Androgenic correlates of genetic variation in the gene encoding 5α-reductase type 1

Journal of Human Genetics

Volumn 50, Issue 10, 2005, Pages 534-537

  Ellis, Justine A ^a   Panagiotopoulos, Sianna ^b   Akdeniz, Aysel ^b   Jerums, George ^b   Harrap, Stephen B ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HEALTH   (Australia)

Author keywords

Androgen; Dihydrotestosterone; Genetic association; Insulin; Single nucleotide polymorphism; Testosterone

Indexed keywords

ANDROGEN; ANDROSTANOLONE; OXIDOREDUCTASE; TESTOSTERONE;

ADULT; AGED; ARTICLE; ENZYME ACTIVITY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ANDROGENS; CHOLESTENONE 5 ALPHA-REDUCTASE; DIABETES MELLITUS, TYPE 2; DIHYDROTESTOSTERONE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 27644543473     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-005-0289-x     Document Type: Article

References (14)

1. Ellis JA, Stebbing M, Harrap SB (1998) Genetic analysis of male pattern baldness and the 5α-reductase genes. J Invest Dermatol 110:849-853
2. Janne OA, Palvimo JJ, Kallio P, Mehto M (1993) Androgen receptor and mechanism of androgen action. Ann Med 25:83-89
3. Jenkins EP, Hseih CH, Milatovich A, Normington K, Berman DM, Francke U, Russell DW (1991) Characterisation and chromosomal mapping of a human steroid 5α-reductase gene and pseudogene and mapping of the mouse homologue. Genomics 11:1102-1112
4. Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW (1992) Genetic and pharmacological evidence for more than one human steroid 5α-reductase. J Clin Invest 89:293-300
5. Livingstone C, Collison M (2002) Sex steroids and insulin resistance. Clin Sci 102:151-166
6. MacIsaac R, Tsalamandris C, Panagiotopoulos S, Smith TJ, McNeil KJ, Jerums G (2004) Nonalbuminuric renal insufficiency in type 2 diabetes. Diabetes Care 27:195-200
7. Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, Riley J, Finch KL, Stevens JF, Livak KJ, Slotterbeck BD, Slifer SH, Warren LL, Conneally PM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, Vance JM (2000) SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum Genet 67:383-394
8. Meikle AW, Bishop DT, Stringham JD, West DW (1986) Quantitating genetic and non-genetic factors that determine plasma sex steroid variation in normal male twins. Metabolism 35:1090-1095
9. Meikle AW, Stringham JD, Bishop T, West DW (1988) Quantitating genetic and non-genetic factors influencing androgen production and clearance rates in men. J Clin Endocrinol Metab 67:104-109
10. Randall VA (1997) The role of androgens in the regulation of the human hair follicle. In: Azziz R, Nestler JE, Dewailly D (eds) Androgen excess disorders in women. Lippincott-Raven, Philadelphia, pp 115-129
11. Thigpen AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell DW (1993) Tissue distribution and ontogeny of steroid 5α-reductase isozyme expression. J Clin Invest 92:903-910
12. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C (2004) Androgens and bone. Endocr Rev 25:389-425
13. Vermeulen A, Verdonck L, Kaufman JM (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672
14. Wu FCW, von Eckardstein A (2003) Androgens and coronary artery disease. Endocr Rev 24:183-217