메뉴 건너뛰기




Volumn 12, Issue 5, 2005, Pages 419-429

Alcoholic and nonalcoholic stimulation of hepatic cytochrome P450 2E1; biochemical, pharmacological and pathophysiological consequences;Alkoholowa i niealkoholowa stymulacja wa̧trobowego cytochromu P450 2E1; konsekwencje biochemiczne, farmakologiczne i patofizjologiczne

Author keywords

Alcohol; CYP2E1; Diabetes; Fatty liver; Hepatotoxicity of drugs; Obesity; Polymorphisms

Indexed keywords

CYTOCHROME P450 2E1; IRON; REACTIVE OXYGEN METABOLITE;

EID: 27644512312     PISSN: 12329886     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (94)
  • 1
    • 0032937986 scopus 로고    scopus 로고
    • The physiological and pharmacological roles of cytochrome P450 isoenzymes
    • Chang G., Kam P.: The physiological and pharmacological roles of cytochrome P450 isoenzymes. Anaesthesia, 1999, 54, 42-50.
    • (1999) Anaesthesia , vol.54 , pp. 42-50
    • Chang, G.1    Kam, P.2
  • 2
    • 0014962167 scopus 로고
    • Hepatic microsomal ethanol-oxidizing system
    • Lieber C., DeCarli L.: Hepatic microsomal ethanol-oxidizing system. J. Biol. Chem., 1970, 245, 2505-2512.
    • (1970) J. Biol. Chem. , vol.245 , pp. 2505-2512
    • Lieber, C.1    Decarli, L.2
  • 3
    • 1642491782 scopus 로고    scopus 로고
    • The unexpected outcomes of medical research: Serendipity and the microsomal ethanol oxidizing system
    • Lieber C.: The unexpected outcomes of medical research: serendipity and the microsomal ethanol oxidizing system. J. Hepatol., 2004, 40, 198-202.
    • (2004) J. Hepatol. , vol.40 , pp. 198-202
    • Lieber, C.1
  • 4
    • 0018873918 scopus 로고
    • Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase
    • Burnett K., Felder M.: Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase. Biochem. Pharmacol., 1980, 29, 125-130.
    • (1980) Biochem. Pharmacol. , vol.29 , pp. 125-130
    • Burnett, K.1    Felder, M.2
  • 5
    • 0022196073 scopus 로고
    • Role of alcohol dehydrogenase in the swift increase in alcohol metabolism (SIAM)
    • Glassman E., McLaughlin G., Forman D., Felder M., Thurman R.: Role of alcohol dehydrogenase in the swift increase in alcohol metabolism (SIAM). Biochem. Pharmacol., 1985, 34, 3523-3526.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3523-3526
    • Glassman, E.1    McLaughlin, G.2    Forman, D.3    Felder, M.4    Thurman, R.5
  • 6
    • 0023261510 scopus 로고
    • Respective roles of the microsomal ethanol oxidizing system and catalase in ethanol metabolism by deermice lacking alcohol dehydrogenase
    • Kato S., Alderman J., Lieber C.: Respective roles of the microsomal ethanol oxidizing system and catalase in ethanol metabolism by deermice lacking alcohol dehydrogenase. Arch. Biochem. Biophys., 1987, 254, 586-591.
    • (1987) Arch. Biochem. Biophys. , vol.254 , pp. 586-591
    • Kato, S.1    Alderman, J.2    Lieber, C.3
  • 8
    • 0036799064 scopus 로고    scopus 로고
    • Metabolizing enzyme localization and activities in the first trimester human placenta: The effect of maternal and gestational age, smoking and alcohol consumption
    • Coolier A., Tingle M., Paxton J., Mitchell M., Keelen J.: Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption. Hum. Reprod., 2002, 10, 2564-2572.
