Endothelial biomedicine: Its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap

Endothelium: Journal of Endothelial Cell Research

Volumn 12, Issue 3, 2005, Pages 139-151

  Hwa, Charlotte ^a   Sebastian, Anthony ^b   Aird, William C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelial cells; Endothelium

Indexed keywords

ADAPTATION; ANGIOGENESIS; ARTICLE; BIOMEDICINE; BLOOD VESSEL; CLINICAL PRACTICE; CYTOLOGY; ENDOTHELIUM; ENDOTHELIUM CELL; EPITHELIUM; MEDLINE; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; BIOMEDICAL RESEARCH; ENDOTHELIAL CELLS; ENDOTHELIUM; FINANCING, GOVERNMENT; HUMANS; MEDICINE; NATIONAL INSTITUTES OF HEALTH (U.S.); PERIODICALS; PUBMED; RESEARCH DESIGN; UNITED STATES;

EID: 27544504322     PISSN: 10623329     EISSN: 10292373     Source Type: Journal    
DOI: 10.1080/10623320500192016     Document Type: Article

References (83)

1. Aird W.C. (2001) Vascular bed-specific hemostasis: Role of endothelium in sepsis pathogenesis. Critical Care Medicine, 29, S28-S35.
2. Aird W.C. (2003a) Endothelial cell heterogeneity. Critical Care Medicine, 31, S221-S230.
3. Aird W.C. (2005) Spatial and temporal dynamics of endothelium. J Thromb Haemost., 3, 1392-1406.
4. Aird W.C. (2003b) The role of the endothelium in severe sepsis and the multiple organ dysfunction syndrome. Blood, 101, 3765-3777.
5. Ameshima S., Golpon H., Cool C.D., Chan D., Vandivier R.W., Gardai S.J., Wick M., Nemenoff R.A., Geraci M.W., and Voelkel N.F. (2003) Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circulation Research, 92, 1162-1169.
6. Apras S., Ertenli I., Ozbalkan Z., Kiraz S., Ozturk M.A., Haznedaroglu I.C., Cobankara V., Pay S., and Calguneri M. (2003) Effects of oral cyclophosphamide and prednisolone therapy on the endothelial functions and clinical findings in patients with early diffuse systemic sclerosis. Arthritis and Rheumatism, 48, 2256-2261.
7. Bender D.A., and Bender A.E. (1999) Bender's Dictionary of Nutrition and Food Technology, 7th ed. CRC Press, Boca Raton, FL; Woodhead Pub., Cambridge, England.
8. Bonetti P.O., Lerman L.O., and Lerman A. (2003) Endothelial dysfunction: A marker of atherosclerotic risk. Arteriosclerosis, Thrombosis, and Vascular Biology, 23, 168-175.
9. Breiner K.M., Schaller H., and Knolle P.A. (2001) Endothelial cell-mediated uptake of a hepatitis B virus: A new concept of liver targeting of hepatotropic microorganisms. Hepatology, 34, 803-808.
10. Brodsky S.V., Yamamoto T., Tada T., Kim B., Chen J., Kajiya F., and Goligorsky M.S. (2002) Endothelial dysfunction in ischemic acute renal failure: Rescue by transplanted endothelial cells. American Journal of Physiology Renal Physiology, 282, F1140-F1149.
11. Brown R.C., and Davis T.P. (2002) Calcium modulation of adherens and tight junction function: A potential mechanism for blood-brain barrier disruption after stroke. Stroke, 33, 1706-1711.
12. Butthep P., Rummavas S., Wisedpanichkij R., Jindadamrongwech S., Fucharoen S., and Bunyaratvej A. (2002) Increased circulating activated endothelial cells, vascular endothelial growth factor, and tumor necrosis factor in thalassemia. American Journal of Hematology, 70, 100-106.
13. Cacoub P., Ghillani P., Revelen R., Thibault V., Calvez V., Charlotte F., Musset L., Youinou P., and Piette J.C. (1999) Anti-endothelial cell auto-antibodies in hepatitis C virus mixed cryoglobulinemia. Journal of Hepatology, 31, 598-603.
