Challenges in the study of neuronal differentiation: A view from the embryonic eye

Developmental Dynamics

Volumn 234, Issue 3, 2005, Pages 454-463

  Adler, Ruben ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell commitment; Combinatorial gene effects; Extracellular signals; Gain of function; Loss of function; Neuronal markers

Indexed keywords

CELL DIFFERENTIATION; CELL FATE; CHICK EMBRYO; COMBINATORIAL LIBRARY; DOWN REGULATION; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; IN SITU HYBRIDIZATION; MITOSIS; MULTIPOTENT STEM CELL; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PRIORITY JOURNAL; REGULATORY MECHANISM; RETINA AMACRINE CELL; RETINA GANGLION CELL; REVIEW; SIGNAL TRANSDUCTION; TECHNIQUE;

ANIMALS; CELL DIFFERENTIATION; EYE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; NEURONS; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 27444441385     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20521     Document Type: Review

References (150)

1. Abe Y, Minegishi T, Leung PC. 2004. Activin receptor signaling. Growth Factors 22:105-110.
2. Adler R. 2000. A model of retinal cell differentiation in the chick embryo. Prog Retin Eye Res 20:529-557.
3. Adler R, Belecky-Adams TL. 2002. The role of bone morphogenetic proteins in the differentiation of the ventral optic cup. Development 129:3161-3171.
4. Adler R, Lindsey JD, Elsner CL. 1984. Expression of cone-like properties by chick embryo neural retina cells in glial-free monolayer cultures. J Cell Biol 99:1173-1178.
5. Adler R, Curcio C, Hicks D, Price D, Wong F. 1999. Cell death in age-related macular degeneration. Mol Vis 5:31.
6. Altshuler D, Lo Turco JJ, Rush J, Cepko C. 1993. Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development 119:1317-1328.
7. Austin CP, Feldman DE, Ida JA Jr, Cepko CL. 1995. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development 121:3637-3650.
8. Balemans W, Van Hul W. 2002. Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev Biol 250:231-250.
9. Barnstable CJ, Blum AS, Devoto SH, Hicks D, Morabito MA, Sparrow JR, Treisman JE. 1988. Cell differentiation and pattern formation in the developing mammalian retina. Neurosci Res Suppl 8:S27-S41.
10. Becker DL, Mobbs P. 1999. Connexin alpha 1 and cell proliferation in the developing chick retina. Exp Neurol 156:326-332.
11. Belecky-Adams T, Adler R. 2001. Developmental expression patterns of bone morphogenetic proteins, receptors, and binding proteins in the chick retina. J Comp Neurol 430:562-572.
12. Belecky-Adams T, Cook B, Adler R. 1996. Correlations between terminal mitosis and differentiated fate of retinal precursor cells in vivo and in vitro: analysis with the "window-labeling" technique. Dev Biol 178:304-315.
13. Belecky-Adams T, Tomarev S, Li HS, Ploder L, McInnes RR, Sundin O, Adler R. 1997. Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells. Invest Ophthalmol Vis Sci 38:1293-1303.
14. Belecky-Adams TL, Scheurer D, Adler R. 1999. Activin family members in the developing chick retina: expression patterns, protein distribution, and in vitro effects. Dev Biol 210:107-123.
15. Boulton M, Albon J. 2004. Stem cells in the eye. Int J Biochem Cell Biol 36:643-657.
16. Bradford RL, Wang C, Zack DJ, Adler R. 2005. Roles of cell-intrinsic and microenvironmental factors in photoreceptor cell differentiation. Dev Biol (in press).
17. Brady G. 2000. Expression profiling of single mammalian cells-small is beautiful. Yeast 17:211-217.
18. Brady G, Iscove NN. 1993. Construction of cDNA libraries from single cells. Methods Enzymol 225:611-623.
19. Bruhn SL, Cepko CL. 1996. Development of the pattern of photoreceptors in the chick retina. J Neurosci 16:1430-1439.
20. Bumsted K, Jasoni C, Szel A, Hendrickson A. 1997. Spatial and temporal expression of cone opsins during monkey retinal development. J Comp Neurol 378:117-134.
21. Butte MJ. 2001. Neurotrophic factor structures reveal clues to evolution, binding, specificity, and receptor activation. Cell Mol Life Sci 58:1003-1013.
