Identification and characterization of an immunogenic 22 kDa exported protein of Mycobacterium avium subspecies paratuberculosis

Journal of Medical Microbiology

Volumn 54, Issue 11, 2005, Pages 1083-1092

  Dupont, Chris ^a,c   Thompson, Keith ^a   Heuer, Cord ^a   Gicquel, Brigitte ^b   Murray, Alan ^a  

^a MASSEY UNIVERSITY   (New Zealand)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ANTIBODY; BACTERIAL PROTEIN; GAMMA INTERFERON; LIPOPROTEIN; LIVE VACCINE; P22 ANTIGEN; POLYHISTIDINE; PROTEIN LPPX; PROTEIN LPRAFG; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ARTICLE; BACTERIUM CULTURE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE FUSION; GENE LIBRARY; IMMUNOGENICITY; MYCOBACTERIAL EXPRESSION VECTOR; MYCOBACTERIUM AVIUM; MYCOBACTERIUM INTRACELLULARE; MYCOBACTERIUM SCROFULACEUM; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PARATUBERCULOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SHEEP; SUPERNATANT; ULTRASOUND; VACCINATION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BLOTTING, WESTERN; CATTLE; CLONING, MOLECULAR; DNA, BACTERIAL; INTERFERON TYPE II; LIPOPROTEINS; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MYCOBACTERIUM AVIUM; MYCOBACTERIUM AVIUM COMPLEX; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM PARATUBERCULOSIS; MYCOBACTERIUM SCROFULACEUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; OPEN READING FRAMES; PROTEIN SORTING SIGNALS; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID; SHEEP;

EID: 27644531470     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.46163-0     Document Type: Article

References (48)

