Pharmacokinetics and tissue fluid distribution of cephalexin in the horse after oral and i.v. administration

Journal of Veterinary Pharmacology and Therapeutics

Volumn 28, Issue 5, 2005, Pages 425-431

  Davis, Jennifer L ^a   Salmon, J H ^a   Papich, M G ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFALEXIN;

ANIMAL EXPERIMENT; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; INTERSTITIAL FLUID; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; TISSUE WATER; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; CEPHALEXIN; CROSS-OVER STUDIES; FEMALE; HORSES; INJECTIONS, INTRAVENOUS; MALE; TISSUE DISTRIBUTION;

ANIMALIA; BACTERIA (MICROORGANISMS); EQUIDAE; EQUUS CABALLUS; POSIBACTERIA;

EID: 27444437154     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2005.00683.x     Document Type: Article

References (34)

1. Ashby, J., Piddock, L.J.V. & Wise, R. (1985) An investigation of the hydrophobicity of the quinolones. Journal of Antimicrobial Chemotherapy, 16, 805-808.
2. Asuquo, A.E. & Piddock, L.J.V. (1993) Accumulation and killing kinetics of fifteen quinolones for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy. 31, 865-880.
3. Berlioz, F., Lepere-Prevot, B., Julien, S., Tsocas, A., Carbon, C., Roze, C. & Farinotti, R. (2000) Chronic nifedipine dosing enhances cephalexin bioavailability and intestinal absorption in conscious rats. Drug Metabolism and Disposition, 28, 1267-1269.
4. Bidgood, T. & Papich, M.G. (2002) Plasma pharmacokinetics and tissue fluid concentrations of meropenem after intravenous and subcutaneous administration in dogs. American Journal of Veterinary Research, 63, 1622-1628.
5. Bidgood, T. & Papich, M.G. (2003) Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs. American Journal of Veterinary Research, 64, 1040-1046.
6. Brown, K.N. & Percival, A. (1978) Penetration of antimicrobials into tissue culture cells and leucocytes. Scandinavian Journal of Infectious Diseases Supplementum, 14, 251-260.
7. Brown, S.A., Papich, M.G. & Prescott, J.A. (2004) Pharmacologic and Microbiologic Characteristics of Cephalosporins. Cefpodoxime Monograph, Pfizer Animal Health.
8. Cadorniga, R., Barrios, S., Segura, J. & Roberts, D.J. (1979) Penetration of antibiotic into interstitial tissue fluid following parenteral administration of lysine cephalexin. Arzneimittel-Forschung, 29, 1547-1549.
9. Carrillo, N.A., Giguere, S., Gronwall, R.R., Brown, M.P., Merritt, K.A. & O'Kelley, J.J. (2005) Disposition of orally administered cefpodoxime proxetil in foals and adult horses and minimum inhibitory concentration of the drug against common bacterial pathogens. American Journal of Veterinary Research, 66, 30-35.
10. Clarke, C.R., Short, C.R., Bourne, D.W. & Usenik, E.A. (1989) Subcutaneously implanted tissue chambers - a pharmacokinetic study. Journal of Veterinary Pharmacology and Therapeutics, 12, 312-321.
11. Duffee, N.B., Christensen, J.M. & Craig, A.M. (1989) The pharmacokinetics of cefadroxil in the foal. Journal of Veterinary Pharmacology and Therapeutics, 12, 322-326.
12. Gager, W.E., Elsas, F.J. & Smith, J.L. (1969) Ocular penetration of cephalexin in the rabbit. British Journal of Ophthalmology, 53, 403-406.
13. Gower, P.E. & Dash, C.H. (1969) Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic. British Journal of Pharmacology, 37, 738-747.
14. Griffith, R.S. (1983) The pharmacology of cephalexin. Postgraduate Medical Journal, 59 (Suppl. 5), 16-27.
15. Griffith, R.S. & Black, H.R. (1970) Cephalexin. Medical Clinics of North America, 54, 1229-1244.
16. Henry, M.M., Morris, D.D., Lakritz, J. & Aucoin, D. (1992) Pharmacokinetics of cephradine in neonatal foals after single oral dosing. Equine Veterinary Journal, 24, 242-243.
17. Jalava, S., Saarimaa, H. & Elfving, R. (1977) Cephalexin levels in serum, synovial fluid and joint tissues after oral administration. Scandinavian Journal of Rheumatology, 6, 250-252.
18. Lees, P., May, S.A., Hooke, R.E. & Silley, P. (1990) Cephalexin in ponies: a preliminary investigation. Veterinary Record, 126, 635-637.
19. NCCLS (2002) Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals: Approved Standards, 2nd edn. pp. M31-A2.
20. Nightingale, C.H. (1986) Penetration and concentration of cefadroxil in sputum, lung and pleural fluid. Drugs, 32 (Suppl. 3), 17-20.
21. Papich, M.G. (1984) Clinical pharmacology of cephalosporin antibiotics. Journal of the American Veterinary Medical Association, 184, 344-347.
22. Papich, M.G. (1987) The beta-lactam antibiotics: clinical pharmacology and recent developments. The Compendium on Continuing Education for the Practicing Veterinarian, 9, 68-76.
23. Papich, M.G. (1988) Therapy of gram-positive bacterial infections. The Veterinary Clinics of North America Small Animal Practice, 18, 1267-1285.
24. Purcell, W.P., Bass, G.E. & Clayton, J.M. (1973) Strategy of Drug Design. A Molecular Guide to Biological Activity: App. I. Experimental Determination of Partition Coefficients, pp. 545-549. Wiley, NY, USA.
25. Ryan, D.M. (1985) Influence of surface area/volume ratio on the kinetics of antibiotics in different tissues and tissue fluids. Scandinavian Journal of Infectious Disease Supplementum, 44 (Suppl.), 24-33.
26. Ryan, D.M. & Cars, O. (1983) A problem in the interpretation of β-lactam levels in tissues. Journal of Antimicrobial Chemotherapy, 12, 281-284.
27. Schott, H.L. (2004) Urinary tract infections. In Equine Internal Medicine. Eds Reed, S.M., Bayly, W.M. & Sellon, D.C. pp. 1253-1258. WB Saunders Co, St Louis, MO, USA.
28. Short, C.R., Beadle, R.E., Aranas, T., Pawlusiow, J. & Clarke, C.R. (1987) Distribution of cephapirin into a tissue chamber implanted subcutaneously in horses. Journal of Veterinary Pharmacology and Therapeutics, 10, 241-247.
29. Turnidge, J.D. (1998) The pharmacodynamics of β-lactams. Clinical Infectious Diseases, 27, 10-22.
30. USP-NF (2004) United States Pharmacopeia - National Formulary. General Chapter on Chromatography. pp. 2272-2283. USP, Rockville, MD, USA.
31. Villa, R., Belloli, C., Cagnardi, P., Sonzogni, O., Bacchetta, S. & Carli, S. (2002) Pharmacokinetics of cephalexin in the horse after intravenous and intramuscular administration of two formulations. Veterinary Journal, 164, 74-76.
32. Wilson, W.D., Baggot, J.D., Adamson, P.J., Hirsh, D.C. & Hietala, S.K. (1985) Cefadroxil in the horse: pharmacokinetics and in vitro antibacterial activity. Journal of Veterinary Pharmacology and Therapeutics, 8, 246-253.
33. Wise, R. (1986) The clinical relevance of protein binding and tissue concentrations in antimicrobial therapy. Clinical Pharmacokinetics, 11, 470-482.
34. Yamaoka, K., Nakagawa, T. & Uno, T. (1978) Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics, 6, 165-175.