22. Campochiaro PA, Hackett SF, Vinores SA. 1996. Growth factors in the retina and retinal pigmented epithelium. Prog Retin Eye Res 15:547-567.
23. Carri NG. 2003. Multiple neurotrophic signalling: certain TGF molecules are involved in retinal development and maturation, but do they complement one another's actions? Cell Biol Int 27:1033-1036.
24. Carter BD, Lewin GR. 1997. Neurotrophins live or let die: does p75NTR decide? Neuron 18:187-190.
25. Cepko C. 1993. Lineage versus environment in the embryonic retina. Trends Neurosci 16:96-97.
26. Cepko CL. 1996. The patterning and onset of opsin expression in vertebrate retinae. Curr Opin Neurobiol 6:542-546.
27. Cepko CL. 2001. Genomics approaches to photoreceptor development and disease. Harvey Lect 97:85-110.
28. Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. 1996. Cell fate determination in the vertebrate retina. Proc Natl Acad Sci U S A 93:589-595.
29. Chiang MK, Melton DA. 2003. Single-cell transcript analysis of pancreas development. Dev Cell 4:383-393.
30. Chow RL, Altmann CR, Lang RA, Hemmati-Brivanlou A. 1999. Pax6 induces ectopic eyes in a vertebrate. Development 126:4213-4222.
31. Cook T, Desplan C. 2001. Photoreceptor subtype specification: from flies to humans. Semin Cell Dev Biol 12:509-518.
32. Davies AM. 1996. The neurotrophic hypothesis: where does it stand? Philos Trans R Soc Lond B Biol Sci 351:389-394.
33. Dulac C. 1998. Cloning of genes from single neurons. Curr Top Dev Biol 36:245-258.
34. Eberwine J, Kacharmina JE, Andrews C, Miyashiro K, McIntosh T, Becker K, Barrett T, Hinkle D, Dent G, Marciano P. 2001. mRNA expression analysis of tissue sections and single cells. J Neurosci 21:8310-8314.
35. Ezzeddine ZD, Yang X, DeChiara T, Yancopoulos G, Cepko CL. 1997. Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development 124:1055-1067.
36. Fontaine V, Kinkl N, Sahel J, Dreyfus H, Hicks D. 1998. Survival of purified rat photoreceptors in vitro is stimulated directly by fibroblast growth factor-2. J Neurosci 18:9662-9672.
37. Frade JM, Bovolenta P, Rodriguez-Tebar A. 1999. Neurotrophins and other growth factors in the generation of retinal neurons. Microsc Res Tech 45:243-251.
38. Frankfort BJ, Mardon G. 2002. R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129:1295-1306.
39. Freund C, Horsford DJ, McInnes RR. 1996. Transcription factor genes and the developing eye: a genetic perspective. Hum Mol Genet 5:1471-1488.
40. Fuhrmann S, Heller S, Rohrer H, Hofmann HD. 1998. A transient role for ciliary neurotrophic factor in chick photoreceptor development. J Neurobiol 37:672-683.
41. Fuhrmann S, Chow L, Reh TA. 2000. Molecular control of cell diversification in the vertebrate retina. Results Probl Cell Differ 31:69-91.
42. Galli-Resta L. 2001. Assembling the vertebrate retina: global patterning from short-range cellular interactions. Neuroreport 12:A103-A106.
43. Gehring WJ, Ikeo K. 1999. Pax 6: mastering eye morphogenesis and eye evolution. Trends Genet 15:371-377.
44. Goto T, Holding C, Daniels R, Salpekar A, Monk M. 2001. Gene expression studies on human primordial germ cells and preimplantation embryos. Ital J Anat Embryol 106:119-127.
45. Goumans MJ, Mummery C. 2000. Functional analysis of the TGFbeta receptor/ Smad pathway through gene ablation in mice. Int J Dev Biol 44:253-265.
46. Hallbook F, Backstrom A, Kullander K, Ebendal T, Carri NG. 1996. Expression of neurotrophins and trk receptors in the avian retina. J Comp Neurol 364:664-676.
