Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: Therapeutic effects of nourishing "Yin"-removing "Fire" Chinese Herb Mixture

Reproductive Biology and Endocrinology

Volumn 3, Issue , 2005, Pages

  Tian, Zhanzhuang ^a   Zhao, Hong ^a   Sun, Yan ^a   Cai, Depei ^b   Chen, Boying ^a  

^a FUDAN UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; DANAZOL; GONADORELIN; HERBACEOUS AGENT; NOURISHING YIN REMOVING FIRE; NOURISHING YIN-REMOVING FIRE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG MECHANISM; DRUG RESPONSE; ESTROGEN BLOOD LEVEL; ESTRUS CYCLE; FEMALE; GENE EXPRESSION; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRECOCIOUS PUBERTY; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL MATURATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; DANAZOL; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUGS, CHINESE HERBAL; ESTROUS CYCLE; FEMALE; GONADOTROPIN-RELEASING HORMONE; PUBERTY, PRECOCIOUS; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL MATURATION;

EID: 27344454690     PISSN: 14777827     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-3-38     Document Type: Article

References (14)

1. Ge QS: Precocious puberty. J Reprod Med 2000, 9:377-380.
2. Samuel Yen SC: Reproductive Endocrinology: physiology, pathophysiology and clinical management. 4th edition. W.B. Saunders Company; 2001:388-412.
3. Morishito H, Takemoto M, Kondo H, Higuchi K, Aono T: Induction of true precocious puberty by neonatal treatment with danazol in female rats. Neurosci Lett 1993, 157:33-36.
4. Heger S, Sippell WG, Partsch CJ: Gonadotropin-releasing hormone analogue treatment for precocious puberty. Twenty years of experience. Endocr Dev 2005, 8:94-125.
5. Cai D, Zhang W: Regulative actions of the Chinese drugs for tonifying the kidney on gene expression of the hypothalamic GnRH, pituitary FSH, LH and osteoblastic BGP. J Tradit Chin Med 2005, 25:58-61.
6. Bao XM, Shu SY: Stereostic Brain Atlas. Beijing People's Health Press; 1991:22-30.
7. Tian ZZ, Zhao H, Chen BY: Expression of GnRH and GnRH receptor mRNA in female rats with danazol-induced precocious puberty. Chin J Endocrinol Metab 2003, 19:399-401.
8. Witkin J: Morphology of luteinizing hormone-releasing hormone neurons as a function of age and hormonal condition in the male rat. Neuroendocrinology 1989, 49:344-348.
9. Terasawa EI, Fernandez DL: Neurobiological mechanism of the onset of puberty in primates. Endocrin Rev 2001, 22:111-150.
10. Clive MD, Jonathan R, Timothy WJ, Robert PM: Prepubertal increase in gonadotropin-releasing hormone mRNA, gonadotropin-releasing hormone precursor, and subsequent maturation of precursor processing in rats. J Clin Invest 1992, 90:2496-2501.
11. Pinyerd B, Zipf WB: Puberty-timing is everything! J Pediatr Nurs 2005, 20:75-82.
12. Zhao H, Tian ZZ, Chen BY: Progress on GnRH cells model (review). Prog Physiol 2004, 35:185-187. (in Chinese)
13. Pinilla L, Lopez F, Gonzalez D, Fernandez C, Criado JES, Aguilar E: Luteinizing-hormone-mediated precocious puberty induced in female rats by a prepubertal pituitary graft. Neuroendocrinology 1989, 50:495-499.
14. Tian ZZ, Zhao H, Chen BY: Decreased hypothalamic aromatase in female rats of precocious puberty. Neurosci Lett 2004, 366:92-96.