    • (2002) Hum. Reprod. , vol.10 , pp. 2564-2572
    • Coolier, A.1    Tingle, M.2    Paxton, J.3    Mitchell, M.4    Keelen, J.5
  • 9
    • 0036156595 scopus 로고    scopus 로고
    • The ontogeny of human drug-metabolizing enzymes: Phase I oxidative enzymes
    • Mines R.N., McCarver D.G.: The ontogeny of human drug-metabolizing enzymes: Phase I oxidative enzymes. J. Pharmacol. Exp. Ther., 2002, 300, 355-360.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 355-360
    • Mines, R.N.1    McCarver, D.G.2
  • 10
    • 0036265957 scopus 로고    scopus 로고
    • Effect of chronic alcohol consumption on the ethanol- and acetaldehyde-metabolizing systems in the rat gastrointestinal tract
    • Pronko P., Bardina L., Satanowskaya V., Kuzmich A., Zimatkin S.: Effect of chronic alcohol consumption on the ethanol- and acetaldehyde-metabolizing systems in the rat gastrointestinal tract. Alcohol Alcohol., 2002, 37, 229-235.
    • (2002) Alcohol Alcohol , vol.37 , pp. 229-235
    • Pronko, P.1    Bardina, L.2    Satanowskaya, V.3    Kuzmich, A.4    Zimatkin, S.5
  • 11
    • 0036150848 scopus 로고    scopus 로고
    • Pharmacokinetics of ethanol: A review of the methodology
    • Matsumoto H., Fukui Y.: Pharmacokinetics of ethanol: a review of the methodology. Add. Biol., 2002, 7, 5-14.
    • (2002) Add. Biol. , vol.7 , pp. 5-14
    • Matsumoto, H.1    Fukui, Y.2
  • 12
    • 0033053587 scopus 로고    scopus 로고
    • Microsomal ethanol-oxidizing system (MEOS): The first 30 years (1968-1998) - A review
    • Lieber C.: Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998) - a review. Alcohol. Clin. Exp. Res., 1999, 23, 991-1007.
    • (1999) Alcohol. Clin. Exp. Res. , vol.23 , pp. 991-1007
    • Lieber, C.1
  • 13
  • 16
    • 1342323673 scopus 로고    scopus 로고
    • Oxidative stress, toxicology, and pharmacology of CYP2E1
    • Caro A.A., Cederbaum A.I.: Oxidative stress, toxicology, and pharmacology of CYP2E1. Ann. Rev. Pharmacol. Toxicol., 2004, 44, 27-42.
    • (2004) Ann. Rev. Pharmacol. Toxicol. , vol.44 , pp. 27-42
    • Caro, A.A.1    Cederbaum, A.I.2
  • 17
    • 0037525192 scopus 로고    scopus 로고
    • Evidence-based prevention (EBP): Approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism
    • Oyama T., Matsumoto A., Isse T., Kim Y., Ozaki S., Osaki T., Sugio K., Yasumoto K., Kawamoto T.: Evidence-based prevention (EBP): approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism. Anticancer Res., 2003, 23, 1731-1738.
    • (2003) Anticancer Res. , vol.23 , pp. 1731-1738
    • Oyama, T.1    Matsumoto, A.2    Isse, T.3    Kim, Y.4    Ozaki, S.5    Osaki, T.6    Sugio, K.7    Yasumoto, K.8    Kawamoto, T.9
  • 18
    • 0028332490 scopus 로고
    • Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment
    • Kukiełka E., Dicker E., Cederbaum A.: Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment. Arch. Bioch. Biophys., 1994, 309, 377-386.
    • (1994) Arch. Bioch. Biophys. , vol.309 , pp. 377-386
    • Kukiełka, E.1    Dicker, E.2    Cederbaum, A.3
  • 21
    • 0041382561 scopus 로고    scopus 로고
    • Iron and CYP2E1-dependent oxidative stress and toxicity
    • Cederbaum A.: Iron and CYP2E1-dependent oxidative stress and toxicity. Alcohol, 2003, 30, 115-120.
    • (2003) Alcohol , vol.30 , pp. 115-120
    • Cederbaum, A.1
  • 22
    • 0041883466 scopus 로고    scopus 로고
    • Role of iron in alcoholic liver disease: Introduction and summary of the symposium
    • Purohit V., Russo D., Salin M.: Role of iron in alcoholic liver disease: introduction and summary of the symposium. Alcohol, 2003, 30, 93-97.