47. Harris WA. 1997. Cellular diversification in the vertebrate retina. Curr Opin Genet Dev 7:651-658.
48. Harrison CA, Wiater E, Gray PC, Greenwald J, Choe S, Vale W. 2004. Modulation of activin and BMP signaling. Mol Cell Endocrinol 225:19-24.
49. Hatakeyama J, Kageyama R. 2004. Retinal cell fate determination and bHLH factors. Semin Cell Dev Biol 15:83-89.
50. Hausman RE, Rao AS, Ren Y, Sagar GD, Shah BH. 1993. Retina cognin, cell signaling, and neuronal differentiation in the developing retina. Dev Dyn 196:263-266.
51. Henrique D, Hirsinger E, Adam J, Le Roux I, Pourquie O, Ish-Horowicz D, Lewis J. 1997. Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Curr Biol 7:661-770.
52. Hicks D. 1998. Putative functions of fibroblast growth factors in retinal development, maturation and survival. Semin Cell Dev Biol 9:263-269.
53. Hicks D, Courtois Y. 1992. Fibroblast growth factor stimulates photoreceptor differentiation in vitro. J Neurosci 12: 2022-2033.
54. Holt CE, Bertsch TW, Ellis HM, Harris WA. 1988. Cellular determination in the Xenopus retina is independent of lineage and birth date. Neuron 1:15-26.
55. Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, Enver T. 1997. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev 11:774-785.
56. Huang H, Adler R. 2005. Cone- and rod-specific transcriptional regulators identified by single cell cDNA suppression subtractive hybridization. ARVO Abstract.
57. Huang S, Moody SA. 1993. The retinal fate of Xenopus cleavage stage progenitors is dependent upon blastomere position and competence: studies of normal and regulated clones. J Neurosci 13:3193-3210.
58. Hunter DD, Zhang M, Ferguson JW, Koch M, Brunken WJ. 2004. The extracellular matrix component WIF-1 is expressed during, and can modulate, retinal development. Mol Cell Neurosci 27:477-488.
59. Hyatt GA, Schmitt EA, Fadool JM, Dowling JE. 1996. Retinoic acid alters photoreceptor development in vivo. Proc Natl Acad Sci U S A 93:13298-13303.
60. Ip NY, Yancopoulos GD. 1996. The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu Rev Neurosci 19:491-515.
61. Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI. 2003. Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. Dev Neurosci 25:162-172.
62. Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A. 2000. Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. J Neurosci 20:7149-7157.
63. Jean D, Ewan K, Gruss P. 1998. Molecular regulators involved in vertebrate eye development. Mech Dev 76:3-18.
64. Johnson PT, Williams RR, Reese BE. 2001. Developmental patterns of protein expression in photoreceptors implicate distinct environmental versus cell-intrinsic mechanisms. Vis Neurosci 18:157-168.
65. Kelley MW, Turner JK, Reh TA. 1994. Retinoic acid promotes differentiation of photoreceptors in vitro. Development 120: 2091-2102.
66. Kelley MW, Turner JK, Reh TA. 1995. Ligands of steroid/thyroid receptors induce cone photoreceptors in vertebrate retina. Development 121:3777-3785.
67. Kelley MW, Williams RC, Turner JK, Creech-Kraft JM, Reh TA. 1999. Retinoic acid promotes rod photoreceptor differentiation in rat retina in vivo. Neuroreport 10:2389-2394.
68. Kirsch M, Fuhrmann S, Wiese A, Hofmann HD. 1996. CNTF exerts opposite effects on in vitro development of rat and chick photoreceptors. Neuroreport 7:697-700.
69. Kirsch M, Schulz-Key S, Wiese A, Fuhrmann S, Hofmann H. 1998. Ciliary neurotrophic factor blocks rod photoreceptor differentiation from postmitotic precursor cells in vitro. Cell Tissue Res 291: 207-216.
70. Layer PG, Rothermel A, Willbold E. 1998. Inductive effects of the retinal pigmented epithelium (RPE) on histogenesis of the avian retina as revealed by retinospheroid technology. Semin Cell Dev Biol 9:257-262.
71. Layer PG, Rothermel A, Willbold E. 2001. From stem cells towards neural layers: a lesson from re-aggregated embryonic retinal cells. Neuroreport 12:A39-A46.
72. Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A. 1996. Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci 19:514-520.
