Novel type of hepatitis B virus mutation: Replacement mutation involving a hepatocyte nuclear factor 1 binding site tandem repeat in chronic hepatitis B virus genotype E

Journal of Virology

Volumn 79, Issue 22, 2005, Pages 14404-14410

  Fujiwara, Kei ^a   Tanaka, Yasuhito ^a   Paulon, Emma ^b   Orito, Etsuro ^a   Sugiyama, Masaya ^a   Ito, Kiyoaki ^a   Ueda, Ryuzo ^a   Mizokami, Masashi ^a   Naoumov, Nikolai V ^b  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS E ANTIGEN; NUCLEAR FACTOR I; NUCLEOCAPSID PROTEIN; TRANSCRIPTION FACTOR; VIRUS DNA;

ADULT; ARTICLE; BINDING SITE; BLOOD LEVEL; CLINICAL ARTICLE; CLONE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE DELETION; GENE DUPLICATION; GENE INSERTION; GENE SEQUENCE; GENETIC RECOMBINATION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER FIBROSIS; LONGITUDINAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REPLICON; TANDEM REPEAT; VIRUS MUTANT; VIRUS MUTATION; VIRUS STRAIN; WILD TYPE;

BASE SEQUENCE; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL LINE; CLONING, ORGANISM; DNA TRANSPOSABLE ELEMENTS; DNA, VIRAL; GENE AMPLIFICATION; GENOTYPE; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS);

DNA VIRUSES; HEPATITIS B VIRUS;

EID: 27644509155     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.22.14404-14410.2005     Document Type: Article

References (44)