14. Cella G., Sbarai A., Mazzaro G., Vanzo B., Romano S., Hoppensteadt T., and Fareed J. (2001) Plasma markers of endothelial dysfunction in chronic obstructive pulmonary disease. Clinical Applications in Thrombosis and Hemostasis, 7, 205-208.
15. Cerinic M.M., Valentine G., Sorano G.G., D'Angelo S., Cuomo G., Fenu L., Generini S., Cinotti S., Morfini M., Pignone A., Guiducci S., Del Rosso A., Kalfin R., Das D., and Marongiu F. (2003) Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis. Seminars in Arthritis and Rheumatism 32, 285-295.
16. Chan N.N., Chan W.B., and Chan J.C. (2003) Reduction of total homocysteine levels by oral folic acid fails to improve endothelial function in children with chronic renal failure. Circulation, 107, e6-e7; author reply e6-e7.
17. Chen H.M., Sunamura M., Shibuya K., Yamauchi J.I., Sakai Y., Fukuyama S., Mikami Y., Takeda K., and Matsuno S. (2001) Early microcirculatory derangement in mild and severe pancreatitis models in mice. Surgery Today, 31, 634-642.
18. Chenevard R., Hurlimann D., Bechir M., Enseleit F., Spieker L., Hermann M., Riesen W., Gay S., Gay R.E., Neidhart M., Michel B., Luscher T.F., Noll G., and Ruschitzka F. (2003) Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation, 107, 405-409.
19. Cheng T., Liu D., Griffin J.H., Fernandez J.A., Castellino F., Rosen E.D., Fukudome K., and Zlokovic B.V. (2003) Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nature Medicine, 9, 338-342.
20. Cherian P., Hankey G.J., Eikelboom J.W., Thom J., Baker R.I., McQuillan A., Staton J., and Yi Q. (2003) Endothelial and platelet activation in acute ischemic stroke and its etiological subtypes. Stroke, 34, 2132-2137.
21. Cheung Y.F., Chan G.C., and Ha S.Y. (2002) Arterial stiffness and endothelial function in patients with beta-thalassemia major. Circulation, 106, 2561-2566.
22. Churg A., Wang R.D., Tai H., Wang X., Xie C., Dai J., Shapiro S.D., and Wright J.L. (2003) Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. American Journal of Respiratory and Critical Care Medicine, 167, 1083-1089.
23. Cines D.B., Pollack E.S., Buck C.A., et al. (1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood, 91, 3527-3561.
24. Cottone S., Mule G., Amato F., Riccobene R., Vadala A., Lorito M.C., Raspanti F., and Cerasola G. (2002) Amplified biochemical activation of endothelial function in hypertension associated with moderate to severe renal failure. Journal of Nephrology, 15, 643-648.
25. Danese S., de la Motte C., Sturm A., Vogel J.D., West G.A., Strong S.A., Katz J.A., and Fiocchi C. (2003) Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology, 124, 1249-1264.
26. Dixon L.J., Morgan D.R., Hughes S.M., McGrath L.T., El-Sherbeeny N.A., Plumb R.D., Devine A., Leahey W., Johnston G.D., and McVeigh G.E. (2003) Functional consequences of endothelial nitric oxide synthase uncoupling in congestive cardiac failure. Circulation, 107, 1725-1728.
27. Dong J.F., Moake J.L., Bernardo A., Fujikawa K., Ball C., Nolasco L., Lopez J.A., and Cruz M.A. (2003) ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. Journal of Biological Chemistry, 278, 29633-29639.
28. Dry S.M., Bechard K.M., Milford E.L., Churchill W.H., and Benjamin R.J. (1999) The pathology of transfusion-related acute lung injury. American Journal of Clinical Pathology, 112, 216-221.
29. Ferrari R., Bachetti T., Agnoletti L., Comini L., and Curello S. (1998) Endothelial function and dysfunction in heart failure. European Heart Journal, 19 (Suppl G), G41-G47.
30. Ferrell W.R., Lockhart J.C., Kelso E.B., Dunning L., Plevin R., Meek S.E., Smith A.J., Hunter G.D., McLean J.S., McGarry F., Ramage R., Jiang L., Kanke T., and Kawagoe J. (2003) Essential role for proteinase-activated receptor-2 in arthritis. Journal of Clinical Investigation, 111, 35-41.
