No support for association between the dopamine transporter (DAT1) gene and ADHD

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 139 B, Issue 1, 2005, Pages 7-10

  Langley, K ^a   Turic, D ^a   Peirce, T R ^a   Mills, S ^a   Van Den Bree, M B ^a   Owen, M J ^a   O'Donovan, M C ^a   Thapar, A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Attention deficit hyperactivity disorder (ADHD); Dopamine transporter (DAT1); Haplotype; Medication response; Promoter polymorphism

Indexed keywords

3' UNTRANSLATED REGION; ADOLESCENT; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; DAT1 GENE; DNA POLYMORPHISM; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HUMANS; MALE; METHYLPHENIDATE; MINISATELLITE REPEATS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 27644570110     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30206     Document Type: Article

References (21)

1. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. 1997. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Results 25(17):3389-3402.
2. Barr C, Xu C, Kroft J, Feng Y, Wigg K, Zai G, Tannock R, Schachar R, Malone M, Roberts W, Nöthen F, Grnhage F, Vandenburgh DJ, Uhl G, Sunhotra G, King N, Kennedy JL. 2001. Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention deficit/hyperactivity disorder. Biol Psychiatry 49:333-339.
3. Clayton D. 1999. A generalization of the transmission/disequilibrium test for uncertain haplotype transmission. Am J Hum Genet 65:1170-1177.
4. Coleman SL, Buckland PR, Hoogendoorn B, Guy C, Smith K, O'Donovan MC. 2002. Experimental analysis of the annotation of promoters in the public database. Hum Mol Genet 11(16):1817-1821.
5. Daly G, Hawi Z, Fitzgerald M, Gill M. 1999. Mapping susceptibility loci in attention deficit hyperactivity disorder: Potential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Molecular Psychiatry 4:192-196.
6. Greenwood TA, Kelsoe JR. 2003. Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene. Genomics 82(5):511-520.
7. Guy W. 1976. ECDELL assessment manual for psychoparmacology. Washington DC: Department of Health, Education & Welfare, pp 217-222.
8. Hamarman S, Ulger J, Fossella J, Brinacombe M, Dermondy J. 2003. Influence of dopamine genes on stimulant response in children. Scientific Proceedings of the 156th Annual Meeting of the American Psychiatric Association.
9. Holmes J, Payton A, Barrett JH, Hever T, Fitzpatrick H, Trumper AL, Harrington R, McGuffin P, Owen M, Ollier W, Worthington J, Thapar A. 2000. A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder. Mol Psychiatry 5:523-530.
10. Hsu TM, Chen X, Duan S, Miller RD, Kwok PY. 2001. Universal SNP genotyping assay with fluorescence polarization detection. Biotechniques 31:560-568.
11. Jones AC, Austin J, Hansen N, Hoogendoorn B, Oefner PJ, Cheadle JP, O'Donovan MC. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 8(1):1133-1140.
12. Kirley A, Lowe N, Hawi Z, Mullins C, Daly G, Waldman I, McCarron M, O'Donnell D, Fitzgerald M, Gill M. 2003. Association of the 480bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD. Am J Med Genet (Neuropsychiatr Genet) 121b:50-54.
13. Maher BS, Marazita ML, Ferrell RE, Vanyukov MM. 2002. Dopamine system genes and attention deficit hyperactivity disorder: A meta-analysis. Psychiatr Genet 12(4):207-215.
14. Norton N, Williams NM, Williams HJ, Spurlock G, Kirov G, Morris DW, Hoogendoorn B, Owen MJ, O'Donovan MC. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5):471-478.
15. Roman T, Szobot C, Martins S, Biederman J, Rohde LA, Hutz MH. 2002. Dopamine transporter gene and response to methylphenidate in attention deficit/hyperactivity disorder. Pharmacogenetics 12(6):497-499.
16. Rubie C, Schmidt F, Knapp M, Sprandel J, Wiegand C, Meyer J, Jungkunz G, Riederer P, Stober G. 2001. The human dopamine transporter gene: The 5′-flanking region reveals five diallelic polymorphic sites in a Caucasian population sample. Neurosci Lett 297(2):125-128.
17. Stein MA, Waldman I, Sarampote C, Seymour K, Robb A, Conlon C, Yang Z, Cook EH. 2002. Dopamine transporter genotype (DAT1) affects stimulant response in children with ADHD. Conference Proceedings American Society of Human Genetics 2002.
18. Todd RD, Jong YJ, Lobos EA, Reich W, Heath AC, Neumann RJ. 2001. No association of the dopamine transporter 3′ UTR VNTR polymorphism with ADHD subtypes in a population of twins. Am J Med Genet 105(8):745-758.
19. Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland HH, Sanders ML, Gard JMC, Stever C. 1998. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: Heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63:1767-1776.
20. Winsberg BG, Comings DE. 1999. Association of the dopamine transporter gene (DAT1) with poor methylphenidate response. J Am Acad Child Adolesc Psychiatry 38(12):1474-1477.
21. Xu X, Horvath S, Laird N. 2000. The FBAT (family based association test) Program: Testing for linkage and association with family data. [1.2]. http://biosun1.harvard.edu/~fbat/fbatdoc.html, Harvard School of Public Health, Harvard University, Massachusetts, USA.