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Volumn 23, Issue 8, 2005, Pages 485-491

Beta-lactam-induced neutropenia. An old forgotten companion;Neutropenia secundaria a betalactámicos. Una vieja compañera olvidada

Author keywords

Adverse drug reaction; Agranulocytosis; Antibiotic; Beta lactam; Neutropenia

Indexed keywords

AMPICILLIN; AZLOCILLIN; BETA LACTAM ANTIBIOTIC; CARBENICILLIN; CEFAPIRIN; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFUROXIME; CLOXACILLIN; IMIPENEM; METICILLIN; MEZLOCILLIN; NAFCILLIN; PENICILLIN G; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SULTAMICILLIN; TIMENTIN;

EID: 27544473335     PISSN: 0213005X     EISSN: None     Source Type: Journal    
DOI: 10.1157/13078841     Document Type: Review
Times cited : (8)

References (69)
  • 1
    • 0000378637 scopus 로고
    • On the antibacterial action of cultures of penicillium with special reference to their use in the isolation of B. influenzae
    • Fleming A. On the antibacterial action of cultures of penicillium with special reference to their use in the isolation of B. influenzae. Br J Exp Pathol. 1929;10:226.
    • (1929) Br J Exp Pathol , vol.10 , pp. 226
    • Fleming, A.1
  • 2
    • 0022743968 scopus 로고
    • Problems in the evaluation of adverse reactions to b-lactam antibiotics
    • Norrby SR. Problems in the evaluation of adverse reactions to b-lactam antibiotics. Rev Infect Dis. 1986;8 Suppl 3:358-67.
    • (1986) Rev Infect Dis , vol.8 , Issue.SUPPL. 3 , pp. 358-367
    • Norrby, S.R.1
  • 3
    • 0020637007 scopus 로고
    • Adverse reactions associated with the use of oral penicillins and cephalosporins
    • Alanis A, Weinstein AJ. Adverse reactions associated with the use of oral penicillins and cephalosporins. Med Clin North Am. 1983;67:113-29.
    • (1983) Med Clin North Am , vol.67 , pp. 113-129
    • Alanis, A.1    Weinstein, A.J.2
  • 4
    • 17144457536 scopus 로고
    • Cefotaxime and cephalosporins: Adverse reactions in perspective
    • Smith CR. Cefotaxime and cephalosporins: adverse reactions in perspective. Rev Infect Dis. 1982;4 Suppl:481-8.
    • (1982) Rev Infect Dis , vol.4 , Issue.SUPPL. , pp. 481-488
    • Smith, C.R.1
  • 5
    • 0002618772 scopus 로고    scopus 로고
    • Drug-induced autoimmune disease
    • Kaplan A, editor. Philadelphia: WB Saunders
    • Gorevic PD. Drug-induced autoimmune disease. En: Kaplan A, editor. Allergy. Philadelphia: WB Saunders; 1997. p. 620-43.
    • (1997) Allergy , pp. 620-643
    • Gorevic, P.D.1
  • 6
    • 0009551433 scopus 로고
    • A case of agranulocytosis occurring during the course of penicillin therapy
    • Spain DM, Clark TB. A case of agranulocytosis occurring during the course of penicillin therapy. Ann Intern Med. 1946;25:732-3.
    • (1946) Ann Intern Med , vol.25 , pp. 732-733
    • Spain, D.M.1    Clark, T.B.2
  • 7
    • 1542577755 scopus 로고    scopus 로고
    • Neutropenia in patients receiving long-term cefepime therapy for osteomyelitis
    • Wong BB, Ko GJ. Neutropenia in patients receiving long-term cefepime therapy for osteomyelitis. Am J Health Syst Pharm. 2003;60:2229-32.
    • (2003) Am J Health Syst Pharm , vol.60 , pp. 2229-2232
    • Wong, B.B.1    Ko, G.J.2
  • 8
    • 0344256603 scopus 로고    scopus 로고
    • Incidence of neutropenia during treatment of bone-related infections with piperacillin-tazobactam
    • Peralta FG, Sanchez MB, Roiz MP, Pena MA, Tejero MA, Arjona R. Incidence of neutropenia during treatment of bone-related infections with piperacillin-tazobactam. Clin Infect Dis. 2003;37:1568-72.
