Differential p70S6k and 4E-BP1 regulation by insulin and amino acids in vascular endothelial and smooth muscle cells

Acta Diabetologica

Volumn 42, Issue 3, 2005, Pages 139-146

  Terruzzi, I ^a   Pellegatta, F ^a,b   Luzi, L ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

4E BP1; Amino acids; Human vascular cells; Insulin; p70S6k

Indexed keywords

AMINO ACID DERIVATIVE; BRANCHED CHAIN AMINO ACID; INITIATION FACTOR 4E BINDING PROTEIN 1; NEUTRAL INSULIN; S6 KINASE;

ARTICLE; ATHEROGENESIS; CELL FREE SYSTEM; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN SYNTHESIS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; SMOOTH MUSCLE FIBER; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACIDS, BRANCHED-CHAIN; CARRIER PROTEINS; CELL LINE; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; INSULIN; MUSCLE, SMOOTH, VASCULAR; PHOSPHOPROTEINS; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

EID: 27644512272     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-005-0193-z     Document Type: Article

References (39)

1. Ross R (1995) Cell biology of atherosclerosis. Annu Rev Physiol 57:791-804
2. Stenmark KR, Mecham RP (1997) Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol 59:89-144
3. Millward DJ, Fereday A, Gibson NR, Pacy PJ (1996) Postprandial protein metabolism. Baillieres Clin Endocrinol Metab 10:533-549
4. Tessari P, Barazzoni R, Zanetti M, Kiwanuka E, Tiengo A (1996) The role of substrates in the regulation of protein metabolism. Baillieres Clin Endocrinol Metab 10:511-532
5. Tessari P, Zanetti M, Barazzoni R, Vettore M, Michielan F (1996) Mechanisms of postprandial protein accretion in human skeletal muscle. Insight from leucine and phenylalanine forearm kinetics. J Clin Invest 98:1361-1372
6. Shah OJ, Anthony JC, Kimball SR, Jefferson ES (2000) 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. Am J Physiol Endocrinol Metab 279:E715-E729
7. Harada H, Andersen JS, Mann M, Terada N, Korsmeyer SJ (2001) p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci USA 98:9666-9670
8. Volarevic S, Thomas G (2001) Role of S6 phosphorylation and S6 kinase in cell growth. Prog Nucleic Acid Res Mol Biol 65:101-127
9. Bommer UA, Noll F, Lutsch G, Bielka H (1980) Immunochemical detection of proteins in the small subunit of rat liver ribosomes involved in binding of the ternary initiation complex. FEBS Lett 111:171-174
10. Terao K, Ogata K (1979) Proteins of small subunits of rat liver ribosomes that interact with poly(U). II. Cross-links between poly(U) and ribosomal proteins in 40 S subunits induced by UV irradiation. J Biochem 86:605-617
11. Jefferies HB, Fumagalli S, Dennis PB, Reinhard C, Pearson RB, Thomas G (1997) Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO J 16:3693-3704
12. Pain VM (1996) Initiation of protein synthesis in eukaryotic cells. Eur J Biochem 236:747-771
13. Kozak M (1999) Initiation of translation in prokaryotes and eukaryotes. Gene 234:187-208
14. Kimball SR, Vary TC, Jefferson LS (1994) Regulation of protein synthesis by insulin. Annu Rev Physiol 56:321-348
15. O'Brien RM, Granner DK (1996) Regulation of gene expression by insulin. Physiol Rev 76:1109-1161
16. Kimball SR, Yancisin M, Horetsky RL, Jefferson LS (1996) Translational and pretranslational regulation of protein synthesis by amino acid availability in primary cultures of rat hepatocytes. Int J Biochem Cell Biol 28:285-294
17. Castellino P, Luzi L, Simonson DC, Haymond M, DeFronzo RA (1987) Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis. J Clin Invest 80:1784-1793
18. Wang X, Campbell LE, Miller CM, Proud CG (1998) Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem J 334:261-267
19. May ME, Buse MG (1989) Effects of branched-chain amino acids on protein turnover. Diabetes Metab Rev 5:227-245
20. Louard RJ, Barrett EJ, Gelfand RA (1995) Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis. Metabolism 44:424-429
21. Liu Z, Jahn LA, Long W, Fryburg DA, Wei L, Barrett EJ (2001) Branched chain amino acids activate messenger ribonucleic acid translation regulatory proteins in human skeletal muscle, and glucocorticoids blunt this action. J Clin Endocrinol Metab 86:2136-2143
22. Long W, Saffer L, Wei L, Barrett EJ (2000) Amino acids regulate skeletal muscle PHAS-I and p70S6-kinase phosphorylation independently of insulin. Am J Physiol Endocrinol Metab 279:E301-306
23. Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR (1998) Bidirectional modulation of insulin action by amino acids. J Clin Invest 101:1519-1529
24. Balage M, Sinaud S, Prod'homme M, Dardevet D, Vary TC, Kimball SR, Jefferson LS, Grizard J (2001) Amino acids and insulin are both required to regulate assembly of the eIF4E-eIF4G complex in rat skeletal muscle. Am J Physiol Endocrinol Metab 281:565-574
25. Jaffe EA, Nachman RL, Becker CG, Minick CR (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:2745-2756
26. Gimbrone MA Jr, Cotran RS (1975) Human vascular smooth muscle in culture. Growth and ultrastructure. Lab Invest 33:16-27
27. Pullen N, Thomas G (1997) The modular phosphorylation and activation of p70S6k. FEBS Lett 410:78-82
28. Shepherd PR, Withers DJ, Siddle K (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333:471-490
29. Fadden P, Haystead TA, Lawrence JC Jr (1997) Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. J Biol Chem 272:10240-10247
30. Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R, Sonenberg N (2001) Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev 15:2852-2864
31. Buse MG (1981) In vivo effects of branched chain amino acids on muscle protein synthesis in fasted rats. Horm Metab Res 13:502-505
32. Herbert TP, Tee AR, Proud CG (2002) The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J Biol Chem 277:11591-11596
33. Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J (1998) Amino acid sufficiency and mTOR regulate p70S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273:14484-14494
34. Yoshizawa F, Kimball SR, Jefferson LS (1997) Modulation of translation initiation in rat skeletal muscle and liver in response to food intake. Biochem Biophys Res Commun 240:825-831
35. Fulks RM, Li JB, Goldberg AL (1975) Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem 250:290-298
36. Kimball SR (2002) Regulation of global and specific mRNA translation by amino acids. J Nutr 132:883-886
37. Jefferies HB, Reinhard C, Kozma SC, Thomas G (1994) Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci USA 91:4441-4445
38. Jefferies HB, Thomas G, Thomas G (1994) Elongation factor-1 alpha mRNA is selectively translated following mitogenic stimulation. J Biol Chem 269:4367-4372
39. Thomas G, Thomas G (1986) Translational control of mRNA expression during the early mitogenic response in Swiss mouse 3T3 cells: identification of specific proteins. J Cell Biol 103:2137-2144