Anti-DNA topoisomerase II α autoantibodies in Japanese patients with systemic sclerosis

Archives of Dermatological Research

Volumn 297, Issue 4, 2005, Pages 180-183

  Hayakawa, Ikuko ^a   Hasegawa, Minoru ^a   Takehara, Kazuhiko ^a   Sato, Shinichi ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

Anti DNA topoisomerase II antibody; Inflammation; Pulmonary fibrosis; Systemic sclerosis

Indexed keywords

AUTOANTIBODY; C REACTIVE PROTEIN; DEOXYRIBONUCLEIC ACID TOPOISOMERASE II ALPHA AUTOANTIBODY; DNA TOPOISOMERASE (ATP HYDROLYSING); IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; BLOOD SAMPLING; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FREQUENCY ANALYSIS; HUMAN; HUMAN CELL; JAPAN; LUNG FIBROSIS; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; SEROLOGY; STATISTICAL SIGNIFICANCE; SYSTEMIC SCLEROSIS;

ADULT; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; AUTOANTIBODIES; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOPRECIPITATION; INFLAMMATION; MALE; MIDDLE AGED; PULMONARY FIBROSIS; SCLERODERMA, SYSTEMIC;

EID: 27544463468     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-005-0603-7     Document Type: Article

References (15)

1. Grigolo B, Mazzetti I, Borzi RM, Hickson ID, Fabbri M, Fasano L, Meliconi R, Facchini A (1998) Mapping of topoisomerase II α epitopes recognized by autoantibodies in idiopathic pulmonary fibrosis. Clin Exp Immunol 114:339-346
2. Grigolo B, Mazzetti I, Meliconi R, Bazzi S, Scorza R, Candela M, Gabrielli A, Facchini A (2000) Anti-topoisomerase II α autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35. Clin Exp Immunol 121:539-543
3. Hayakawa I, Hasegawa M, Takehara K, Sato S (2004) Anti-DNA topoisomerase IIα autoantibodies in localized scleroderma. Arthritis Rheum 50:227-232
4. Chang YH, Hwang J, Shang HF, Tsai ST (1996) Characterization of human DNA topoisomerase II as an autoantigen recognized by patients with IDDM. Diabetes 45:408-414
5. Zuklys KL, Szer IS, Szer W (1991) Autoantibodies to DNA topoisomerase II in juvenile rheumatoid arthritis. Clin Exp Immunol 84:245-249
6. Hoffmann A, Heck MM, Bordwell BJ, Rothfield NF, Earnshaw WC (1989) Human autoantibody to topoisomerase II. Exp Cell Res 180:409-418
7. Meliconi R, Bestagno M, Sturani C, Negri C, Galavotti V, Sala C, Facchini A, Ciarrocchi G, Gasbarrini G, Astaldi Ricotti GC (1989) Autoantibodies to DNA topoisomerase II in cryptogenic fibrosing alveolitis and connective tissue disease. Clin Exp Immunol 76:184-189
8. Kuwana M, Okano Y, Kaburaki J, Tojo T, Medsger TA Jr (1994) Racial differences in the distribution of systemic sclerosis-related serum antinuclear antibodies. Arthritis Rheum 37:902-906
9. Kuwana M, Kaburaki J, Arnett FC, Howard RF, Medsger TA, Jr, Wright TM (1999) Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. Arthritis Rheum 42:465-474
10. Subcommittee for Scleroderma Criteria of the American Rhematism Association Diagnostic and Therapeuric Criteria Committee (1980) Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23:581-590
11. LeRoy EC, Krieg T, Black C, Medsger TAJ, Fleischmajer R, Rowell N, Jablonska S, Wollheim F (1988) Scleroderma (systemic sclerosis): classification, subsets, and pathogenesis. J Rheumatol 15:202-205
12. Steen VD, Powell DL, Medsger TAJ (1988) Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis Rheum 31:196-203
13. Sato S, Ihn H, Soma Y, Igarashi A, Tamaki T, Kikuchi K, Ishibashi Y, Takehara K (1993) Antihistone antibodies in patients with localized scleroderma. Arthritis Rheum 36:1137-1141
14. Silver RM (1996) Clinical problems: the lungs. Rheum Dis Clin Nor Am 22:825-840
15. LeRoy EC (1974) Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. J Clin Invest 54:880-889