    • (2003) Alcohol , vol.30 , pp. 93-97
    • Purohit, V.1    Russo, D.2    Salin, M.3
  • 23
    • 0032927195 scopus 로고    scopus 로고
    • Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor
    • Sarich T.C., Adams S.P., Petricca G., Wright J.M.: Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor. J. Pharmacol. Exp. Ther., 1999, 289, 695-702.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 695-702
    • Sarich, T.C.1    Adams, S.P.2    Petricca, G.3    Wright, J.M.4
  • 24
    • 0037380862 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
    • Huang Y., Chern H., Wu J., Chang S., Chiang C., Chang F., Lee S.: Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. Hepatology, 2003, 37, 924-930.
    • (2003) Hepatology , vol.37 , pp. 924-930
    • Huang, Y.1    Chern, H.2    Wu, J.3    Chang, S.4    Chiang, C.5    Chang, F.6    Lee, S.7
  • 26
    • 0030802792 scopus 로고    scopus 로고
    • Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization
    • Chien J.Y., Thummel K.E., Slattery J.T.: Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization. Drug Metab. Dispos., 1997, 25, 1165-1175.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1165-1175
    • Chien, J.Y.1    Thummel, K.E.2    Slattery, J.T.3
  • 27
    • 0035144768 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: Potent inhibition of CYP2C19 and CYP3A
    • Desta Z., Soukhova N.V., Flockhart D.A.: Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A. Antimicrob. Agents Chemother., 2001, 45, 382-392.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 382-392
    • Desta, Z.1    Soukhova, N.V.2    Flockhart, D.A.3
  • 28
    • 0036246916 scopus 로고    scopus 로고
    • Alcohol exposure and paracetamol-induced hepatotoxicity
    • Riordan S., Williams R.: Alcohol exposure and paracetamol-induced hepatotoxicity. Add. Biol., 2002, 7, 191-206.
    • (2002) Add. Biol. , vol.7 , pp. 191-206
    • Riordan, S.1    Williams, R.2
  • 31
    • 0031737607 scopus 로고    scopus 로고
    • A genetic polymorphism in the regulatory sequence of human CYP2E1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake
    • McCarver D., Byun R., Hines R., Hichme M., Wegenek W.: A genetic polymorphism in the regulatory sequence of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. Toxicol. Appl. Pharmacol., 1998, 152, 276-281.
    • (1998) Toxicol. Appl. Pharmacol. , vol.152 , pp. 276-281
    • McCarver, D.1    Byun, R.2    Hines, R.3    Hichme, M.4    Wegenek, W.5
  • 32
    • 0041764982 scopus 로고    scopus 로고
    • CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease
    • Emery M., Fisher J., Chien J., Kharasch, Dellinger P., Kowdley K., Thummel K.: CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatology, 2003, 38, 428-435.
    • (2003) Hepatology , vol.38 , pp. 428-435
    • Emery, M.1    Fisher, J.2    Chien, J.3    Kharasch4    Dellinger, P.5    Kowdley, K.6    Thummel, K.7
  • 33
    • 0141494281 scopus 로고    scopus 로고
    • CYP2E1: Biochemistry, toxicology, regulation and function in ethanol-induced liver injury
    • Kessova I., Cederbaum A.: CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury. Curr. Mol. Med., 2003, 3, 509-518.
    • (2003) Curr. Mol. Med. , vol.3 , pp. 509-518
    • Kessova, I.1    Cederbaum, A.2
  • 34
    • 0028172842 scopus 로고
    • Cytochrome P450 changes in rats with streptozocin-induced diabetes
    • Shimojo N.: Cytochrome P450 changes in rats with streptozocin-induced diabetes. Int. J. Biochem., 1994, 26, 1261-1268.
    • (1994) Int. J. Biochem. , vol.26 , pp. 1261-1268
    • Shimojo, N.1
  • 35
    • 0037241174 scopus 로고    scopus 로고
    • Diabetes mellitus increases the in vivo activity of cytochroms P450 2E1 in humans
    • Wang Z., Hall S., Maya J., Li L., Asghar A., Gorski J.: Diabetes mellitus increases the in vivo activity of cytochroms P450 2E1 in humans. Br. J. Clin. Pharmacol., 2003, 55, 77-85.