31. Gaenzer H., Marschang P., Sturm W., Neumayr G., Vogel W., Patsch J., and Weiss G. (2002) Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. Journal of the American College of Cardiology, 40, 2189-2194.
32. Greenwood J., Walters C.E., Pryce G., Kanuga N., Beraud E., Baker D., and Adamson P. (2003) Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. FASEB Journal, 17, 905-907.
33. Han B., Luo G., Shi Z.Z., Barrios R., Atwood D., Liu W., Habib G.M., Sifers R.N., Corry D.B., and Lieberman M.W. (2002) Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. American Journal of Pathology, 161, 481-490.
34. Hebbel R.P., and Vercellotti G.M. (1997) The endothelial biology of sickle cell disease. Journal of Laboratory and Clinical Medicine, 129, 288-293.
35. Hotchkiss R.S., Tinsley K.W., Swanson P.E., and Karl I.E. (2002) Endothelial cell apoptosis in sepsis. Critical Care Medicine, 30, S225-S228.
36. Jacobson S.H., Egberg N., Hylander B., and Lundahl J. (2002) Correlation between soluble markers of endothelial dysfunction in patients with renal failure. American Journal of Nephrology, 22, 42-47.
37. Kauma S., Takacs P., Scordalakes C., Walsh S., Green K., and Peng T. (2002) Increased endothelial monocyte chemoattractant protein-1 and interleukin-8 in preeclampsia. Obstetrics and Gynecology, 100, 706-714.
38. Kim K.S. (2002) Strategy of Escherichia coli for crossing the blood-brain barrier. Journal of Infectious Diseases, 186 (Suppl 2), S220-S224.
39. Klimiuk P.A., Sierakowski S., Latosiewicz R., Cylwik J.P., Cylwik B., Skowronski J., and Chwiecko J. (2002) Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis. Annals of the Rhematic Diseases, 61, 804-809.
40. Kuruganti P.A., Hinojoza J.R., Eaton M.J., Ehmann U.K., and Sobel R.A. (2002) Interferonbeta counteracts inflammatory mediator-induced effects on brain endothelial cell tight junction molecules-implications for multiple sclerosis. Journal of Neuropathology and Experimental Neurology, 61, 710-724.
41. Leask R.L., Jain N., and Butany J. (2003) Endothelium and valvular diseases of the heart. Microscopy Research and Technique, 60, 129-137.
42. Louis C., and Ballin S. (1995) Increased NIH funding no longer sacrosanct. Circulation, 92, 278.
43. Luk C.S., Gray-Statchuk L.A., Cepinkas G., and Chin-Yee I.H. (2003) WBC reduction reduces storage-associated RBC adhesion to human vascular endothelial cells under conditions of continuous flow in vitro. Transfusion, 43, 151-156.
44. Ma L., Elliott S.N., Cirino G., Buret A., Ignarro L.J., and Wallace J.L. (2001) Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release. Proceedings of the National Academy of Sciences of the United States of America, 98, 6470-6475.
45. Ma L., and Wallace J.L. (2000) Endothelial nitric oxide synthase modulates gastric ulcer healing in rats. American Journal of Physiology Gastrointestinal and Liver Physiology, 279, G341-6346.
46. Marie I., and Beny J.L. (2002) Endothelial dysfunction in murine model of systemic sclerosis: Tight-skin mice 1. Journal of Investigative Dermatology, 119, 1379-1387.
47. Masamune A., Shimosegawa T., Fujita M., Satoh A., Koizumi M., and Toyota T. (2000) Ascites of severe acute pancreatitis in rats transcriptionally up-regulates expression of interleukin-6 and -8 in vascular endothelium and mononuclear leukocytes. Digestive Diseases and Sciences, 45, 429-437.
48. Maynard S.E., Min J.Y., Merchan J., Lim K.H., Li J., Mondal S., Libermann T.A., Morgan J.P., Sellke E.W., Stillman I.E., Epstein F.H., Sukhatme V.P., and Karumanchi S.A. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. Journal of Clinical Investigation, 111, 649-658.
