Multiinjection approach for D2 receptor binding quantification in living rats using [11C]raclopride and the β-microprobe: Crossvalidation with in vitro binding data

Journal of Cerebral Blood Flow and Metabolism

Volumn 25, Issue 11, 2005, Pages 1517-1527

  Mauger, Gweltas ^a,b,d   Saba, Wadad ^c   Hantraye, Philippe ^a,c,d   Dolle, Frédéric ^c   Coulon, Christine ^c   Bramoullé, Yann ^c   Chalon, Sylvie ^e   Grégoire, Marie Claude ^a,d  

^a CNRS   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c Isotopic Imaging Biochemical and Pharmacological Unit   (France)

^d SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^e INSERM   (France)

Author keywords

microprobe; 11C raclopride; Compartmental modeling; D2 receptors; Multiinjection

Indexed keywords

CARBON 11; CIMETIDINE; CYTOCHROME P450 INHIBITOR; DOPAMINE 2 RECEPTOR; DRUG METABOLITE; RACLOPRIDE; RADIOLIGAND; CARBON; CYTOCHROME P450; DOPAMINE RECEPTOR BLOCKING AGENT; ENZYME INHIBITOR;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CATABOLISM; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; IN VITRO STUDY; KINETICS; MALE; METABOLITE; MICROANALYSIS; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY; ANIMAL; BASAL GANGLION; BRAIN LEVEL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; LEWIS RAT; METABOLISM; ORGAN CULTURE TECHNIQUE; PROTEIN BINDING;

ANIMALS; BASAL GANGLIA; BRAIN CHEMISTRY; CARBON RADIOISOTOPES; CEREBRAL CORTEX; CIMETIDINE; CYTOCHROME P-450 ENZYME SYSTEM; DOPAMINE ANTAGONISTS; ENZYME INHIBITORS; MALE; MOLECULAR PROBES; ORGAN CULTURE TECHNIQUES; PROTEIN BINDING; RACLOPRIDE; RATS; RATS, INBRED LEW; RECEPTORS, DOPAMINE D2;

EID: 27544446126     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600141     Document Type: Article

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