Histopathological and ultrastructural effects of Losartan on embryonic rat kidney

Acta Histochemica

Volumn 107, Issue 4, 2005, Pages 291-300

  Akil, Ipek ^a   Inan, Sevinc ^a   Gurcu, Beyhan ^a   Nazikoglu, Aysegul ^b   Ozbilgin, Kemal ^a   Muftuoglu, Sevda ^b  

^a CELAL BAYAR UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Electron microscopy; Losartan; Renal development; TGF

Indexed keywords

BIOLOGICAL ORGANS; CELLS; ELECTRON MICROSCOPY; ENZYMES; MICROSCOPIC EXAMINATION; PATHOLOGY; VITAMINS;

HISTOPATHOLOGY; LOSARTAN; RENAL DEVELOPMENT; TGF-Β;

HISTOLOGY;

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; AVIDIN; BIOTIN; FORMALDEHYDE; GLUTARALDEHYDE; LOSARTAN; OSMIUM TETRAOXIDE; PARAFFIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONAL TISSUE; EPITHELIUM CELL; GLOMERULUS BASEMENT MEMBRANE; HISTOPATHOLOGY; IMMUNOREACTIVITY; KIDNEY; KIDNEY DEVELOPMENT; KIDNEY EPITHELIUM; KIDNEY PARENCHYMA; LEYDIG CELL; MEASUREMENT; NEPHRON; NEPHROTOXICITY; NONHUMAN; RAT; THICKNESS; TOXICOKINETICS;

ANIMALIA;

EID: 27644537521     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2005.06.011     Document Type: Article

References (24)

1. M. Aunapuu, Ü. Pechter, A. Arend, T. Suuroja, and M. Ots Ultrastructural changes in the remnant kidney (after 5/6 nephrectomy) glomerulus after Losartan and atenolol treatment Medicina 39 2003 975 979
2. D.P. Basile, D.R. Martin, and M.R. Hammerman Extracellular matrix-related genes in kidney after ischemic injury: potential role for TGF-β in repair Am J Physiol 275 1998 F894 F903
3. J.W. Brock, T.E. Hunley, M.C. Adams, and V. Kon Role of the renin-angiotensin system in disorders of the urinary tract J Urol 160 1998 1812 1819
4. E.A. Burdmann, T.F. Andoh, C.C. Nast, A. Evan, B.A. Connors, and T.M. Coffman Prevention of experimental cyclosporin-induced insterstitial fibrosis by Losartan and enalapril Am J Physiol 269 1995 F491 F499
5. C.R. Burrow Regulatory molecules in kidney development Pediatr Nephrol 14 2000 240 253
6. W. Bursch, F. Oberhammer, L. Jirtle, M. Askari, R. Sedivy, B. Grasl-Kraupp, A.F. Purchio, and R. Schulte-Hermann Transforming growth factor-β1 as signal for induction of cell death by apoptosis Br J Cancer 67 1993 531 536
7. R.L. Chevalier, K.H. Chung, C.D. Smith, M. Ficenec, and R.A. Gomez Renal apoptosis and clusterin following uretheral obstruction: the role of maturation J Urol 156 1996 1474 1479
8. A.T. Clark, R.J. Young, and J.F. Bertram In vitro studies on the roles of transforming growth factor-beta 1 in rat metanephric development Kidney Int 59 2001 1641 1653
9. Y. Frishberg, and C.J. Kelly TGF-β and regulation of interstitial nephritis Miner Electrolyte Metab 24 1998 181 189
10. R.A. Gomez, S. El-Dahr, and R.L. Chevalier Vasoactive hormones T.M. Barratt E.D. Avner W.E. Harmon Pediatric nephrology 1999 Lippincott, Williams & Wilkins Baltimore 83 99
11. J. Heino, R.A. Ignotz, M.E. Hemler, C. Crouse, and J. Massague Regulation of cell adhesion receptors by transforming growth factor-β J Biol Chem 264 1989 380 388
12. J.E. McCausland, J.F. Bertram, G.B. Ryan, and D. Alcorn Glomerular number and size following chronic angiotensin II blockade in the postnatal rat Exp Nephrol 5 1997 201 209
13. F. Niimura, S. Okuba, A. Fogo, and I. Ichikawa Temporal and spatial expression pattern of the angiotensinogen gene in mice and rats Am J Physiol 41 1997 R147
14. M. Pohl, R.O. Stuart, H. Sakurai, and S.K. Nigam Branching morphogenesis during kidney development Annu Rev Physiol 62 2000 595 620
15. A.B. Roberts, B.K. McCune, and M.B. Sporn TGF-β: regulation of extracellular matrix Kidney Int 41 1992 557 559
16. L. Saward, and P. Zahradka The angiotensin type 2 receptor mediates RNA synthesis in A10 vascular smooth muscle cells J Mol Cell Cardiol 28 1996 499 506
17. S. Schultz, J.M. Le Moullec, P. Corvol, and J.M. Gasc Early expression of all the components of the renin-angiotensin system in human development Am J Pathol 149 1996 2067 2079
18. S.G. Spence, H.L. Allen, M.A. Cukierski, J.M. Manson, R.T. Robertson, and R.S. Eydelloth Defining the susceptible period of developmental toxicity for the AT1-selective angiotensin II receptor antagonist Losartan in rats Teratology 51 1995 367 382
19. T. Tsukada, K. Eguchi, K. Migita, Y. Kawabe, A. Kawakami, and N. Matsuoka Transforming growth factor-β1 induces apoptotic cell death in cultured human umbilical vein endothelial cells with down-regulated expression of bcl-2 Biochem Biophys Res Commun 210 1995 1076 1082
20. A. Tufro-McReddie, L.M. Romano, J.M. Harris, L. Ferder, and R.A. Gomez Angiotensin II regulates nephrogenesis and renal vascular development Am J Physiol 269 1995 F110 F115
21. E.J.J. Van Zoelen, and L.G.J. Tertoolen Transforming growth factor-β enhances the extent of intercellular communication between normal rat kidney cells J Biol Chem 266 1991 12075 12081
22. A.S. Wolf Embryology of the kidney T.M. Barratt E.D. Avner W.E. Harmon Pediatric nephrology 1999 Lippincott, Williams & Wilkins Baltimore 1 19
23. G. Wolf Angiotensin II and tubular development Nephrol Dial Transplant 17 2002 48 51
24. G. Wolf, and E.G. Neilson Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells Am J Physiol 259 1990 F768 F777