    • (2003) Clin Infect Dis , vol.37 , pp. 1568-1572
    • Peralta, F.G.1    Sanchez, M.B.2    Roiz, M.P.3    Pena, M.A.4    Tejero, M.A.5    Arjona, R.6
  • 10
    • 0033779070 scopus 로고    scopus 로고
    • Neutropenic enterocolitis in a trauma patient during antibiotic therapy for osteomyelitis
    • Bibbo C, Barbieru RA, Deitch EA, Brolin RE. Neutropenic enterocolitis in a trauma patient during antibiotic therapy for osteomyelitis. J Trauma. 2000;49:760-63.
    • (2000) J Trauma , vol.49 , pp. 760-763
    • Bibbo, C.1    Barbieru, R.A.2    Deitch, E.A.3    Brolin, R.E.4
  • 11
    • 0035956288 scopus 로고    scopus 로고
    • Antibiotic-induced agranulocitosis: A monocentric study of 21 cases
    • Andres E, Maloisel F. Antibiotic-induced agranulocitosis: a monocentric study of 21 cases. Arch Intern Med. 2001;161:2619.
    • (2001) Arch Intern Med , vol.161 , pp. 2619
    • Andres, E.1    Maloisel, F.2
  • 12
    • 0027476231 scopus 로고
    • β-lactam antibiotic-induced leukopenia in severe hepatic dysfunction: Risk factors and implications for dosing in patients with liver disease
    • Singh N, Yu VL, Mieles LA, Wagener MM. β-Lactam antibiotic-induced leukopenia in severe hepatic dysfunction: risk factors and implications for dosing in patients with liver disease. Am J Med. 1993;94:251-6.
    • (1993) Am J Med , vol.94 , pp. 251-256
    • Singh, N.1    Yu, V.L.2    Mieles, L.A.3    Wagener, M.M.4
  • 14
    • 0030600088 scopus 로고    scopus 로고
    • Safety of Cefepime: A new extended-spectrum parenteral cephalosporin
    • Neu HC. Safety of Cefepime: a new extended-spectrum parenteral cephalosporin. Am J Med. 1996;100 Suppl 6A:68-75.
    • (1996) Am J Med , vol.100 , Issue.SUPPL. 6A , pp. 68-75
    • Neu, H.C.1
  • 15
    • 0025217216 scopus 로고
    • A prospective study of neutropenia induced by high doses of β-lactam antibiotics
    • Olaison L, Alestig K. A prospective study of neutropenia induced by high doses of β-lactam antibiotics. J Antimicrob Chemother. 1990;25:449-53.
    • (1990) J Antimicrob Chemother , vol.25 , pp. 449-453
    • Olaison, L.1    Alestig, K.2
  • 16
    • 0033594222 scopus 로고    scopus 로고
    • Incidence of beta-lactam-induced delayed hypersensitivity and neutropenia during treatment of infective endocarditis
    • Olaison L, Belin L, Hogevik H, Alestig K. Incidence of beta-lactam-induced delayed hypersensitivity and neutropenia during treatment of infective endocarditis. Arch Intern Med. 1999;159:607-15.
    • (1999) Arch Intern Med , vol.159 , pp. 607-615
    • Olaison, L.1    Belin, L.2    Hogevik, H.3    Alestig, K.4
  • 17
    • 0032754239 scopus 로고    scopus 로고
    • Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment: A retrospective analysis in 38 children with cystic fibrosis
    • Reichardt P, Handrick W, Linke A, Schille R, Kiess W. Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment: a retrospective analysis in 38 children with cystic fibrosis. Infection. 1999;27:355-6.
    • (1999) Infection , vol.27 , pp. 355-356
    • Reichardt, P.1    Handrick, W.2    Linke, A.3    Schille, R.4    Kiess, W.5
  • 18
    • 0020420915 scopus 로고
    • Adverse effects of methicillin, nafcillin and oxacillin in pediatric patients
    • Nahata MC, DeBolt SL, Powell DA. Adverse effects of methicillin, nafcillin and oxacillin in pediatric patients. Dev Pharmacol Ther. 1982;4:117-23.