73. Levine EM, Roelink H, Turner J, Reh TA. 1997. Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. J Neurosci 17:6277-6288.
74. Levine EM, Fuhrmann S, Reh TA. 2000. Soluble factors and the development of rod photoreceptors. Cell Mol Life Sci 57: 224-234.
75. Linser PJ, Moscona AA. 1984. The influence of neuronal-glial interactions on glia-specific gene expression in embryonic retina. Adv Exp Med Biol 181:185-202.
76. Livesey FJ. 2003. Strategies for microarray analysis of limiting amounts of RNA. Brief Funct Genomic Proteomic 2:31-36.
77. Livesey FJ, Cepko CL. 2001. Vertebrate neural cell-fate determination: lessons from the retina. Nat Rev Neurosci 2:109-118.
78. Lupo G, Andreazzoli M, Gestri G, Liu Y, He RQ, Barsacchi G. 2000. Homeobox genes in the genetic control of eye development. Int J Dev Biol 44:627-636.
79. Macdonald R, Barth KA, Xu Q, Holder N, Mikkola I, Wilson SW. 1995. Midline signalling is required for Pax gene regulation and patterning of the eyes. Development 121:3267-3278.
80. Madreperla SA, Adler R. 1989. Opposing microtubule- and actin-dependent forces in the development and maintenance of structural polarity in retinal photoreceptors. Dev Biol 131:149-160.
81. Malicki J. 2004. Cell fate decisions and patterning in the vertebrate retina: the importance of timing, asymmetry, polarity and waves. Curr Opin Neurobiol 14: 15-21.
82. Maric D, Barker JL. 2004. Neural stem cells redefined: a FACS perspective. Mol Neurobiol 30:49-76.
83. Marquardt T, Gruss P. 2002. Generating neuronal diversity in the retina: one for nearly all. Trends Neurosci 25:32-38.
84. Marquardt T, Ashery-Padan R, Andrejewski N, Scardigli R, Guillemot F, Gruss P. 2001. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105:43-55.
85. Martinez-Morales JR, Rodrigo I, Bovolenta P. 2004. Eye development: a view from the retina pigmented epithelium. Bioessays 26:766-777.
86. Martinez-Morales JR, Del Bene F, Nica G, Hammerschmidt M, Bovolenta P, Wittbrodt J. 2005. Differentiation of the vertebrate retina Is coordinated by an FGF signaling center. Dev Cell 8:565-574.
87. Mathers PH, Jamrich M. 2000. Regulation of eye formation by the Rx and Pax6 homeobox genes. Cell Mol Life Sci 57: 186-194.
88. McLoon SC, Barnes RB. 1989. Early differentiation of retinal ganglion cells: an axonal protein expressed by premigratory and migrating retinal ganglion cells. J Neurosci 9:1424-1432.
89. Mears AJ, Kondo M, Swain PK, Takada Y, Bush RA, Saunders TL, Sieving PA, Swaroop A. 2001. Nrl is required for rod photoreceptor development. Nat Genet 29:447-452.
90. Merrill JE, Benveniste EN. 1996. Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 19: 331-338.
91. Mey J, Thanos S. 2000. Development of the visual system of the chick. I. Cell differentiation and histogenesis. Brain Res Brain Res Rev 32:343-379.
92. Mollereau B, Domingos PM. 2005. Photoreceptor differentiation in Drosophila: from immature neurons to functional photoreceptors. Dev Dyn 232:585-592.
93. Moscona AA, Moscona M, Degenstein L. 1988. Embryonic cell recognition: uncoupling tissue-specific affinities from cell-type specificities. Cell Differ Dev 25:185-196.
94. Mu X, Klein WH. 2004. A gene regulatory hierarchy for retinal ganglion cell specification and differentiation. Semin Cell Dev Biol 15:115-123.
95. Murali D, Yoshikawa S, Corrigan RR, Plas DJ, Crair MC, Oliver G, Lyons KM, Mishina Y, Furuta Y. 2005. Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development 132: 913-923.
96. Murphy M, Dutton R, Koblar S, Cheema S, Bartlett P. 1997. Cytokines which signal through the LIF receptor and their actions in the nervous system. Prog Neurobiol 52:355-378.