49. McNamara D.M., Holubkov R., Postava L., Ramani R., Janosko K., Mathier M., MacGowan G.A., Murali S., Feldman A.M., and London B. (2003) Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure. Circulation, 107, 1598-1602.
50. Meek W.O. (1910) Phagocytosis of erythrocytes by endothelial cells: Some points in connexion with it, and a method for its demonstration. Lancet, 176, 1266-1269.
51. Mitra D., Jaffe E.A., Weksler B., Hajjar K.A., Soderland C., and Laurence J. (1997) Thrombotic thrombocytopenic purpura and sporadic hemolyticuremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells. Blood, 89, 1224-1234.
52. Mouta Carreiraz C., Nasser S.M., di Tomaso E., Padera T.P., Boucher Y., Tomarev S.I., and Jain R.K. (2001) LYVE-1 is not restricted to the lymph vessels: Expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Research, 61, 8079-8084.
53. Muller A.M., Hermanns M.I., Cronen C., and Kirkpatrick C.J. (2002) Comparative study of adhesion molecule expression in cultured human macro- and microvascular endothelial cells. Experimental Molecular Pathology, 73, 171-180.
54. Musolino C., Alonci A., Bellomo G., Tringali O., Spatari G., Quartarone C., Rizzo V., Calabro L., Bagnato G., and Frisina N. (2000) Myeloproliferative disease: Markers of endothelial and platelet status in patients with essential thrombocythemia and polycythemia vera. Hematology, 4, 397-402.
55. Nagaya N., Kangawa K., Kanda M., Uematsu M., Horio T., Fukuyama N., Hino J., Harada-Shiba M., Okumura H., Tabata Y., Mochizuki N., Chiba Y., Nishioka K., Miyatake K., Asahara T., Hara H., and Mori H. (2003) Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation, 108, 889-895.
56. Neunteufl T., Heher S., Stefenelli T., Pabinger I., and Gisslinger H. (2001) Endothelial dysfunction in patients with polycythaemia vera. British Journal of Haematology, 115, 354-359.
57. Nohe B., Kiefer R.T., Ploppa A., Haeberle H.A., Schroeder T.H., and Dieterich H.J. (2003) The effects of fresh frozen plasma on neutrophil-endothelial interactions. Anesthesia and Analgesia, 97, 216-221, table of contents.
58. Pablos J.L., Santiago B., Galindo M., Torres C., Brehmer M.T., Blanco F.J., and Garcia-Lazaro F.J. (2003) Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritis. Journal of Immunology, 170, 2147-2152.
59. Paris F., Fuks Z., Kang A., Capodieci P., Juan G., Ehleiter D., Haimovitz-Friedman A., Cordon-Cardo C., and Kolesnick R. (2001) Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science, 293, 293-297.
60. Peters C.J., and Zaki S.R. (2002) Role of the endothelium in viral hemorrhagic fevers. Critical Care Medicine, 30, S268-S273.
61. Poggianti E., Venneri L., Chubuchny V., Jambrik Z., Baroncini L.A., and Picano E. (2003) Aortic valve sclerosis is associated with systemic endothelial dysfunction. Journal of American College of Cardiology, 41, 136-141.
62. Quyyumi A.A. (2003) Prognostic value of endothelial function. American Journal of Cardiologg, 91, 19H-24H.
63. Reinhart K., Bayer O., Brunkhorst F., and Meisner M. (2002) Markers of endothelial damage in organ dysfunction and sepsis. Critical Care Medicine, 30, S302-S312.
64. Rijcken E., Krieglstein C.F., Anthoni C., Laukoetter M.G., Mennigen R., Spiegel H.U., Senninger N., Bennett C.F., and Schuermann G. (2002) ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. Gut, 51, 529-535.
65. Rosenberg R.D., and Aird W.C. (1999) Vascular-bed-specific hemostasis and hypercoagulable states. New England Journal of Medicine, 340, 1555-1564.
66. Ruoslahti E. (2002) Specialization of tumour vasculature. Nature Reviews in Cancer, 2, 83-90.
67. Saunthararajah Y., Hillery C.A., Lavelle D., Molokie R., Dorn L., Bressler L., Gavazova S., Chen Y.H., Hoffman R., and DeSimone J. (2003) Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Blood, 102, 3865-38.