    • (1982) Dev Pharmacol Ther , vol.4 , pp. 117-123
    • Nahata, M.C.1    DeBolt, S.L.2    Powell, D.A.3
  • 19
    • 0026027567 scopus 로고
    • Adverse reactions to prolonged treatment with high doses of carbenicillin and ureidopenicillins
    • Lang R, Lishner M, Ravid M. Adverse reactions to prolonged treatment with high doses of carbenicillin and ureidopenicillins. Rev Infect Dis. 1991;13:68-72.
    • (1991) Rev Infect Dis , vol.13 , pp. 68-72
    • Lang, R.1    Lishner, M.2    Ravid, M.3
  • 20
    • 0019809991 scopus 로고
    • Reversible neutropenia associated with ampicillin therapy in pediatric patients
    • Kumar K, Kumar A. Reversible neutropenia associated with ampicillin therapy in pediatric patients. Drug Intell Clin Pharm. 1981;15:802-6.
    • (1981) Drug Intell Clin Pharm , vol.15 , pp. 802-806
    • Kumar, K.1    Kumar, A.2
  • 21
    • 0019449083 scopus 로고
    • Comparative toxicities of methicillin and nafcillin
    • Kitzing W, Nelson JD, Mohs E. Comparative toxicities of methicillin and nafcillin. Am J Dis Child. 1981;135:52-5.
    • (1981) Am J Dis Child , vol.135 , pp. 52-55
    • Kitzing, W.1    Nelson, J.D.2    Mohs, E.3
  • 23
    • 0018126083 scopus 로고
    • Adverse reactions to methicillin and nafcillin during treatment of serious Staphylococcus aureus infections
    • Kancir LM, Tuazon CU, Cardella TA, Sheagren JN. Adverse reactions to methicillin and nafcillin during treatment of serious Staphylococcus aureus infections. Arch Intern Med. 1978;138:909-11.
    • (1978) Arch Intern Med , vol.138 , pp. 909-911
    • Kancir, L.M.1    Tuazon, C.U.2    Cardella, T.A.3    Sheagren, J.N.4
  • 29
    • 0029415041 scopus 로고
    • Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis
    • Burton IE, Moussa KM, Sanders PA. Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis. Acta Haematol. 1995;94:196-8.
    • (1995) Acta Haematol , vol.94 , pp. 196-198
    • Burton, I.E.1    Moussa, K.M.2    Sanders, P.A.3
  • 35
    • 0022971332 scopus 로고
    • The safety profile of imipenem/cilastatin: Worldwide clinical experience based on 3470 patients
    • Calandra GB, Wang C, Aziz M, Brown KR. The safety profile of imipenem/cilastatin: worldwide clinical experience based on 3470 patients. J Antimicrob Chemother 1986;18 Suppl E:193-202.
    • (1986) J Antimicrob Chemother , vol.18 , Issue.SUPPL. E , pp. 193-202
    • Calandra, G.B.1    Wang, C.2    Aziz, M.3    Brown, K.R.4
  • 36
    • 0025769421 scopus 로고
    • Aztreonam-induced myelosuppression during treatment of Pseudomonas aeruginosa pneumonia
    • Dallai MM, Czachor JS. Aztreonam-induced myelosuppression during treatment of Pseudomonas aeruginosa pneumonia. DICP. 1991;25:594-7.
    • (1991) DICP , vol.25 , pp. 594-597
    • Dallai, M.M.1    Czachor, J.S.2
  • 37
    • 0030727872 scopus 로고    scopus 로고
    • Two cases of possible Cefepime-induced neutropenia
    • Dahlgren AF. Two cases of possible Cefepime-induced neutropenia. Am J Health Syst Pharm. 1997;54:2621-2.
    • (1997) Am J Health Syst Pharm , vol.54 , pp. 2621-2622
    • Dahlgren, A.F.1
  • 38
    • 0030461709 scopus 로고    scopus 로고
    • Reversible bone marrow depression by high-dose piperacillin/tazobactam
    • Ruiz-Irastorza G, Barreiro G, Aguirre C. Reversible bone marrow depression by high-dose piperacillin/tazobactam. Br J Haematol. 1996;95:611-2.