1. Andersen, P. (1997). Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis. Scand J Immunol 45, 115-131.
2. Andersen, P., Askgaard, D., Ljungqvist, L, Bennedsen, J. & Heron, I. (1991). Proteins released from Mycobacterium tuberculosis during growth. Infect Immun 59, 1905-1910.
3. Armoa, G. R. G., Rouse, D. A., Nair, J., Mackall, J. C. & Morris, S. L. (1995). A highly immunogenic putative Mycobacterium kansasii lipoprotein. Microbiology 141, 2705-2712.
4. Bigi, F., Espitia, C., Alito, A., Zumarraga, M., Romano, M. I., Cravero, S. & Cataldi, A. (1997). A novel 27 kDa lipoprotein from Mycobacterium bovis. Microbiology 143, 3599-3605.
5. Bigi, F., Gioffre, A., Klepp, L. & 9 other authors (2004). The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis. Microbes Infect 6, 182-187.
6. Boddinghaus, B., Rogall, T., Flohr, T., Blocker, H. & Bottger, E. C. (1990). Detection and identification of mycobacteria by amplification of rRNA. J Clin Microbiol 28, 1751-1759.
7. Braun, V. & Wu, H. C. (1984). Lipoproteins, structure, function, biosynthesis and model for protein export. In New Comprehensive Biochemistry, vol 27. pp. 319-341. Edited by J.-M. Ghuysen & R. Hakenbeck. Amsterdam: Elsevier.
8. Buergelt, C. D., Hall, C. E., Merkal, R. S., Whitlock, R. H. & Duncan, J. R. (1977). Lymphocyte transformation: an aid in the diagnosis of paratuberculosis. Am J Vet Res 38, 1709-1715.
9. Cameron, R. M., Stevenson, K., Inglis, N. F., Klausen, J. & Sharp, J. M. (1994). Identification and characterization of a putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis. Microbiology 140, 1977-1982.
10. Collett, M. & West, D. M. (2001). A comparison of the injection site and draining lymph node pathology induced by an attenuated live and a killed Johne's disease vaccine in sheep. In Proceedings of the 5th International Sheep Veterinary Congress, pp. 28-29. South Africa: Stellenbosch.
11. Collins, D. M., Gabric, D. M. & de Lisle, G. W. (1990). Identification of two groups of Mycobacterium paratuberculosis strains by restriction endonuclease analysis and DNA hybridization. J Clin Microbiol 28, 1591-1596.
12. Cousins, D. V., Bastida, R., Cataldi, A. & 15 other authors (2003). Tuberculosis in seals caused by a novel member of the Mycobacterium tuberculosis complex: Mycobacterium pinnipedii sp. nov. Int J Syst Evol Microbiol 53, 1305-1314.
13. De Kesel, M., Gilot, P., Misonne, M. C., Coene, M. & Cocito, C. (1993). Cloning and expression of portions of the 34-kilodalton-protein gene of Mycobacterium paratuberculosis: its application to serological analysis of Johne's disease. J Clin Microbiol 31, 947-954.
14. de Lisle, G. W. & Duncan, J. R. (1981). Bovine paratuberculosis III. An evaluation of a whole blood lymphocyte transformation test. Can J Comp Med 45, 304-309.
15. Dohoo, I. R., Martin, W. S. & Stryhn, H. (2003). Veterinary Epidemiologic Research. Charlottetown, Canada: AVC.
16. Dupont, C. & Murray, A. (2001). Identification, cloning and expression of sodC from an alkaline phosphatase gene fusion library of Mycobacterium avium subspecies paratuberculosis. Microbios 106 (Suppl. 1), 7-19.
17. El-Zaatari, F. A., Naser, S. A. & Graham, D. Y. (1997). Characterization of a specific Mycobacterium paratuberculosis recombinant clone expressing 35,000-molecular-weight antigen and reactivity with sera from animals with clinical and subclinical Johne's disease. J Clin Microbiol 35, 1794-1799.
18. Florio, W., Freer, G., Daila Casa, B., Batoni, G., Maisetta, G., Senesi, S. & Campa, M. (1997). Comparative analysis of subcellular distribution of protein antigens in Mycobacterium bovis bacillus Calmette-Guerin. Can J Microbiol 43, 744-750.
19. Gay, G., Burbidge, H. M., Bennet, P., Fenwick, S. G., Dupont, C., Murray, A. & Alley, M. R. (2000). Pulmonary Mycobacterium bovis infection in a dog. N Z Vet J 48, 78-81.
20. Gehring, A. J., Dobos, K. M., Belisle, J. T., Harding, C. V. & Boom, W. H. (2004). Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing. J Immunol 173, 2660-2668.
21. Harris, N. B. & Barletta, R. G. (2001). Mycobacterium avium ssp. paratuberculosis in veterinary medicine. Clin Microbiol Rev 14, 489-512.
22. Hintz, A. M. (1981). Comparative lymphocyte stimulation studies on whole blood from vaccinated and nonvaccinated cattle with paratuberculosis. Am J Vet Res 42, 507-510.
23. Hope, A. F., Kluver, P. F., Jones, S. L. & Condron, R. J. (2000). Sensitivity and specificity of two serological tests for the detection of ovine paratuberculosis. Aust Vet J 78, 850-856.
