Gas-phase chemistry of the negative ions of fully-protected peptides by high-resolution electrospray ionization tandem mass spectrometry

European Journal of Mass Spectrometry

Volumn 11, Issue 4, 2005, Pages 403-408

  Napoli, Anna ^a   Di Donna, Leonardo ^a   Sindona, Giovanni ^a   Urso, Elena ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Calcitonin synthetic peptides negative ions; ESI QqTof of protected peptides negative ions; High resolution CID ( ) of protected peptides; Protected peptide negative ions

Indexed keywords

CALCITONIN; PEPTIDE FRAGMENT;

ANIMAL; ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GAS; METHODOLOGY; PEPTIDE MAPPING; SWINE; SYNTHESIS;

ANIMALS; CALCITONIN; GASES; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SWINE;

EID: 27644556902     PISSN: 14690667     EISSN: None     Source Type: Journal    
DOI: 10.1255/ejms.769     Document Type: Article

References (29)

1. K. Bieman, "Contributions of mass spectrometry to peptide and protein structure", Biomed. Environ. Mass Spectrom. 16, 99 (1988).
2. K. Bieman and S.A. Martin, "High-temperature Mass-spectrometry and Studies of Ion-Ion, Ion-Molecule, and Molecule-Molecule Equilibria", Mass Spectrom. Rev. 6, 1 (1978).
3. K.L. Busch, L. Glish and S.A. McLuckey in Mass spectrometry/Mass spectrometry: Techniques and Applications of Tandem Mass Spectrometry. VCH, New York, USA (1988).
4. K. Eckart, H. Schwarz, G. Becker and H. Kessler, "Monitoring and optimization of deprotection reactions of peptides by direct sampling with fast atom bombardment mass spectrometry", J. Org. Chem. 51, 483 (1986).
5. P. Athanassopoulos, K. Barlos, D. Gatos, O. Hatzi and C. Tzavara, "Application of 2-chlorotrityl chloride in convergent peptide- synthesis", Tetrahedron Lett. 36, 5645 (1995).
6. K. Barlos, D. Gatos and W. Shäfer "Synthesis of prothymosin alpha (pro t-alpha) - A protein consisting of 109 amino-acid-residues", Angew. Chem. Int. Ed. Engl. 30, 590 (1991).
7. J.T. Watson, D.S. Wagner, Y.S. Chang, J.R. Strahler, S.M. Hanash and D.A. Gage "Characterization of the ethyl-triphenyl-phosphonium derivative of model peptides by fast atom bombardment collisionally-activated dissociation tandem mass spectrometry using B/E linked scans", Int. J. Mass Spectrom. Ion Processes 111, 191 (1991).
8. J. Schaller, B.C. Pellascio and U.P. Schlunegger, "Analysis of hydrophobic proteins and peptides by electrospray ionization mass spectrometry", Rapid Commun. Mass Spectrom. 11, 418 (1997).
9. K.D.W. Roth, Z.H. Huang, N. Sadagopan and J.T. Watson, "Charge derivatization of peptides for analysis by mass spectrometry", Mass Spectrom. Rev. 17, 255 (1998).
10. K. Barlos, D. Gatos, J. Kallitsis, G. Papaphotiu, P. Sotiriu, Y. Wenging and W. Schäfer, "Darstellung geschützter peptidfragmente unter einsatz substituierter triphenylmethyl-harge", Tetrahedron Lett. 30, 3943 (1989).
11. P. Ferranti, G. Mamone and A. Malorni, "Preparation and mass spectrometric analysis of S-nitrosohemoglobin", Methods Mol. Biol. 146, 147 (2000)
12. J. Banoub, A. Cohen, A. Mansour and P. Thibault, "Characterization and de novo sequencing of Atlantic salmon vitellogenin protein by electrospray tandem and matrix-assisted laser desorption/ionization mass spectrometry", Eur. J. Mass Spectrom. 10, 121 (2004).
13. (a) S.K. Chowdhury, V. Katta and B.T. Chait, "Probing conformational-changes in proteins by mass-spectrometry", J. Am. Chem. Soc. 112, 9012 (1990);
14. (b) B.E. Winger, K.J. Lightwahl, R. Loo, H.R. Udseth and R.D. Smith, "Observation and implications of high mass-to-charge ratio ions from electrospray-ionization mass-spectrometry", J. Am. Soc. Mass Spectrom. 4, 536 (1993).
15. C. Cheng and M.L. Gross, "Applications and mechanisms of charge-remote fragmentation", Mass Spectrom. Rev. 19, 398 (2000).
16. J.H. Bowie, Mass Spectrom. Spec. Period Rep. 8, 161 (1985)
17. J.H. Bowie, Mass Spectrom. Spec. Period Rep. and 9, 172 (1987).
18. A.R. Dongre, J.L. Jones, A. Somoygi and V.H. Wysocki, "Influence of peptide composition, gas-phase basicity, and chemical modification on fragmentation efficiency: Evidence for the mobile proton model", J. Am. Chem. Soc. 118, 8365 (1996).
19. R.S. Johnson, D. Krylov and K.A. Walsh, "Proton mobility within electrosprayed peptide ions", J. Mass Spectrom. 30, 386 (1995).
20. X.J. Tang, P. Thibault and R.K. Boyd, "Fragmentation reactions of multiply-protonated peptides and implications for sequencing by tandem mass-spectrometry with low-energy collision-induced dissociation", Anal. Chem. 65, 2824 (1993).
21. M. Eckersley, J.H. Bowie and R.N. Hayes, "Collision-induced dissociations of deprotonated -amino acids. The occurrence of specific proton transfers preceding fragmentation", Int. J. Mass Spectrom. Ion Processes 93, 199 (1989).
22. M. Eckersley, J.H. Bowie and R.N. Hayes, "Collision-induced dissociations of deprotonated peptides, dipeptides and tripeptides with hydrogen and alkyl groups. An aid to structure determination", Org. Mass Spectrom. 24, 597 (1989).
23. R.J. Waugh, M. Eckersley, J.H. Bowie and R.N. Hayes, "Collision- induced dissociations of deprotonated peptides - dipeptides containing serine or threonine", Int. J. Mass Spectrom. Ion Processes 98, 135 (1990).
24. J. Russell, R.J. Waugh, J.H. Bowie and R.N. Hayes, "Collision- induced dissociations of deprotonated peptides. Dipeptides containing aspartic or glutamic acids", Org. Mass Spectrom. 26, 250 (1991).
25. 24 Asterisks denote the presence of a masking group.
26. P. Roepstorff and J. Fohlman, "Proposal for a common nomenclature for sequence ions in mass mass spectra of peptides", Biomed. Mass Spectrom. 11, 601 (1984).
27. (a) S.A. McLuckey, G.J. Vanberkel and G.L. Glish, "Reactions of dimethylamine with multiply charged ions of cytochrome-c", J. Am. Chem. Soc. 112, 5668 (1990);
28. (b) B.E. Winger, K.J. Lightwahl and R.D. Smith, "Gas-phase proton-transfer reactions involving multiply charged cytochrome-c ions and water under thermal conditions", J. Am. Soc. Mass Spectrom. 3, 624 (1992).
29. L. Di Donna, A. Liguori, A. Napoli and G. Sindona, "Energetics of an intracluster -elimination process driven by acetate anions. The case of a Fmoc-protected peptide investigated by high-resolution electrospray ionization tandem mass spectrometry", J. Mass Spectrom. 38, 778 (2003).