    • (2003) Br. J. Clin. Pharmacol. , vol.55 , pp. 77-85
    • Wang, Z.1    Hall, S.2    Maya, J.3    Li, L.4    Asghar, A.5    Gorski, J.6
  • 36
    • 0032821468 scopus 로고    scopus 로고
    • Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity
    • Leclerq I., Horsmans Y., Desager J.P., Pauwels S., Geubel A.P.: Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity. Br. J. Nutr., 1999, 82, 257-262.
    • (1999) Br. J. Nutr. , vol.82 , pp. 257-262
    • Leclerq, I.1    Horsmans, Y.2    Desager, J.P.3    Pauwels, S.4    Geubel, A.P.5
  • 37
  • 38
    • 0742271378 scopus 로고    scopus 로고
    • Common pathogenic mechanisms in ASH and NASH
    • Ishii H.: Common pathogenic mechanisms in ASH and NASH. Hepatol. Res., 2004, 28, 18-20.
    • (2004) Hepatol. Res. , vol.28 , pp. 18-20
    • Ishii, H.1
  • 39
    • 0742306111 scopus 로고    scopus 로고
    • CYP2E1: From ASH to NASH
    • Lieber C.: CYP2E1: from ASH to NASH. Hepatol. Res., 2004, 28, 1-11.
    • (2004) Hepatol. Res. , vol.28 , pp. 1-11
    • Lieber, C.1
  • 40
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P 450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • Weltman M.D., Farrel G.C., Hall P., Ingelman-Sundenberg M., Liddle C.: Hepatic cytochrome P 450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology, 1998, 27, 128-133.
    • (1998) Hepatology , vol.27 , pp. 128-133
    • Weltman, M.D.1    Farrel, G.C.2    Hall, P.3    Ingelman-Sundenberg, M.4    Liddle, C.5
  • 41
    • 0029829455 scopus 로고    scopus 로고
    • Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
    • Weltman M.D., Farrel G.C., Liddle C.: Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology, 1996, 111, 1645-1653.
    • (1996) Gastroenterology , vol.111 , pp. 1645-1653
    • Weltman, M.D.1    Farrel, G.C.2    Liddle, C.3
  • 42
    • 0037369729 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
    • Chalasani N., Gorski J.C., Asghar M., Asghar A., Foresman B., Hall S.D., Crabb D.: Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology, 2003, 37, 544-550.
    • (2003) Hepatology , vol.37 , pp. 544-550
    • Chalasani, N.1    Gorski, J.C.2    Asghar, M.3    Asghar, A.4    Foresman, B.5    Hall, S.D.6    Crabb, D.7
  • 44
    • 0031756902 scopus 로고    scopus 로고
    • Regulation of rabbit cytochrome P450 2E1 expression in HepG2 cells by insulin and thyroid hormone
    • Peng H.-M., Coon M.J.: Regulation of rabbit cytochrome P450 2E1 expression in HepG2 cells by insulin and thyroid hormone. Mol. Pharmacol., 1998, 54, 740-747.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 740-747
    • Peng, H.-M.1    Coon, M.J.2
  • 45
    • 0026773423 scopus 로고
    • Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes
    • Eliasson E., Mkrtchian S., Ingelman-Sundberg M.: Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes. J. Biol. Chem., 1992, 267, 15765-15769.
    • (1992) J. Biol. Chem. , vol.267 , pp. 15765-15769
    • Eliasson, E.1    Mkrtchian, S.2    Ingelman-Sundberg, M.3
  • 46
    • 0026060702 scopus 로고
    • Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes
    • Johansson E., Eliasson E., Ingelman-Sundberg M.: Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes. Biochem. Biophys. Res. Commun., 1991, 174, 37-42.