24. Hovav, A.-H, Mullerad, J., Davidovitch, L., Fishman, Y., Bigi, F., Cataldi, A. & Bercovier, H. (2003). The Mycobacterium tuberculosis recombinant 27-Kilodalton lipoprotein induces a strong Th1-Type immune response deleterious to protection. Infect Immun 71, 3146-3154.
25. Hunter, E. B., Duignan, P. J., Dupont, C., Fray, L., Fenwick, S. G. & Murray, A. (1998). First report of potentially zoonotic tuberculosis in fur seals in New Zealand. N Z Med J 111, 130-131.
26. Huygen, K., Content, J., Denis, O. & 13 other authors (1996). Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat Med 2, 893-898.
27. Imaeda, T., Broslawski, G. & Imaeda, S. (1988). Genomic relatedness among mycobacterial species by nonisotopic blot hybridization. Int J Syst Bacteriol 38, 151-156.
28. Kohler, H., Gyra, H., Zimmer, K. & 7 other authors (2001). Immune reactions in cattle after immunization with Mycobacterium paratuberculosis vaccine and implications for the diagnosis of M. paratuberculosis and M. bovis infections. J Vet Med B Infect Dis Vet Public Health 48, 185-195.
29. Le Dantec, C., Winter, N., Gicquel, B., Vincent, V. & Picardeau, M. (2001). Genomic sequence and transcriptional analysis of a 23-kilobase mycobacterial linear plasmid: evidence for horizontal transfer and identification of plasmid maintenance systems. J Bacteriol 183, 2157-2164.
30. Lefevre, P., Denis, O., De Wit, L., Tanghe, A., Vandenbussche, P., Content, J. & Huygen, K. (2000). Cloning of the gene encoding a 22-kilodalton cell surface antigen of Mycobacterium bovis BCG and analysis of its potential for DNA vaccination against tuberculosis. Infect Immun 68, 1040-1047.
31. Lim, E. M., Rauzier, J., Timm, J., Torrea, G., Murray, A., Gicquel, B. & Portnoi, D. (1995). Identification of Mycobacterium tuberculosis DNA sequences encoding exported proteins by using phoA gene fusions. J Bacteriol 177, 59-65.
32. Lozes, E., Huygen, K., Content, J. & 8 other authors (1997). Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex. Vaccine 15, 830-833.
33. Olsen, I., Tryland, M., Wiker, H. G. & Reitan, L. J. (2001). AhpC, AphD and a secreted 14-kilodalton antigen from Mycobacterium avium subspecies paratuberculosis distinguish between paratuberculosis and bovine tuberculosis in an enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol 8, 797-801.
34. Orme, I. M., Roberts, A. D., Griffin, J. P. & Abrams, J. S. (1993). Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol 151, 518-525.
35. Sambrook, J., Fritsch, E. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
36. Sankaran, K. & Wu, H. C. (1994). Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol. J Biol Chem 269, 19701-19706.
37. Sankaran, K., Gupta, S. D. & Wu, H. C. (1995). Modification of bacterial lipoproteins. Methods Enzymol 250, 683-697.
38. Snapper, S. B., Melton, R. E., Mustafa, S., Kieser, T. & Jacobs, W. R., Jr (1990). Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol 4, 1911-1919.
39. Sockett, D. C., Conrad, T. A., Thomas, C. B. & Collins, M. T. (1992a). Evaluation of four seological tests for bovine paratuberculosis. J Clin Microbiol 30, 1134-1139.
40. Sockett, D. C., Carr, D. J. & Collins, M. T. (1992b). Evaluation of conventional and radiometric fecal culture and a commercial DNA probe for diagnosis of Mycobacterium paratuberculosis infections in cattle. Can J Vet Res 56, 148-153.
41. Stabel, J. R. (2000). Transitions in immune responses to Mycobacterium paratuberculosis. Vet Microbiol 77, 465-473.
42. Sutcliffe, I. C. & Russell, R. R. (1995). Lipoproteins of Gram-positive bacteria. J Bacteriol 177, 1123-1128.
43. Tanghe, A., Denis, O., Lambrecht, B., Motte, V., van den Berg, T. & Huygen, K. (2000). Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment. Infect Immun 68, 3854-3860.
44. Thorel, M. F., Huchzermeyer, H. F. & Michel, A. L. (2001). Mycobacterium avium and Mycobacterium intracellulare infection in mammals. Rev Sci Tech 20, 204-218.
45. von Heijne, G. (1985). Signal sequences. The limits of variation. J Mol Biol 184, 99-105.
46. von Heijne, G. (1989). The structure of signal peptides from bacterial lipoproteins. Protein Eng 2, 531-534.
47. Wayne, L. G. (1984). Mycobacterial speciation. In The Mycobacteria: a Source Book, Part A, pp. 25-66. Edited by G. P. Kubica & L. G. Wayne. New York. Marcel Dekker.
48. Wiker, H. G., Harboe, M. & Nagai, S. (1991). A localization index for distinction between extracellular and intracellular antigens of Mycobacterium tuberculosis. J Gen Microbiol 137, 875-884.