Universal approach towards r-hirudin derivatives with high anti-thrombin activity based on chemical differentiation of primary amino groups

Macromolecular Bioscience

Volumn 2, Issue 2, 2002, Pages 82-87

  Lahann, Jörg ^a   Plüster, Wilhelm ^a   Rodon, Teresa ^a   Fabry, Marlies ^a   Klee, Doris ^a   Gattner, Hans Gregor ^a   Höcker, Hartwig ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Biomaterials; Biotinylation; MALDI; Protein derivatization; r hirudin

Indexed keywords

ALKYLATION; BIOMATERIALS; CHROMATOGRAPHIC ANALYSIS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

BIOTINYLATION; ION EXCHANGE CHROMATOGRAPHY; PROTEIN DERIVATIZATION; R HIRUDIN;

NITROGEN COMPOUNDS;

AMINO ACID DERIVATIVE; BIOMATERIAL; HIRUDIN DERIVATIVE; LYSINE; POLYMER; RECOMBINANT HIRUDIN; STREPTAVIDIN; THROMBIN INHIBITOR;

AMINO TERMINAL SEQUENCE; ANTICOAGULATION; ARTICLE; BIOTINYLATION; CHEMICAL MODIFICATION; CONJUGATION; ION EXCHANGE CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; STRUCTURE ACTIVITY RELATION;

EID: 27544468523     PISSN: 16165187     EISSN: 16165195     Source Type: Journal    
DOI: 10.1002/1616-5195(20020201)2:2<82::AID-MABI82>3.0.CO;2-4     Document Type: Article

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