    • (1991) Biochem. Biophys. Res. Commun. , vol.174 , pp. 37-42
    • Johansson, E.1    Eliasson, E.2    Ingelman-Sundberg, M.3
  • 47
    • 0028931737 scopus 로고
    • Gender-related differences in susceptibility to acetaminophen-induced protein arylation and nephrotoxicity in CD-1 mouse
    • Hoivik D.J., Manautou J.E., Tveit A., Hart S.G., Khairallah E.A., Cohen S.D.: Gender-related differences in susceptibility to acetaminophen-induced protein arylation and nephrotoxicity in CD-1 mouse. Toxicol. Appl. Pharmacol., 1995, 130, 257-271.
    • (1995) Toxicol. Appl. Pharmacol. , vol.130 , pp. 257-271
    • Hoivik, D.J.1    Manautou, J.E.2    Tveit, A.3    Hart, S.G.4    Khairallah, E.A.5    Cohen, S.D.6
  • 48
    • 1842480297 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction
    • Adams L.A., Feldstein A., Lindor K.D., Angulo P.: Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology, 2004, 3, 909-914.
    • (2004) Hepatology , vol.3 , pp. 909-914
    • Adams, L.A.1    Feldstein, A.2    Lindor, K.D.3    Angulo, P.4
  • 51
    • 0025160864 scopus 로고
    • Inhibition of ethanol-inducible cytochrome P450 IIE1 by 3-amino-1,2,4-triazole
    • Koop D.R.: Inhibition of ethanol-inducible cytochrome P450 IIE1 by 3-amino-1,2,4-triazole. Chem. Res. Toxicol., 1990, 3, 377-383.
    • (1990) Chem. Res. Toxicol. , vol.3 , pp. 377-383
    • Koop, D.R.1
  • 53
    • 0030815178 scopus 로고    scopus 로고
    • Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans
    • Gebhardt A., Lucas D., Menez J., Seitz H.: Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Hepatology, 1997, 26, 957-961.
    • (1997) Hepatology , vol.26 , pp. 957-961
    • Gebhardt, A.1    Lucas, D.2    Menez, J.3    Seitz, H.4
  • 54
    • 0008060930 scopus 로고
    • Inhibition of CYP2E1 in rat liver microsomes by dichloroethylene isomers
    • Thornton-Manning J.R., Lilly P.D., Anderson M.E.: Inhibition of CYP2E1 in rat liver microsomes by dichloroethylene isomers. Toxicologist, 1994, 14, 54.
    • (1994) Toxicologist , vol.14 , pp. 54
    • Thornton-Manning, J.R.1    Lilly, P.D.2    Anderson, M.E.3
  • 55
    • 0032977948 scopus 로고    scopus 로고
    • Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6 and 3A4 activities: Evidence for specificity toward P-450 2E1
    • Kharasch E., Hankins D., Jubert C., Thummel K., Tarady J.: Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6 and 3A4 activities: evidence for specificity toward P-450 2E1. Drug Metab. Dispos., 1999, 27, 717-723.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 717-723
    • Kharasch, E.1    Hankins, D.2    Jubert, C.3    Thummel, K.4    Tarady, J.5
  • 56
    • 0030670952 scopus 로고    scopus 로고
    • Pretranslational and posttranslational regulation of rat hepatic CYPs3A2 and 2E1 by sulfiram
    • Martini R., Ingelman-Sundberg M., Murray M.: Pretranslational and posttranslational regulation of rat hepatic CYPs3A2 and 2E1 by sulfiram. Biochem. Pharmacol., 1997, 54, 1323-1329.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 1323-1329
    • Martini, R.1    Ingelman-Sundberg, M.2    Murray, M.3
  • 57
    • 0030884270 scopus 로고    scopus 로고
    • Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats
    • Navder K.P., Baraona E., Lieber C.S.: Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. J. Nutr., 1997, 127, 1800-1806.
    • (1997) J. Nutr. , vol.127 , pp. 1800-1806
    • Navder, K.P.1    Baraona, E.2    Lieber, C.S.3
  • 58
    • 0036296778 scopus 로고    scopus 로고
    • Dilinoleoylphosphatidylcholine is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats
    • Navder K.P., Lieber C.S.: Dilinoleoylphosphatidylcholine is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats. Biochem. Biophys. Res. Commun., 2002, 291, 1109-1112.
