Concurrent administration of aqueous Azadirachta indica (Neem) leaf extract with DOCA-salt prevents the development of hypertension and accompanying electrocardiogram changes in the rat

Phytotherapy Research

Volumn 19, Issue 9, 2005, Pages 792-795

  Obiefuna, Idongesit ^a,b   Young, Ronald ^a  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Azadirachta indica; Blood pressure; Concurrent; Conscious rats; DOCA salt; Electrocardiogram (ECG)

Indexed keywords

AZADIRACHTA INDICA EXTRACT; DEOXYCORTICOSTERONE ACETATE; DRINKING WATER; POTASSIUM CHLORIDE; SODIUM CHLORIDE; SOYBEAN OIL;

ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; AZADIRACHTA INDICA; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; ELECTROCARDIOGRAM; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PLANT LEAF; PR INTERVAL; QRS COMPLEX; RAT; RR INTERVAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; AZADIRACHTA; BLOOD PRESSURE; DESOXYCORTICOSTERONE; ELECTROCARDIOGRAPHY; HYPERTENSION; INJECTIONS, SUBCUTANEOUS; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; SODIUM CHLORIDE, DIETARY;

ANIMALIA; AZADIRACHTA INDICA; GLYCINE MAX; RATTUS NORVEGICUS;

EID: 27644503443     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1739     Document Type: Article

References (11)

1. Berthon N, Laurant P, Havoz D, Fellman D, Brunner HR, Berthelot A. 2002 Magnesium supplementation and deoxycorticosterone acetate-salt hypertension: effect on arterial mechanical properties and on activity of endothelin-1. Can J Physiol Pharmacol 80: 553-561.
2. Bianciotti LG, de Bold AJ. 2002. Natriuretic peptide gene expression in DOCA-salt hypertension after blockade of type B endothelin receptor. Am J Physiol 3: H1127-H1134.
3. Chattopadhyay RR, Sarkar SK, Ganguly S, Banerjee RN. 1992. Active effects of Azadirachta indica leaves on some biochemical constituents of blood in rats. Sci Cult 58: 39-40.
4. Gaitonde BB, Sheth UK. 1958. Pharmacological studies of sodium nimbinate. Indian J Med Sci 12: 141.
5. Hicks PE. 1979. The effects of long term oral treatment with indapamide on the development of DOCA-salt hypertension in rats: vascular reactivity studies. Clin Exp Hypertens 1: 713-731.
6. Jaiswal AK, Bhattacharya SK, Acharya SB. 1994. Anxiolytic activity of Azadirachta indica leaf extract in rats. Indian J Exp Biol 1: 489-491.
7. Koley KM, Lal L. 1994 Pharmacological effects of Azadirachta indica (Neem) leaf extract on the ECG and blood pressure of rat. Indian J Physiol Pharmacol 38: 223-235.
8. Matsumura Y, Okui T, Ono H, Kiso Y, Tanaka T. 1995. Antihypertensive effects of Sesamin. I. Protection against deoxycorticsterone acetate-salt-induced hypertension and cardiovascular hypertrophy. Biol Pharm Bull 18: 1016-1019.
9. Obiefuna PCM, Ebeigbe AB, Sofola OA, Alaomaka CP. 1991. Altered smooth muscle responses in salt-loaded Sprague-Dawley rats. Clin Exp Pharmacol. Physiol 18: 813-818.
10. Parshad O, Gardener M, The TL, Williams LAD, Fletcher CK. 1997. Antifertility effects of aqueous and steroidal extracts of neem leaf (Azadirachta indica) in male Wistar rats. Phytother Res 11: 68-70.
11. Thompson EB, Anderson CC. 1978. Cardiovascular effects of Azadirachta indica extract. J Pharm Sci 67: 1476-1478.