Effects of Miglyol 812 on rats after 4 weeks of gavage as compared with methylcellulose/Tween 80

Drug and Chemical Toxicology

Volumn 28, Issue 4, 2005, Pages 423-432

  Sellers, Rani S ^a,d   Antman, M ^b   Phillips, J ^c   Khan, K N ^c   Furst, S M ^c  

^a Non Clinical Safety   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^c PFIZER INC   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

Drug delivery; Excipients; Methylcellulose tween; Miglyol; Rat

Indexed keywords

2 METHOXYETHANOL; EXCIPIENT; GLOBULIN; MIGLYOL; POLYSORBATE 80; TRIACYLGLYCEROL; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG SOLUBILITY; FEEDING; FEMALE; GASTROINTESTINAL TOXICITY; HISTIOCYTOSIS; HISTOPATHOLOGY; INFLAMMATION; LUNG TOXICITY; MALE; NONHUMAN; ORGAN WEIGHT; PARAMETER; RAT; STATISTICAL SIGNIFICANCE; THYMUS; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

ANIMALS; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; EATING; EXCIPIENTS; FEMALE; HISTOCYTOCHEMISTRY; MALE; METHYLCELLULOSE; ORGAN SIZE; POLYSORBATES; RATS; RATS, WISTAR; TRIGLYCERIDES; URINALYSIS;

ANIMALIA; RODENTIA;

EID: 27644473439     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540500262839     Document Type: Article

References (15)

1. Baba, N., Bracco, E. E., Hashim, S. A. (1982). Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diet containing medium chain triglyceride. Am. J. Clin. Nutr. 35(4):678-682.
2. de Smidt, P. C., Campanero, M. A., Troconiz, I. F. (2004). Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility. Int. J. Pharm. 270:109-118.
3. Furuse, M., Choi, Y.-H., Mabayo, R. T., Okumura, J.-I. (1992). Feeding behavior in rats fed diets containing medium chain triglyceride. Physiol. Behav. 52:815-817.
4. Geliebter, A., Torbay, N., Bracco, E. F., Hashim, S. A., Van Itallie, T. B. (1983). Overfeeding with medium-chain triglyceride diet results in diminished deposition of fat. Am. J. Clin. Nutr. 37(1):1-4.
5. Hill, J. O., Peters, J. C., Swift, L. L., Yang, D., Sharp, T., Abumrad, N., Greene, H. L. (1990). Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. J. Lipid Res. 31(3):407-416.
6. Hopman, W. P., Jansen, J. B., Rosenbusch, G., Lamers, C. B. (1984). Effect of equimolar amounts of long-chain triglycerides and medium-chain triglycerides on plasma cholecytokinin and gallbladder contraction. Am. J. Clin. Nutr. 39(3):356-359.
7. Ingle, D. L., Driedger, A., Traul, K. A., Nakahasi, K. K. (1999). Dietary energy value of medium-chain triglycerides. J. Food Sci. 64(6):960-963.
8. Irie, T., Uekama, K. (1997). Pharmaceutical applications of cyclo dextrins. III. Toxicological issues and safety evaluation. J. Pharm. Sci. 86(2):147-162.
9. Kawakami, K., Yoshikawa, T., Moroto, Y., Kanaoka, E., Takahashi, K., Nishihara, Y., Masuda, K. (2002). Microemulsion formulation for enhanced absorption of poorly solubilized drugs I. Prescription design. J. Control. Release 81(1-2):65-74.
10. Kohsaku, K., Yoshikawa, T., Hayashi, T., Nishihara, Y., Masuda, K. (2002). Microemulsion formulation for enhanced absorption of poorly soluble drugs II. In vivo study. J. Control. Release 81:75-82.
11. Rajewski, R. A., Stella, V. J. (1996). Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery. J. Pharm. Sci. 85(11):1142-1169.
12. Shinohara, H., Goda, T., Takase, S., Sugawa-Katayama, Y. (1993). Feeding medium-chain triglycerides to rats decreases degradation of sucrase-isomaltase complex in the jejunum. J. Nutr. 123(6):1161-1167.
13. Traul, K. A., Driedger, A., Ingle, D. L., Nakhasi, D. (2000). Review of the toxicologic properties of medium-chain triglycerides. Food Chem. Toxicol. 38:79-98.
14. Verkijk, M., Vecht, J., Gielkens, H. A., Lamers, C. B., Masclee, A. A. (1997). Effects of medium-chain and long-chain triglycerides on antroduodenal motility and small bowel transit time in man. Dig. Dis. Sci. 42(9):133-139.
15. Webb, D. R., Wood, F. E., Bertram, T. A., Fortier, N. E. (1993). A 91-day feeding study in rats with caprenin. Food Chem. Toxicol. 31(12):935-946.