Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage

Molecular Biology of the Cell

Volumn 16, Issue 11, 2005, Pages 5227-5235

  Nakada, Daisuke ^a   Hirano, Yukinori ^a   Tanaka, Yuya ^a   Sugimoto, Katsunori ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; PROTEIN DDC2; PROTEIN KINASE MEC1; REPLICATION PROTEIN A; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; RFA1 GENE; RFA2 GENE; TWO HYBRID SYSTEM; YEAST;

ANIMALS; CELL CYCLE PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; MUTATION; PHOSPHOPROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

ATAXIA TELANGIECTASIA; SACCHAROMYCETALES;

EID: 27644482826     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-05-0405     Document Type: Article

References (48)

1. Abraham, R. T. (2001). Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196.
2. Binz, S. K., Lao, Y., Lowry, D. F., and Wold, M. S. (2003). The phosphorylation domain of the 32-kDa subunit of replication protein A (RPA) modulates RPA-DNA interactions. Evidence for an intersubunit interaction. J. Biol. Chem. 278, 35584-35591.
3. Boeke, J. D., Trueheart, J., Natsoulis, G., and Fink, G. R. (1987). 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 254, 164-175.
4. Bomgarden, R. D., Yean, D., Yee, M. C., and Cimprich, K. A. (2004). A novel protein activity mediates DNA binding of an ATR-ATRIP complex. J. Biol. Chem. 279, 13346-13353.
5. Bosotti, R., Isacchi, A., and Sonnhammer, E. L. (2000). FAT: a novel domain in PIK-related kinases. Trends Biochem. Sci. 25, 225-227.
6. Brush, G. S., and Kelly, T. J. (2000). Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response. Nucleic Acids Res. 28, 3725-3732.
7. Brush, G. S., Morrow, D. M., Hieter, P., and Kelly, T. J. (1996). The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc. Natl. Acad. Sci. USA 93, 15075-15080.
8. Chan, S. W., Chang, J., Prescott, J., and Blackburn, E. H. (2001). Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr. Biol. 11, 1240-1250.
9. Clarke, L., and Carbon, J. (1980). Isolation of a yeast centromere and construction of functional small circular chromosomes. Nature 287, 504-509.
10. Cortez, D., Gunruku, S., Qin, J., and Elledge, S. J. (2001). ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713-1716.
11. Cross, F. R. (1997). Marker swap plasmids: convenient tools for budding yeast molecular genetics. Yeast 13, 647-653.
12. Edwards, R. J., Bentley, N. J., and Carr, A. M. (1999). A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat. Cell Biol. 1, 393-398.
13. Elledge, S. J. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672.
14. Futcher, B., and Carbon, J. (1986). Toxic effects of excess cloned centromeres. Mol. Cell. Biol. 6, 2213-2222.
15. Green, C. M., Erdjument-Bromage, H., Tempst, P., and Lowndes, N. F. (2000). A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr. Biol. 10, 39-42.
16. Itakura, E., Takai, K. K., Umeda, K., Kimura, M., Ohsumi, M., Tamai, K., and Matsuura, A. (2004). Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. FEBS Lett. 577, 289-293.
17. Kim, H.-S., and Brill, S. J. (2003). MEC1-dependent phosphorylation of yeast RPA in vitro. DNA Repair 2, 1321-1335.
18. Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., and Sugimoto, K. (2001). Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 5543, 867-870.
19. Lisby, M., Barlow, J. H., Burgess, R. C., and Rothstein, R. (2004). Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118, 699-713.
20. Longhese, M. P., Foiani, M., Muzi-Falconi, M., Lucchini, G., and Plevani, P. (1998). DNA damage checkpoint in budding yeast. EMBO J. 17, 5525-5528.
21. Mallory, J. C., Bashkirov, V. I., Trujillo, K. M., Solinger, J. A., Dominska, M., Sung, P., Heyer, W. D., and Petes, T. D. (2003). Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. DNA Repair 2, 1041-1064.