    • (2002) Biochem. Biophys. Res. Commun. , vol.291 , pp. 1109-1112
    • Navder, K.P.1    Lieber, C.S.2
  • 59
    • 0035188749 scopus 로고    scopus 로고
    • Genetic polymorphism of alcohol metabolizing enzymes
    • Agarwal D.: Genetic polymorphism of alcohol metabolizing enzymes. Pathol. Biol., 2001, 49, 703-709.
    • (2001) Pathol. Biol. , vol.49 , pp. 703-709
    • Agarwal, D.1
  • 62
    • 0034028061 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: A study and literature review, including meta-analysis
    • Wong N., Rae F., Simpson K., Murray G., Harrison D.: Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: a study and literature review, including meta-analysis. J. Clin. Pathol. Mol. Pathol., 2000, 53, 88-93.
    • (2000) J. Clin. Pathol. Mol. Pathol. , vol.53 , pp. 88-93
    • Wong, N.1    Rae, F.2    Simpson, K.3    Murray, G.4    Harrison, D.5
  • 64
    • 0033829409 scopus 로고    scopus 로고
    • Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene
    • Inoue K., Yamazaki H., Shimada T.: Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene. Arch. Toxicol., 2000, 74, 372-378.
    • (2000) Arch. Toxicol. , vol.74 , pp. 372-378
    • Inoue, K.1    Yamazaki, H.2    Shimada, T.3
  • 66
    • 0032878589 scopus 로고    scopus 로고
    • Cyclin D1, glutathione S-transferase and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: Assesment of importance of individual genes using multivariant analysis
    • Matthias C., Jahnke V., Jones P.W., Hoban P.R., Alldersea J.E., Worral S.F., Fryer A.A., Strange R.C.: Cyclin D1, glutathione S-transferase and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assesment of importance of individual genes using multivariant analysis. Cancer Epidemiol. Biomarkers. Prev., 1999, 8, 815-823.
    • (1999) Cancer Epidemiol. Biomarkers. Prev. , vol.8 , pp. 815-823
    • Matthias, C.1    Jahnke, V.2    Jones, P.W.3    Hoban, P.R.4    Alldersea, J.E.5    Worral, S.F.6    Fryer, A.A.7    Strange, R.C.8
  • 69
    • 0036223994 scopus 로고    scopus 로고
    • Polymorphism in alcohol-metabolizing enzymes, glutatione S-transferases and apolipoprotein e and susceptibility to alcohol-induced cirrosis and chronic pancreatitis
    • Frenzer A., Butler W., Norton J., Wilson J., Apte M., Pirola R., Ryan P., Roberts-Thomson J.: Polymorphism in alcohol-metabolizing enzymes, glutatione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrosis and chronic pancreatitis. J. Gastroenterol. Hepatol., 2002, 17, 177-182.
    • (2002) J. Gastroenterol. Hepatol. , vol.17 , pp. 177-182
    • Frenzer, A.1    Butler, W.2    Norton, J.3    Wilson, J.4    Apte, M.5    Pirola, R.6    Ryan, P.7    Roberts-Thomson, J.8
  • 70
    • 0035987174 scopus 로고    scopus 로고
    • Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population
    • Hamdy I., Hiratsuka M., Narahara K., El-Enany M., Moursi N., Ahmed M., Mizugaki M.: Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population. Br. J. Clin. Pharmacol., 2002, 53, 596-603.
    • (2002) Br. J. Clin. Pharmacol. , vol.53 , pp. 596-603
    • Hamdy, I.1    Hiratsuka, M.2    Narahara, K.3    El-Enany, M.4    Moursi, N.5    Ahmed, M.6    Mizugaki, M.7
  • 73
    • 0034834786 scopus 로고    scopus 로고
    • Expression of cytochrome P4502E1 in human liver: Relationship between genotype and phenotype in Chinese
    • Tan W., Wu J., Tang H., Lin D.: Expression of cytochrome P4502E1 in human liver: relationship between genotype and phenotype in Chinese. Sci. China, 2001, 44, 356-364.