    • (1996) Br J Haematol , vol.95 , pp. 611-612
    • Ruiz-Irastorza, G.1    Barreiro, G.2    Aguirre, C.3
  • 39
    • 0029092430 scopus 로고
    • Hypersensitivity reaction during prolonged use of piperacillin/tazobactam in treatment of osteomyelitis
    • Behbahani R, Kostman JR. Hypersensitivity reaction during prolonged use of piperacillin/tazobactam in treatment of osteomyelitis. Ann Pharmacother. 1995;29:936-7.
    • (1995) Ann Pharmacother , vol.29 , pp. 936-937
    • Behbahani, R.1    Kostman, J.R.2
  • 40
    • 0028824968 scopus 로고
    • Life-threatening neutropenia secondary to piperacillin/tazobactam therapy
    • Gerber L, Wing EJ. Life-threatening neutropenia secondary to piperacillin/tazobactam therapy. Clin Infect Dis. 1995;21:1047-8.
    • (1995) Clin Infect Dis , vol.21 , pp. 1047-1048
    • Gerber, L.1    Wing, E.J.2
  • 41
    • 0021330799 scopus 로고
    • Agranulocytosis associated with semisynthetic penicillins and cephalosporines: Review of 7 cases
    • Schmid L, Heit W, Flury R. Agranulocytosis associated with semisynthetic penicillins and cephalosporines: review of 7 cases. Blut. 1984;48:11-8.
    • (1984) Blut , vol.48 , pp. 11-18
    • Schmid, L.1    Heit, W.2    Flury, R.3
  • 42
    • 0029826451 scopus 로고    scopus 로고
    • Drug-related blood dyscrasias in a Swedish reporting system, 1985-1994
    • Wiholm BE, Emanuelsson S. Drug-related blood dyscrasias in a Swedish reporting system, 1985-1994. Eur J Haematol Suppl. 1996;60:42-6.
    • (1996) Eur J Haematol Suppl , vol.60 , pp. 42-46
    • Wiholm, B.E.1    Emanuelsson, S.2
  • 43
    • 0031935228 scopus 로고    scopus 로고
    • Drug-associated agranulocytosis: 20 Years of reporting in the Netherlands (1974-1994)
    • Van der Klauw MM, Wilson JHP, Stricker BH. Drug-associated agranulocytosis: 20 years of reporting in the Netherlands (1974-1994). Am J Hematol. 1998;57:206-11.
    • (1998) Am J Hematol , vol.57 , pp. 206-211
    • Van Der Klauw, M.M.1    Wilson, J.H.P.2    Stricker, B.H.3
  • 44
    • 0018139334 scopus 로고
    • Drug-induced immunological neutropenia
    • Weitzman SA, Stossel TP. Drug-induced immunological neutropenia. Lancet. 1978;1(8073):1068-72.
    • (1978) Lancet , vol.1 , Issue.8073 , pp. 1068-1072
    • Weitzman, S.A.1    Stossel, T.P.2
  • 45
    • 0024588435 scopus 로고
    • Anti-infective drug use in relation to the risk of agranulocytosis and aplastic anemia. A report from the International Agranulocytosis and Aplastic Anemia Study
    • Anti-infective drug use in relation to the risk of agranulocytosis and aplastic anemia. A report from the International Agranulocytosis and Aplastic Anemia Study. Arch Intern Med. 1989;149:1036-40.
    • (1989) Arch Intern Med , vol.149 , pp. 1036-1040
  • 46
    • 0022376398 scopus 로고
    • Editorial. Antibiotic-induced neutropenia
    • Editorial. Antibiotic-induced neutropenia. Lancet. 1985;2:814.
    • (1985) Lancet , vol.2 , pp. 814
  • 47
    • 0021854474 scopus 로고
    • Inhibition of granulopoiesis in vivo and in vitro by β-lactam antibiotics
    • Neftel KA, Hauser SP, Müller MR. Inhibition of granulopoiesis in vivo and in vitro by β-lactam antibiotics. J Infect Dis. 1985;152:90-8.