22. Melo, J. A., Cohen, J., and Toczyski, D. P. (2001). Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 21, 2809-2821.
23. Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., and Mieter, P. (1995). TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC2. Cell 82, 831-840.
24. Naiki, T., Kondo, T., Nakada, D., Matsumoto, K., and Sugimoto, K. (2001). Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway. Mol. Cell. Biol. 21, 5838-5845.
25. Naiki, T., Wakayama, T., Nakada, D., Matsumoto, K., and Sugimoto, K. (2004). Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism. Mol. Cell. Biol. 24, 3277-3285.
26. Nakada, D., Hirano, Y., and Sugimoto, K. (2004). Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol. Cell. Biol. 24, 10016-10025.
27. Nakada, D., Matsumoto, K., and Sugimoto, K. (2003a). ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev. 17, 1957-1962.
28. Nakada, D., Shimomura, T., Matsumoto, K., and Sugimoto, K. (2003b). The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res. 31, 1715-1724.
29. Oakley, G. G., Patrick, S. M., Yao, J., Carty, M. P., Turchi, J. J., and Dixon, K. (2003). RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry 42, 3255-3264.
30. Paciotti, V., Clerici, M., Lucchini, G., and Longhese, M. P. (2000). The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev. 14, 2046-2059.
31. Peterson, R. T., Beal, P. A., Comb, M. J., and Schreiber, S. L. (2000). FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J. Biol. Chem. 275, 7416-7423.
32. Reid, R. J., Lisby, M., and Rothstein, R. (2002). Cloning-free genome alterations in Saccharomyces cerevisiae using adaptamer-mediated PCR. Methods Enzymol. 350, 258-277.
33. Ritchie, K. B., Mollory, J. C., and Petes, T. D. (1999). Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 6065-6075.
34. Rivera-Calzada, A., Maman, J. P., Spagnolo, L., Pearl, L. H., and Llorca, O. (2005). Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Structure 13, 243-255.
35. Rouse, J., and Jackson, S. P. (2000). LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J. 19, 5793-5800.
36. Rouse, J., and Jackson, S. P. (2002). Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol. Cell 9, 857-869.
37. Sanchez, Y., Bachant, J., Wang, H., Hu, F., Liu, D., Tetzlaff, M., and Elledge, S. J. (1999). Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science 286, 1166-1171.
38. Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., and Elledge, S. J. (1996). Regulation of RAD53 by the ATM-like kinase MEC2 and TEL1 in yeast cell cycle checkpoint pathways. Science 271, 357-360.
39. Takata, H., Kanoh, Y., Gunge, N., Shirahige, K., and Matsuura, A. (2004). Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol. Cell 14, 515-522.
40. Toczyski, D. P., Galgoczy, D. J., and Hartwell, L. H. (1997). CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell 90, 1097-1106.
41. Unsal-Kacmaz, K., and Sancar, A. (2004). Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol. Cell. Biol. 24, 1292-1300.
42. Usui, T., Ogawa, H., and Petrini, J. H. (2001). A DNA damage response pathway controlled by Tell and the Mre11 complex. Mol. Cell 7, 1255-1266.
43. Wakayama, T., Kondo, T., Ando, S., Matsumoto, K., and Sugimoto, K. (2001). Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol. Cell. Biol. 21, 755-764.
44. Wold, M. S. (1997). Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. 66, 61-92.
45. Wolkow, T. D., and Enoch, T. (2003). Fission yeast Rad26 responds to DNA damage independently of Rad3. BMC Genet. 4, 6.
46. Zhao, X., Muller, E.G.D., and Rothstein, R. (1998). A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pool. Mol. Cell 2, 329-340.
47. Zhou, B.-B.S., and Elledge, S. J. (2000). The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439.
48. Zou, L., and Elledge, S. J. (2003). Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548.