshi. 1997. Hepatic carnitine palmitoyltransferase activity in cattle. J. Vet. Med. Sci. 59:1067-1069.
30. Mizutani, H., T. Sako, Y. Toyoda, T. Kawabata, N. Urumuhang, H. Koyama, and S. Motoyoshi. 1999. Preliminary studies on hepatic carnitine palmitoyltransferase in dairy cattle with or without fatty liver. Vet. Res. Commun. 23:475-480.
31. National Research Council. 1989. Nutrient Requirements of Dairy Cattle. 6th rev. ed. National Academy Press, Washington, DC.
32. Park, E. A., R. L. Mynatt, G. A. Cook, and K. Kashfi. 1995. Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I. Biochem. J. 310:853-858.
33. Zammit, V. A. 1990. Ketogenesis in the liver of ruminants - adaptations to a challenge. J. Agric. Sci. (Camb.) 115:155-162.
34. Zammit, V. A. 1996. Role of insulin in hepatic fatty acid partitioning: Emerging concepts. Biochem. J. 314:1-14.