97. Nasrallah I, Golden JA. 2001. Brain, eye, and face defects as a result of ectopic localization of Sonic hedgehog protein in the developing rostral neural tube. Teratology 64:107-113.
98. Neophytou C, Vernallis AB, Smith A, Raff MC. 1997. Muller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development. Development 124:2345-2354.
99. Ogilvie JM, Speck JD, Lett JM. 2000. Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture. Exp Neurol 161: 676-685.
100. Oliver G, Gruss P. 1997. Current views on eye development. Trends Neurosci 20: 415-421.
101. Paldi A. 2003. Stochastic gene expression during cell differentiation: order from disorder? Cell Mol Life Sci 60:1775-1778.
102. Patterson PH. 1994. Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology [comment]. Proc Natl Acad Sci U S A 91:7833-7835.
103. Perron M, Harris WA. 2000a. Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors. Cell Mol Life Sci 57:215-223.
104. Perron M, Harris WA. 2000b. Retinal stem cells in vertebrates. Bioessays 22:685-688.
105. Phillips DJ. 2000. Regulation of activin's access to the cell: why is mother nature such a control freak? Bioessays 22:689-696.
106. Politi LE, Rotstein NP, Carri NG. 2001. Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid. Invest Ophthalmol Vis Sci 42:3008-3015.
107. Prada FA, Quesada A, Dorado ME, Chmielewski C, Prada C. 1998. Glutamine synthetase (GS) activity and spatial and temporal patterns of GS expression in the developing chick retina: relationship with synaptogenesis in the outer plexiform layer. Glia 22:221-236.
108. Rajan P, Panchision DM, Newell LF, McKay RD. 2003. BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells. J Cell Biol 161:911-921.
109. Rapaport DH, Rakic P, LaVail MM. 1996. Spatiotemporal gradients of cell genesis in the primate retina. Perspect Dev Neurobiol 3:147-159.
110. Rapaport DH, Wong LL, Wood ED, Yasumura D, LaVail MM. 2004. Timing and topography of cell genesis in the rat retina. J Comp Neurol 474:304-324.
111. Reh TA, Levine EM. 1998. Multipotential stem cells and progenitors in the vertebrate retina. J Neurobiol 36:206-220.
112. Repka AM, Adler R. 1992. Accurate determination of the time of cell birth using a sequential labeling technique with [3H]-thymidine and bromodeoxyuridine ("window labeling"). J Histochem Cytochem 40:947-953.
113. Rosenstein JM, Krum JM. 2004. New roles for VEGF in nervous tissue-beyond blood vessels. Exp Neurol 187:246-253.
114. Rotstein NP, Politi LE, Aveldano MI. 1998. Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture. Invest Ophthalmol Vis Sci 39: 2750-2758.
115. Saha MS, Grainger RM. 1993. Early opsin expression in Xenopus embryos precedes photoreceptor differentiation. Brain Res Mol Brain Res 17:307-318.
116. Schedl A, Ross A, Lee M, Engelkamp D, Rashbass P, van Heyningen V, Hastie ND. 1996. Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell 86:71-82.
117. Schoen TJ, Chader J. 1997. Insulin-like growth factors and their blinding proteins in the developing eye. Prog Retin Eye Res 16:479-507.
118. Schulz-Key S, Hofmann HD, Beisenherz-Huss C, Barbisch C, Kirsch M. 2002. Ciliary neurotrophic factor as a transient negative regulator of rod development in rat retina. Invest Ophthalmol Vis Sci 43: 3099-3108.
119. Schwarz M, Cecconi F, Bernier G, Andrejewski N, Kammandel B, Wagner M, Gruss P. 2000. Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development 127:4325-4334.
120. Seaberg RM, van der Kooy D. 2002. Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neurosci 22:1784-1793.
121. Sebald W, Nickel J, Zhang JL, Mueller TD. 2004. Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction. Biol Chem 385:697-710.
122. Silver SJ, Rebay I. 2005. Signaling circuitries in development: insights from the retinal determination gene network. Development 132:3-13.
123. Smith L, Greenfield A. 2003. DNA microarrays and development. Hum Mol Genet 12 Spec No 1:R1-R8.
124. Snider WD. 1994. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77:627-638.
125. Soderpalm AK, Fox DA, Karlsson JO, van Veen T. 2000. Retinoic acid produces rod photoreceptor selective apoptosis in developing mammalian retina. Invest Ophthalmol Vis Sci 41:937-947.
