Mouse brain synaptosomes accumulate copper-67 efficiently by two distinct processes independent of cellular prion protein

Journal of Molecular Neuroscience

Volumn 27, Issue 3, 2005, Pages 347-354

  Giese, Armin ^a   Buchholz, Malte ^a,b   Herms, Jochen ^a   Kretzschmar, Hans A ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER 67; EDETIC ACID; HISTIDINE; NICKEL CHLORIDE; PRION PROTEIN; PROTEIN ANTIBODY; ZINC CHLORIDE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOACCUMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; KNOCKOUT MOUSE; MOUSE; NERVE ENDING; NONHUMAN; PROTEIN BINDING; SYNAPTIC MEMBRANE; SYNAPTOSOME; TRANSPORT KINETICS; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL TRANSPORT; BRAIN; CHELATING AGENTS; COPPER; EDETIC ACID; HISTIDINE; MICE; MICE, KNOCKOUT; PRPC PROTEINS; SYNAPTOSOMES;

ANIMALIA;

EID: 27644529810     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:27:3:347     Document Type: Article

References (32)

1. Barnea A., Hartter D. E., Cho G., Bhasker K. R., Katz B. M., and Edwards M. D. (1990) Further characterization of the process of in vitro uptake of radiolabeled copper by the rat brain. J. Inorg. Biochem. 40, 103-110.
2. Barnham K. J., McKinstry W. J., Multhaup G., Galatis D., Morton C. J., Curtain C. C., et al. (2003) Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J. Biol. Chem. 278, 17,401-17,407.
3. Bertinato J. and L'Abbe M. R. (2004) Maintaining copper homeostasis: regulation of copper-trafficking proteins in response to copper deficiancy or overload. J. Nutr. Biochem. 15, 316-322.
4. Brown L. R. and Harris D. A. (2003) Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi. J. Neurochem. 87, 353-363.
5. Brown D. R., Qin K., Herms J. W., Madlung A., Manson J., Strome R., et al. (1997) The cellular prion protein binds copper in vivo. Nature 390, 684-687.
6. Büeler H., Fischer M., Lang Y., Bluethmann H., Lipp H. P., DeArmond S. J., et al. (1992) Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356, 577-582.
7. Bush A. I. (2000) Metals and neuroscience. Curr. Opin. Chem. Biol. 4, 184-191.
8. Collinge J., Whittington M. A., Sidle K. C., Smith C. J., Palmer M. S., Clarke A. R., and Jefferys J. G. (1994) Prion protein is necessary for normal synaptic function. Nature 370, 295-297.
9. Deutsch C., Drown C., Rafalowska U., and Silver I. A. (1981) Synaptosomes from rat brain: morphology, compartmentation, and transmembrane pH and electrical gradients. J. Neurochem. 36, 2063-2072.
10. Hajos F. (1975) An improved method for the preparation of synaptosomal fractions in high purity. Brain Res. 93, 485-489.
11. Harris E. D., Qian Y., and Reddy M. C. M. (1998) Genes regulating copper metabolism. Mol. Cell. Biochem. 188, 57-62.
12. Hartter D. E. and Barnea A. (1988) Brain tissue accumulates 67copper by two ligand-dependent saturable processes. A high affinity, low capacity and a low affinity, high capacity process. J. Biol. Chem. 263, 799-805.
13. Herms J., Tings T., Gall S., Madlung A., Giese A., Siebert H., et al. (1999) Evidence of presynaptic location and function of the prion protein. J. Neurosci. 19, 8866-8875.
14. Horning M. S. and Trombley P. Q. (2001) Zinc and copper influence excitability of rat olfactory bulb neurons by multiple mechanisms. J. Neurophysiol. 86, 1652-1660.
15. Hornshaw M. P., McDermott J. R., and Candy J. M. (1995a) Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein. Biochem. Biophys. Res. Commun. 207, 621-629.
16. Hornshaw M. P., McDermott J. R., Candy J. M., and Lakey J. H. (1995b) Copper binding to the N-terminal tandem repeat region of mammalian and avian prion protein: structural studies using synthetic peptides. Biochem. Biophys. Res. Commun. 214, 993-999.
17. Jackson G. S., Murray I, Hosszu L. L., Gibbs N., Waltho J. P., Clarke A. R., and Collinge J. (2001) Location and properties of metal-binding sites on the human prion protein. Proc. Natl. Acad. Sci. U. S. A. 98, 8531-8535.
18. Krasemann S., Groschup M. H., Harmeyer S., Hunsmann G., and Bodemer W. (1996) Generation of monoclonal antibodies against human prion proteins in PrP0/0 mice. Mol. Med. 2, 725-734.
19. Leiva J., Palestini M., Tetas M., and Lopez J. (2000) Copper sensitivity in dorsal hippocampus slices. Arch. Ital. Biol. 138, 175-184.
20. Linder M. C. (1991) Biochemistry of Copper, Plenum Press, New York.
21. Mallucci G. R., Ratte S., Asante E. A., Linehan J., Gowland I., Jefferys J. G., and Collinge J. (2002) Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. EMBO J. 21, 202-210.
22. McMahon H. T., Foran P., Dolly J. O., Verhage M., Wiegant V. M., and Nicholls D. G. (1992) Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action. J. Biol. Chem. 267, 21,338-21,343.
23. Multhaup G., Scheuermann S., Schlicksupp A., Simons A., Strauss M., Kemmling A., et al. (2002) Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease. Free Radic. Biol. Med. 33, 45-51.
24. Nalbandyan R. M. (1983) Copper in brain. Neurochem. Res. 8, 1211-1232.
25. Pan K. M., Stahl N., and Prusiner S. B. (1992) Purification and properties of the cellular prion protein from Syrian hamster brain. Protein Sci. 1, 1343-1352.
26. Pauly P. C. and Harris D. A. (1998) Copper stimulates endocytosis of the prion protein. J. Biol. Chem. 273, 33,107-33,110.
27. Prusiner S. B. (1998) Prions. Proc. Natl. Acad. Sci. U. S. A. 95, 13363-13383.
28. Sandoval M. E., Horch P., and Cotman C. W. (1978) Evaluation of glutamate as a hippocampal neurotransmitter: glutamate uptake and release from synaptosomes. Brain Res. 142, 285-299.
29. Schaefer M. and Gitlin J. D. (1999) Genetic disorders of membrane transport. IV. Wilson's disease and Menkes disease. Am. J. Physiol. 276, G311-G314.
30. Shmerling D., Hegyi I., Fischer M., Blättler T., Brandner S., Götz J., et al. (1998) Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 93, 203-214.
31. Viles J. H., Cohen F. E., Prusiner S. B., Goodin D. B., Wright P. E., and Dyson H. J. (1999) Copper binding to the prion protein: structural implications of four identical co-operative binding sites. Proc. Natl. Acad. Sci. U. S. A. 96, 2042-2047.
32. Waggoner D. J., Drisaldi B., Bartnikas T. B., Casareno R. L., Prohaska J. R., Gitlin D., and Harris D. A. (2000) Brain copper content and cuproenzyme activity do not vary with prion protein expression level. J. Biol. Chem. 275, 7455-7458.