    • (2001) Sci. China , vol.44 , pp. 356-364
    • Tan, W.1    Wu, J.2    Tang, H.3    Lin, D.4
  • 74
    • 0036832515 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP2E1 gene and susceptibility to Parkinson's in Taiwanese
    • Wu R., Cheng C., Chen K., Shan D., Kuo J., Ho Y., Chern H.: Genetic polymorphism of CYP2E1 gene and susceptibility to Parkinson's in Taiwanese. J. Neural. Transm., 2002, 109, 1403-1414.
    • (2002) J. Neural. Transm. , vol.109 , pp. 1403-1414
    • Wu, R.1    Cheng, C.2    Chen, K.3    Shan, D.4    Kuo, J.5    Ho, Y.6    Chern, H.7
  • 75
    • 0033048246 scopus 로고    scopus 로고
    • Genetic and dietary predictors of CYP2E1 activity: A phenotyping study in Hawaii Japanese using chlorzoxazone
    • Le Marchand L., Wilkinson G., Wilkens L.: Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol. Biomarkers. Prev., 1999, 8, 495-500.
    • (1999) Cancer Epidemiol. Biomarkers. Prev. , vol.8 , pp. 495-500
    • Le Marchand, L.1    Wilkinson, G.2    Wilkens, L.3
  • 78
    • 10744232712 scopus 로고    scopus 로고
    • Gastic cancer: Genetic suscebtibility. Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans
    • Park G., Lee O., Kwon S., Lee C., Yoon B., Hahm J., Lee M., Lee D., Kee C., Sun H.: Gastic cancer: genetic suscebtibility. Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans. J. Gastroenterol. Hepatol., 2003, 18, 1257-1263.
    • (2003) J. Gastroenterol. Hepatol. , vol.18 , pp. 1257-1263
    • Park, G.1    Lee, O.2    Kwon, S.3    Lee, C.4    Yoon, B.5    Hahm, J.6    Lee, M.7    Lee, D.8    Kee, C.9    Sun, H.10
  • 79
    • 0028024393 scopus 로고
    • Ethnic variation in CYP2E1 gene: Polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese
    • Stephens E.A., Taylor J.A., Kaplan Y., Yang C.H., Hsieh L.L., Lucier G.W., Bell D.A.: Ethnic variation in CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese. Pharmacogenetics, 1994, 4, 185-192.
    • (1994) Pharmacogenetics , vol.4 , pp. 185-192
    • Stephens, E.A.1    Taylor, J.A.2    Kaplan, Y.3    Yang, C.H.4    Hsieh, L.L.5    Lucier, G.W.6    Bell, D.A.7
  • 80
    • 0032250312 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans
    • Wan Y.-J., Poland R., Lin K.-M.: Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans. Genet. Test., 1998, 2, 79-83.
    • (1998) Genet. Test. , vol.2 , pp. 79-83
    • Wan, Y.-J.1    Poland, R.2    Lin, K.-M.3
  • 81
    • 0038010430 scopus 로고    scopus 로고
    • CYP2E1*1D regulatory polymorphism: Association with alcohol and nicotine dependence
    • Howard L., Ahluwalia J., Lin S.-K., Sellers E., Tyndale R.: CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence. Pharmacogenetics, 2003, 13, 321-328.
    • (2003) Pharmacogenetics , vol.13 , pp. 321-328
    • Howard, L.1    Ahluwalia, J.2    Lin, S.-K.3    Sellers, E.4    Tyndale, R.5
  • 82
    • 0030749790 scopus 로고    scopus 로고
    • CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan
    • Hildesheim A., Anderson L., Chen C. J., Cheng Y.-J.: CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J. Natl. Cancer Inst., 1997, 89, 1207-1212.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 1207-1212
    • Hildesheim, A.1    Anderson, L.2    Chen, C.J.3    Cheng, Y.-J.4
  • 83
    • 0036637691 scopus 로고    scopus 로고
    • Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem of drinking behavior in middle-aged Japanese men
    • Sun F., Tsuritani I., Yamada Y.: Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem of drinking behavior in middle-aged Japanese men. Behav. Genet., 2002, 32, 229-236.