126. Stenkamp DL, Gregory JK, Adler R. 1993. Retinoid effects in purified cultures of chick embryo retina neurons and photoreceptors. Invest Ophthalmol Vis Sci 34: 2425-2436.
127. Stenkamp DL, Barthel LK, Raymond PA. 1997. Spatiotemporal coordination of rod and cone photoreceptor differentiation in goldfish retina. J Comp Neurol 382:272-284.
128. Storkebaum E, Lambrechts D, Carmeliet P. 2004. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26:943-954.
129. Tolkovsky A. 1997. Neurotrophic factors in action - new dogs and new tricks. Trends Neurosci 20:1-3.
130. Toy J, Norton JS, Jibodh SR, Adler R. 2002. Effects of homeobox genes on the differentiation of photoreceptor and non-photoreceptor neurons. Invest Ophthalmol Vis Sci 43:3522-3529.
131. Tropepe V, Coles BL, Chiasson BJ, Horsford DJ, Elia AJ, McInnes RR, van der Kooy D. 2000. Retinal stem cells in the adult mammalian eye. Science 287:2032-2036.
132. Velde CV, Cleveland DW. 2005. VEGF: multitasking in ALS. Nat Neurosci 8:5-7.
133. Vergara C, Ramirez B. 2004. CNTF, a pleiotropic cytokine: emphasis on its myotrophic role. Brain Res Brain Res Rev 47:161-173.
134. Vetter ML, Brown NL. 2001. The role of basic helix-loop-helix genes in vertebrate retinogenesis. Semin Cell Dev Biol 12: 491-198.
135. Wahlin KJ, Lim L, Grice EA, Campochiaro PA, Zack DJ, Adler R. 2004. A method for analysis of gene expression in isolated mouse photoreceptor and Muller cells. Mol Vis 10:366-375.
136. Waid DK, McLoon SC. 1995. Immediate differentiation of ganglion cells following mitosis in the developing retina. Neuron 14:117-124.
137. Waite KA, Eng C. 2003. From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family. Nat Rev Genet 4:763-773.
138. Wallace VA, Jensen AM. 1999. IBMX, taurine and 9-cis retinoic acid all act to accelerate rhodopsin expression in postmitotic cells. Exp Eye Res 69:617-627.
139. Wernet MF, Desplan C. 2004. Building a retinal mosaic: cell-fate decision in the fly eye. Trends Cell Biol 14:576-584.
140. Wetts R, Fraser SE. 1988. Multipotent precursors can give rise to all major cell types of the frog retina. Science 239:1142-1145.
141. Xie HQ, Adler R. 2000. Green cone opsin and rhodopsin regulation by CNTF and staurosporine in cultured chick photoreceptors. Invest Ophthalmol Vis Sci 41: 4317-4323.
142. Yanagi Y, Takezawa S, Kato S. 2002. Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development. Invest Ophthalmol Vis Sci 43:3489-3494.
143. Yang XJ. 2004. Roles of cell-extrinsic growth factors in vertebrate eye pattern formation and retinogenesis. Semin Cell Dev Biol 15:91-103.
144. Young TL, Cepko CL. 2004. A role for ligand-gated ion channels in rod photoreceptor development. Neuron 41:867-879.
145. Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC. 1996. Nerve growth factor and the neurotrophic factor hypothesis. Brain Dev 18:362-368.
146. Zareparsi S, Hero A, Zack DJ, Williams RW, Swaroop A. 2004. Seeing the unseen: microarray-based gene expression profiling in vision. Invest Ophthalmol Vis Sci 45:2457-2462.
147. Zhang XM, Yang XJ. 2001. Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev Biol 233:271-290.
148. Zhang SS, Fu XY, Barnstable CJ. 2002a. Molecular aspects of vertebrate retinal development. Mol Neurobiol 26:137-152.
149. Zhang SS, Fu XY, Barnstable CJ. 2002b. Tissue culture studies of retinal development. Methods 28:439-147.
150. Ziman MR, Rodger J, Chen P, Papadimitriou JM, Dunlop SA, Beazley LD. 2001. Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration. Histol Histopathol 16:239-249.