    • (1985) J Infect Dis , vol.152 , pp. 90-98
    • Neftel, K.A.1    Hauser, S.P.2    Müller, M.R.3
  • 49
    • 0021330799 scopus 로고
    • Agranulocytosis associated with semisynthetic penicillins and cephalosporins. Report of 7 cases
    • Schmid L, Heit W, Flury R. Agranulocytosis associated with semisynthetic penicillins and cephalosporins. Report of 7 cases. Blut. 1984;48:11-8.
    • (1984) Blut , vol.48 , pp. 11-18
    • Schmid, L.1    Heit, W.2    Flury, R.3
  • 50
    • 0023608343 scopus 로고
    • Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha
    • Do UH, Neftel KA, Spadari S, Hubscher U. Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha. Nucleic Acids Res. 1987;15:10495-506.
    • (1987) Nucleic Acids Res , vol.15 , pp. 10495-10506
    • Do, U.H.1    Neftel, K.A.2    Spadari, S.3    Hubscher, U.4
  • 51
    • 0026068723 scopus 로고
    • The effect of amphotericin B, aztreonam, imipenem and cephalosporins on the bone marrow progenitor cell activity
    • Charak BS, Louie R, Malloy B, Twomey P, Mazumder A. The effect of amphotericin B, aztreonam, imipenem and cephalosporins on the bone marrow progenitor cell activity. J Antimicrob Chemother. 1991;27:95-104.
    • (1991) J Antimicrob Chemother , vol.27 , pp. 95-104
    • Charak, B.S.1    Louie, R.2    Malloy, B.3    Twomey, P.4    Mazumder, A.5
  • 52
    • 0021016381 scopus 로고
    • Neutropenia due to β-lactamine antibodies
    • Rouveix B, Lassoued K, Vittecoq D, Regnier B. Neutropenia due to β-lactamine antibodies. BMJ. 1983;287:1832-4.
    • (1983) BMJ , vol.287 , pp. 1832-1834
    • Rouveix, B.1    Lassoued, K.2    Vittecoq, D.3    Regnier, B.4
  • 53
    • 0027491440 scopus 로고
    • Immune cytopenia associated with antibiotics
    • Garraty G. Immune cytopenia associated with antibiotics. Transfus Med Rev. 1993;7:255-67.
    • (1993) Transfus Med Rev , vol.7 , pp. 255-267
    • Garraty, G.1
  • 54
    • 0020634723 scopus 로고
    • Demonstration of an immune-mediated mechanism of penicillin-induced neutropenia and thrombocytopenia
    • Murphy MF, Riordan T, Minchinton RM, Chapman JF, Amess JA, Shaw EJ, et al. Demonstration of an immune-mediated mechanism of penicillin-induced neutropenia and thrombocytopenia. Br J Haematol. 1983;55:155-60.
    • (1983) Br J Haematol , vol.55 , pp. 155-160
    • Murphy, M.F.1    Riordan, T.2    Minchinton, R.M.3    Chapman, J.F.4    Amess, J.A.5    Shaw, E.J.6
  • 55
    • 0023242554 scopus 로고
    • Severe neutropenia in prolonged treatment with orally administered Augmentin® (amoxicillin/clavulanic acid)
    • Desgrandchamps D, Schnyder C. Severe neutropenia in prolonged treatment with orally administered Augmentin® (amoxicillin/clavulanic acid). Infection 1987;15:44-5.
    • (1987) Infection , vol.15 , pp. 44-45
    • Desgrandchamps, D.1    Schnyder, C.2
  • 56
    • 0032898726 scopus 로고    scopus 로고
    • Piperacillin/tazobactam: An updated review of its use in the treatment of bacterial infections
    • Perry CM, Markham A. Piperacillin/tazobactam: an updated review of its use in the treatment of bacterial infections. Drugs. 1999;57:805-43.