    • (2002) Behav. Genet. , vol.32 , pp. 229-236
    • Sun, F.1    Tsuritani, I.2    Yamada, Y.3
  • 85
    • 0035985011 scopus 로고    scopus 로고
    • Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers
    • Yamada Y., Sun F., Tsuritani I., Honda R.: Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers. J. Hum. Hypertens., 2002, 16, 479-486.
    • (2002) J. Hum. Hypertens. , vol.16 , pp. 479-486
    • Yamada, Y.1    Sun, F.2    Tsuritani, I.3    Honda, R.4
  • 86
    • 0036024246 scopus 로고    scopus 로고
    • Folate deficiency, methionine metabolism and alcoholic liver disease
    • Halsted C.H., Villanueva J.A., Devlin A.M.: Folate deficiency, methionine metabolism and alcoholic liver disease. Alcohol, 2002, 27, 169-172.
    • (2002) Alcohol , vol.27 , pp. 169-172
    • Halsted, C.H.1    Villanueva, J.A.2    Devlin, A.M.3
  • 87
    • 0033977384 scopus 로고    scopus 로고
    • Alcohol and the liver: Metabolism of alcohol and its role in hepatic and extrahepatic disease
    • Lieber C.: Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic disease. Mt Sinai J. Med., 2000, 67, 84-94.
    • (2000) Mt Sinai J. Med. , vol.67 , pp. 84-94
    • Lieber, C.1
  • 88
    • 0035178103 scopus 로고    scopus 로고
    • Alcoholic liver injury: Pathogenesis and therapy in 2001
    • Lieber C.: Alcoholic liver injury: pathogenesis and therapy in 2001. Pathol. Biol., 2001, 49, 738-752.
    • (2001) Pathol. Biol. , vol.49 , pp. 738-752
    • Lieber, C.1
  • 89
    • 1442282934 scopus 로고    scopus 로고
    • New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments
    • Lieber C.: New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. Curr. Gastroenterol. Rep., 2004, 6, 60-65.
    • (2004) Curr. Gastroenterol. Rep. , vol.6 , pp. 60-65
    • Lieber, C.1
  • 90
    • 0036315905 scopus 로고    scopus 로고
    • Gastric alcohol dehydrogenase activity in man: Influence of gender, sex, alcohol consumption and smoking in a Caucasian population
    • Parlesak A., Billinger M., Bode C., Bode J.: Gastric alcohol dehydrogenase activity in man: influence of gender, sex, alcohol consumption and smoking in a Caucasian population. Alcohol Alcohol., 2002, 4, 388-393.
    • (2002) Alcohol Alcohol , vol.4 , pp. 388-393
    • Parlesak, A.1    Billinger, M.2    Bode, C.3    Bode, J.4
  • 92
    • 10644277012 scopus 로고    scopus 로고
    • The management of alcohol liver disease
    • Stewart S., Day C.: The management of alcohol liver disease. J. Hepatol., 2003, 38, S2-S13.
    • (2003) J. Hepatol. , vol.38
    • Stewart, S.1    Day, C.2
  • 93
    • 0031012252 scopus 로고    scopus 로고
    • Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patiens
    • Chao Y.-C., Young T.-H., Tang H.-S., Hsu C.-T.: Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patiens. Hepatology, 1997, 25, 112-117.
    • (1997) Hepatology , vol.25 , pp. 112-117
    • Chao, Y.-C.1    Young, T.-H.2    Tang, H.-S.3    Hsu, C.-T.4
  • 94
    • 0042659736 scopus 로고    scopus 로고
    • Genetic polymorphisms of tabacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma
    • Munaka M., Kohsi K., Kawamoto T., Takasawa S., Nagata N., Itoh H., Oda S., Katoh T.: Genetic polymorphisms of tabacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma. J. Cancer Res. Clin. Oncol., 2003, 129, 355-360.
    • (2003) J. Cancer Res. Clin. Oncol. , vol.129 , pp. 355-360
    • Munaka, M.1    Kohsi, K.2    Kawamoto, T.3    Takasawa, S.4    Nagata, N.5    Itoh, H.6    Oda, S.7    Katoh, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.