1. Abe, A., K. Inoue, T. Tanaka, J. Kato, N. Kajiyama, R. Kawaguchi, S. Tanaka, M. Yoshiba, and M. Kohara. 1999. Quantitation of hepatitis B virus genomic DNA by real-time detection PCR. J. Clin. Microbiol. 37:2899-2903.
2. Ahn, S. H., A. Kramvis, S. Kawai, H. C. Spangenberg, J. Li, G. Kimbi, M. Kew, J. Wands, and S. Tong. 2003. Sequence variation upstream of precore translation initiation codon reduces hepatitis B virus e antigen production. Gastroenterology 125:1370-1378.
3. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
4. Bhat, R. A., P. P. Ulrich, and G. N. Vyas. 1990. Molecular characterization of a new variant of hepatitis B virus in a persistently infected homosexual man. Hepatology 11:271-276.
5. Blum, H. E., Z. -S. Zhang, E. Galun, F. von Weizsäcker, B. Garner, T. J. Liang, and J. R. Wands. 1992. Hepatitis B virus X protein is not central to the viral life cycle in vitro. J. Virol. 66:1223-1227.
6. Conway, J. F., N. R. Watts, D. M. Belnap, N. Cheng, S. J. Stahl, P. T. Wingfield, and A. C. Steven. 2003. Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding. J. Virol. 77:6466-6473.
7. Erhardt, A., U. Reineke, D. Blondin, W. H. Gerlich, O. Adams, T. Heintges, C. Niederau, and D. Haussinger. 2000. Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B. Hepatology 31:716-725.
8. Fields, B. N., D. M. Knipe, P. M. Howley, and D. E. Griffin. 2001. Fields virology, 4th ed. Lippincott Williams & Wilkins, Philadelphia, Pa.
9. Fujiwara, K., Y. Tanaka, E. Orito, T. Ohno, T. Kato, F. Sugauchi, S. Suzuki, Y. Hattori, M. Sakurai, I. Hasegawa, T. Ozasa, F. Kanie, H. Kano, R. Ueda, and M. Mizokami. 2004. Lack of association between occult hepatitis B virus DNA viral load and aminotransferase levels in patients with hepatitis C virus-related chronic liver disease. J. Gastroenterol. Hepatol. 19:1343-1347.
10. Günther, S., N. Piwon, A. Iwanska, R. Schilling, H. Meisel, and H. Will. 1996. Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease. J. Virol. 70:8318-8331.
11. Gunther, S., N. Piwon, A. Jung, A. Iwanska, H. Schmitz, and H. Will. 2000. Enhanced replication contributes to enrichment of hepatitis B virus with a deletion in the core gene. Virology 273:286-299.
12. Hannoun, C., P. Horal, K. Krogsgaard, and M. Lindh. 2002. Mutations in the X region and core promoter are rare and have little impact on response to interferon therapy for chronic hepatitis B. J. Med. Virol. 66:171-178.
13. Iavarone, M., J. B. Trabut, O. Delpuech, F. Carnot, M. Colombo, D. Kremsdorf, C. Brechot, and V. Thiers. 2003. Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection. J. Hepatol. 39:253-261.
14. Ishak. K. G. 1994. Chronic hepatitis: morphology and nomenclature. Mod. Pathol. 7:690-713.
15. Kato, H., E. Orito, R. G. Gish, N. Bzowej, M. Newsom, F. Sugauchi, S. Suzuki, R. Ueda, Y. Miyakawa, and M. Mizokami. 2002. Hepatitis B e antigen in sera from individuals infected with hepatitis B virus of genotype G. Hepatology 35:922-929.
16. Kramvis, A., and M. C. Kew. 1998. Structure and function of the encapsidation signal of hepadnaviridae. J. Viral Hepat. 5:357-367.
17. Kramvis, A., L. Weitzmann, W. K. Owiredu, and M. C. Kew. 2002. Analysis of the complete genome of subgroup A' hepatitis B virus isolates from South Africa. J. Gen. Virol. 83:835-839.
18. Kuwahara, R., R. Kumashiro, S. Murashima, K. Ogata, K. Tanaka, A. Hisamochi, T. Hino, T. Ide, E. Tanaka, Y. Koga, and M. Sata. 2004. Genetic heterogeneity of the precore and the core promoter region of genotype C hepatitis B virus during lamivudine therapy. J. Med. Virol. 72:26-34.
19. Laskus, T., J. Rakela, J. L. Steers, R. H. Wiesner, and D. H. Persing. 1994. Precore and contiguous regions of hepatitis B virus in liver transplantation for end-stage hepatitis B. Gastroenterology 107:1774-1780.
20. Laskus, T., J. Rakela, M. J. Tong, M. J. Nowicki, J. W. Mosley, and D. H. Persing. 1994. Naturally occurring hepatitis B virus mutants with deletions in the core promoter region. J. Hepatol. 20:837-841.
21. Li, J., V. E. Buckwold, M.-W. Hon, and J.-H. Ou. 1999. Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation. J. Virol. 73:1239-1244.
