Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators

Toxicology

Volumn 216, Issue 1, 2005, Pages 32-40

  Krejcova Kunesova, Gabriela ^a   Bartosova, Lucie ^a   Kuca, Kamil ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Atropine; Cyclosarin; Functional observational battery; Nerve agents; Oximes; Rats; Reactivators

Indexed keywords

1 (2 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM) 2 OXAPROPANE DICHLORIDE; 1 (3 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ANTIDOTE; ATROPINE; O CYCLOHEXYLMETHYLFLUOROPHOSPHONATE; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL WARFARE; CONTROLLED STUDY; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENCY; DRUG POTENTIATION; LD 50; MALE; MONOTHERAPY; NEUROPHARMACOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL RATE; TOXICITY TESTING;

ANIMALS; ANTIDOTES; BEHAVIOR, ANIMAL; CHEMICAL WARFARE AGENTS; INJECTIONS, INTRAMUSCULAR; MALE; MOLECULAR STRUCTURE; NEUROTOXICITY SYNDROMES; ORGANOPHOSPHORUS COMPOUNDS; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 27444447557     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.07.014     Document Type: Article

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