68. Solovey A.A., Solovey A.N., Harkness J., and Hebbel R.P. (2001) Modulation of endothelial cell activation in sickle cell disease: A pilot study. Blood, 97, 1937-1941.
69. St Croix B., Rago C., Velculescu V., Traverso G., Romans K.E., Montgomery E., Lal A., Riggins G.J., Lengauer C., Vogelstein B., and Kinzler K.W. (2000) Genes expressed in human tumor endothelium. Science, 289, 1197-1202.
70. Stockard C.R. (1915) An Experimental Analysis of the Origin of Blood and Vascular Endothelium: I. The Origin of Blood and Vascular Endothelium in Embryos without a Circulation of the Blood and in the Normal Embryo. II. A Study of Wandering Mesenchymal Cells on the Living Yolksac and their Developmental Products: Chromatophores, Vascular Endothelium and Blood Cells. Philadelphia. American Journal of Anatomy, Vol. 18, Nos. 2 and 3, September and November 1915.
71. Stone P.H., Coskun A.U., Kinlay S., Clark M.E., Sonka M., Wahle A., Ilegbusi O.J., Yeghiazarians Y., Popma J.J., Orav J., Kuntz R.E., and Feldman C.L. (2003) Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: In vivo 6-month follow-up study. Circulation, 108, 438-444.
72. Sutton T.A., Fisher C.J., and Molitoris B.A. (2002) Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney International, 62, 1539-1549.
73. Sutton T.A., Mang H.E., Campos S.B., Sandoval R.M., Yoder M.C., and Molitoris B.A. (2003) Injury of the renal microvascular endothelium alters barrier function after ischemia. American Journal of Physiology Renal Physiology, 285, F191-F198.
74. Takatsuka H., Wakae T., Mori A., Okada M., Okamoto T., and Kakishita E. (2002) Effects of total body irradiation on the vascular endothelium. Clinical Transplantation, 16, 374-377.
75. Targonski P.V., Bonetti P.O., Pumper G.M., Higano S.T., Holmes D.R., Jr., and Lerman A. (2003) Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation, 107, 2805-2809.
76. Taylor A.A. (2001) Pathophysiology of hypertension and endothelial dysfunction in patients with diabetes mellitus. Endocrinology and Metabolism Clinics of North America, 30, 983-997.
77. Turhan A., Weiss L.A., Mohandas N., Coller B.S., and Frenette P.S. (2002) Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm. Proceedings of the National Academy of Sciences of the United States of America, 99, 3047-3051.
78. Ulfman L.H., Joosten D.P., van Aalst C.W., Lammers J.W., van de Graaf E.A., Koenderman L., and Zwaginga J.J. (2003) Platelets promote eosinophil adhesion of patients with asthma to endothelium under flow conditions. American Journal of Respiratory, Cellular, and Molecular Biology, 28, 512-519.
79. van den Berg B.M., Vink H., and Spaan J.A. (2003) The endothelial glycocalyx protects against myocardial edema. Circulation Research, 92, 592-594.
80. Wheatcroft S.B., Williams I.L., Shah A.M., and Kearney M.T. (2003) Pathophysiological implications of insulin resistance on vascular endothelial function. Diabetic Medicine, 20, 255-268.
81. Wyman T.H., Bjornsen A.J., Elzi D.J., Smith C.W., England K.M., Kelher M., and Silliman C.C. (2002) A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: Requirements for adherence and chemokine release. American Journal of Physiology Cellular Physiology, 283, C1592-C1603.
82. Yeager M.E., Golpon H.A., Voelkel N.F., and Tuder R.M. (2002) Microsatellite mutational analysis of endothelial cells within plexiform lesions from patients with familial, pediatric, and sporadic pulmonary hypertension. Chests, 121, 61S.
83. Yokomori H., Oda M., Ogi M., Sakai K., and Ishii H. (2002) Enhanced expression of endothelial nitric oxide synthase and caveolin-1 in human cirrhosis. Liver, 22, 150-158.