22. Naoumov, N. V., B. C. Portmann, R. S. Tedder, B. Ferns, A. L Eddleston, G. J. Alexander, and R. Williams. 1990. Detection of hepatitis B virus antigens in liver tissue. A relation to viral replication and histology in chronic hepatitis B infection. Gastroenterology 99:1248-1253.
23. Naoumov, N. V., K. A. Antonov, S. Miska, V. Bichko, R. Williams, and H. Will. 1997. Differentiation of core gene products of the hepatitis B virus in infected liver tissue using monoclonal antibodies. J. Med. Virol. 53:127-138.
24. Okamoto, H., F. Tsuda, Y. Akahane, Y. Sugai, M. Yoshiba, K. Moriyama, T. Tanaka, Y. Miyakawa, and M. Mayumi. 1994. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J. Virol. 68:8102-8110.
25. Okamoto, H., F. Tsuda, H. Sakugawa, R. I. Sastrosoewignjo, M. Imai, Y. Miyakawa, and M. Mayumi. 1988. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J. Gen. Virol. 69:2575-2583.
26. Orito, E., M. Mizokami, H. Sakugawa, K. Michitaka, K. Ishikawa, T. Ichida, T. Okanoue, H. Yotsuyanagi, S. Iino, et al. 2001. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Hepatology 33:218-223.
27. Pollicino, T., S. Campo, and G. Raimondo. 1995. PreS and core gene heterogeneity in hepatitis B virus (HBV) genomes isolated from patients with long-lasting HBV chronic infection. Virology 208:672-677.
28. Pourcel, C., A. Louise, M. Gervais, N. Chenciner, M.-F. Dubois, and P. Tiollais. 1982. Transcription of the hepatitis B surface antigen gene in mouse cells transformed with cloned viral DNA. J. Virol. 42:100-105.
29. Poussin, K., H. Dienes, H. Sirma, S. Urban, M. Beaugrand, D. Franco, P. Schirmacher, C. Brechot, and P. Paterlini Brechot. 1999. Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas. Int. J. Cancer 80:497-505.
30. Pult, I., T. Chouard, S. Wieland, R. Klemenz, M. Yaniv, and H. E. Blum. 1997. A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B. Hepatology 25:1507-1515.
31. Raney, A. K., A. J. Easton, and A. McLachlan. 1994. Characterization of the minimal elements of the hepatitis B virus large surface antigen promoter. J. Gen. Virol. 75:2671-2679.
32. Raney, A. K., D. R. Milich, A. J. Easton, and A. McLachlan. 1990. Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines. J. Virol. 64:2360-2368.
33. Siddiqui, A., S. Jameel, and J. Mapoles. 1987. Expression of the hepatitis B virus X gene in mammalian cells. Proc. Natl. Acad. Sci. USA 84:2513-2517.
34. Stuyver, L., S. De Gendt, C. Van Geyt, F. Zoulim, M. Fried, R. F. Schinazi, and R. Rossau. 2000. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J. Gen. Virol. 81:67-74.
35. Sugauchi, F., H. Kumada, S. A. Acharya, S. M. Shrestha, M. T. Gamutan, M. Khan, R. G. Gish, Y. Tanaka, T. Kato, E. Orito, R. Ueda, Y. Miyakawa, and M. Mizokami. 2004. Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A. J. Gen. Virol. 85:811-820.
36. Sugauchi, F., M. Mizokami, E. Orito, T. Ohno, H. Kato, S. Suzuki, Y. Kimura, R. Ueda, L. A. Butterworth, and W. G. Cooksley. 2001. A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness. J. Gen. Virol. 82:883-892.
37. Sugauchi, F., T. Ohno, E. Orito, H. Sakugawa, T. Ichida, M. Komatsu, T. Kuramitsu, R. Ueda, Y. Miyakawa, and M. Mizokami. 2003. Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease. J. Med. Virol. 70:537-544.
38. Tanaka, Y., I. Hasegawa, T. Kato, E. Orito, N. Hirashima, S. K. Acharya, R. G. Gish, A. Kramvis, M. C. Kew, N. Yoshihara, S. M. Shrestha, M. Khan, Y. Miyakawa, and M. Mizokami. 2004. A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and D. Hepatology 40:747-755.
39. Tang, H., L. Delgermaa, F. Huang, N. Oishi, L. Liu, F. He, L. Zhao, and S. Murakami. 2005. The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J. Virol. 79:5548-5556.
40. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
41. Turelli, P., B. Mangeat, S. Jost, S. Vianin, and D. Trono. 2004. Inhibition of hepatitis B virus replication by APOBEC3G. Science 303:1829.
42. Wai, C. T., C. J. Chu, M. Hussain, and A. S. Lok. 2002. HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C. Hepatology 36:1425-1430.
43. Wakita, T., S. Kakumu, M. Shibata, K. Yoshioka, Y. Ito, T. Shinagawa, T. Ishikawa, M. Takayanagi, and T. Morishima. 1991. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J. Clin. Investig. 88:1793-1801.
44. Webby, R., E. Hoffmann, and R. Webster. 2004. Molecular constraints to interspecies transmission of viral pathogens. Nat. Med. 10:S77-S81.