    • (1999) Drugs , vol.57 , pp. 805-843
    • Perry, C.M.1    Markham, A.2
  • 57
    • 0035145047 scopus 로고    scopus 로고
    • Severe skin and soft tissue infections study group. Clinafloxacin versus piperacillin-tazobactam in treatment of patients with severe skin and soft tissue infections
    • Siami G, Christou N, Eiseman I, Tack KJ. Severe skin and soft tissue infections study group. Clinafloxacin versus piperacillin-tazobactam in treatment of patients with severe skin and soft tissue infections. Antimicrob Agents Chemother. 2001;45:525-31.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 525-531
    • Siami, G.1    Christou, N.2    Eiseman, I.3    Tack, K.J.4
  • 58
    • 0036604093 scopus 로고    scopus 로고
    • Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: Results of a prospective, randomized, double-blind multicenter study
    • Graham DR, Lucasti C, Malafaia O, Nichols RL, Holtom P, Pérez NQ, et al. Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study. Clin Infect Dis. 2002;34:1460-8.
    • (2002) Clin Infect Dis , vol.34 , pp. 1460-1468
    • Graham, D.R.1    Lucasti, C.2    Malafaia, O.3    Nichols, R.L.4    Holtom, P.5    Pérez, N.Q.6
  • 59
    • 0020472757 scopus 로고
    • The safety and tolerance of mezlocilin
    • Parry MF, Neu NH. The safety and tolerance of mezlocilin. J Antimicrob Chemother. 1982;9 Suppl A:273-80.
    • (1982) J Antimicrob Chemother , vol.9 , Issue.SUPPL. A , pp. 273-280
    • Parry, M.F.1    Neu, N.H.2
  • 62
    • 0037373395 scopus 로고    scopus 로고
    • Combination antibiotic therapy for infective endocarditis
    • Le T, Bayer AS. Combination antibiotic therapy for infective endocarditis. Clin Infect Dis. 2003;36:615-21.
    • (2003) Clin Infect Dis , vol.36 , pp. 615-621
    • Le, T.1    Bayer, A.S.2
  • 64
    • 0031036383 scopus 로고    scopus 로고
    • Suspected interstitial nephritis induced by piperacillin-tazobactam
    • Pill MW, O'Neill CV, Chapman MM, Singh AK. Suspected interstitial nephritis induced by piperacillin-tazobactam. Pharmacotherapy. 1997;17:166-9.
    • (1997) Pharmacotherapy , vol.17 , pp. 166-169
    • Pill, M.W.1    O'Neill, C.V.2    Chapman, M.M.3    Singh, A.K.4
  • 65
    • 0032980762 scopus 로고    scopus 로고
    • Nonchemotherapy drug-induced agranulocytosis: A review of 118 patients treated with colony-stimulating factors
    • Beauchesne MF, Shalansky SJ. Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors. Pharmacotherapy. 1999;19:299-305.
    • (1999) Pharmacotherapy , vol.19 , pp. 299-305
    • Beauchesne, M.F.1    Shalansky, S.J.2
  • 67
    • 0018357116 scopus 로고
    • Neutropenia after consecutive treatment courses with nafcillin and piperacillin
    • Wilson C, Greenhood G, Remington JS, Vosti KL. Neutropenia after consecutive treatment courses with nafcillin and piperacillin. Lancet. 1979;972:1150.
    • (1979) Lancet , vol.972 , pp. 1150
    • Wilson, C.1    Greenhood, G.2    Remington, J.S.3    Vosti, K.L.4
  • 68
    • 0021750586 scopus 로고
    • Leucopenia associated with beta-lactam antibiotic therapy
    • Kaaja R, Valtonen W. Leucopenia associated with beta-lactam antibiotic therapy. Acta Med Scand. 1984;216:531-4.
    • (1984) Acta Med Scand , vol.216 , pp. 531-534
    • Kaaja, R.1    Valtonen, W.2
  • 69
    • 0024547908 scopus 로고
    • Do double-beta-lactam combinations prolong neutropenia in patients undergoing chemotherapy or bone marrow transplantation for hematological disease?
    • Kibbler CC, Prentice HG, Sage RJ, Hoffbrand AV, Brenner MK, Noone P. Do double-beta-lactam combinations prolong neutropenia in patients undergoing chemotherapy or bone marrow transplantation for hematological disease? Antimicrob Agents Chemother. 1989;33:503-7.
    • (1989) Antimicrob Agents Chemother , vol.33 , pp. 503-507
    • Kibbler, C.C.1    Prentice, H.G.2    Sage, R.J.3    Hoffbrand, A.V.4    Brenner, M.K.5    Noone, P.6


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